| Project/Area Number |
23790399
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Human pathology
|
|---|
| Research Institution | Kobe University |
|---|
Principal Investigator |
HARA Shigeo 神戸大学, 医学部附属病院, 講師 (10590648)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 甲状腺 / 濾胞上皮 / 小胞輸送 / SNX2 / 癌と病理学 |
|---|
| Research Abstract |
In normal thyroid tissue, SNX2 was expressed in columnar thyroid follicular cells that reflect active state of thyrocytes. Most of the flattened thyrocytes, which indicates cells in inactive state, did not show apparent SNX2 immunostaining. Sortilin, which is expressed by active thyrocytes, also exhibited similar distribution in follicular cells. Expression of SNX2 in thyrocytes is particularly marked in most hyperstimulated thyroid disorders, including Graves disease and functioning nodules. In FRTL-5 cells, cells expressed increased amount of SNX2 and sortilin protein when cells were stimulated with thyroid stimulating hormone. Morphometric analysis revealed increased cell size that corresponds to histological findings. Regarding thyroid cancer, SNX2 was diffusely positive for papillary carcinoma. In sumary, increased SNX2 expression indicates active thyrocytes, and may reflect increased level of endosomal trafficking in thyroid cancer cells.
|
