| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Research Abstract |
Genomic instability (GIN) is generally considered to be a central aspect of any carcinogenic process and is correlated with malignant potential. We have examined significance of GIN in esophageal carcinogenesis. We use a protein of 53BP1 localized at the sites of DNA double strand breaks and forms discrete nuclear foci to detect GIN. In this study, grade of esophageal dysplasia increases, expression of 53BP1 was increased. This suggested a constitutive activation of DNA damage response in esophageal tumors and increased GIN with progression of cancer. The detection of 53BP1 expression by immunofluorescence can be a useful histological marker to estimate the malignant potential of human esophageal intraepithelial neoplasm.
|
