| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
We evaluated immunohistochemical expression of oxidative stress markers (COX2、iNOS、8-OHdG) in ovarian clear cell adenocarcinomas. With respect to clear cell-dominant clear cell adenocarcinomas, the immunopositivity for COX2, iNOS and 8-OHdG were 62%、36%、55%, respectively. With respect to oxyphilic cell-dominant clear cell adenocarcinomas, the immunopositivity for COX2, iNOS and 8-OHdG were 77%、67%、77%, respectively. With respect to endometrioid adenocarcinomas, the immunopositivity for COX2, iNOS and 8-OHdG were 75%、65%、0%, respectively. However, the immunopositivity for 8-OHdG in clear cells of endometrioid adenocarcinomas were 66%. It is suggested that ovarian clear cell adenocarcinomas are affected by oxidative stress. 8-OHdG immunopositivity appeared to correlated with cytoplasmic clear cell change of carcinoma cells
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