Hypoxia in atherosclerotic plaque and thrombus formation

• Project/Area Number: 23790410
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Human pathology
• Research Institution: University of Miyazaki
• Principal Investigator: YAMASHITA Atsushi 宮崎大学, 医学部, 助教 (90372797)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 動脈硬化症 / 低酸素 / 血栓 / アテローム血栓症 / 凝固因子

Research Abstract

Nuclear translocation of hypoxia inducible factor-1a increased in human thrombotic coronary plaques compared with that in non-thrombotic plaques. Hypoxic area in rabbit atherosclerotic plaquescorrelated with balloon catheter induced thrombus size. The results suggest that hypoxia in atherosclerotic plaque contribute to vascular thrombogenicity.

Research Products

• [Journal Article] Plasma factor Xa inhibition can predict antithrombotic effects of oral direct factor Xa inhibitors in rabbit atherothrombosis models. (2012)
  • Author(s): Funatsu T, Yamashita A, Kaku S, et al (5)
  • Journal Title: Thromb Haemost. Volume: 108 Issue: 11 Pages: 896-902
  • DOI: 10.1160/th12-04-0267
  • Peer Reviewed
• [Journal Article] Paucity of CD34-positive cells and increased expression of high-mobility group box 1 in coronary thrombus with type 2 diabetes mellitus. (2012)
  • Author(s): Yamashita A, Nishihira K, Matsuura Y, Ito T, Kawahara K, Hatakeyama K, Hashiguchi T, Maruyama I, Yagi H, Matsumoto M, Fujimura Y, Kitamura K, Shibata Y, Asada Y.
  • Journal Title: Atherosclerosis. Volume: 224 Issue: 2 Pages: 511-514
  • DOI: 10.1016/j.atherosclerosis.2012.07.027
  • Peer Reviewed
• [Journal Article] Loss of cellular viability in areas of ground-glass opacity on computed tomography images immediately after pulmonary radiofrequency ablation in rabbits. (2012)
  • Author(s): Kuroki M
  • Journal Title: Jpn J Radiol. Volume: 30 Issue: 4 Pages: 323-30
  • DOI: 10.1007/s11604-012-0054-y
  • Peer Reviewed
• [Journal Article] Human c-reactive protein enhances thrombus formation after neointimal balloon injury in transgenic rabbits (2011)
  • Author(s): Matsuda S, et al
  • Journal Title: J Thromb Haemost Volume: 9 Issue: 1 Pages: 201-208
  • DOI: 10.1111/j.1538-7836.2010.04086.x
  • Peer Reviewed
• [Journal Article] A rabbit model of thrombosis on atherosclerotic lesions. (2011)
  • Author(s): Yamashita A, Asada Y.
  • Journal Title: J Biomed Biotechnol. Volume: 2011 Issue: 1 Pages: 1-15
  • DOI: 10.1155/2011/424929
  • Peer Reviewed
• [Journal Article] Relative contributions of 5-hydroxytryptamine (5-HT) receptor subtypes in 5-HT-induced vasoconstriction of the distended human saphenous vein as a coronary artery bypass graft (2011)
  • Author(s): Nakamura E, Tanaka N, Kuwabara M, Yamashita A, et al.(10)
  • Journal Title: Biol Pharm Bull Volume: 34 Pages: 82-6
  • NAID: 130000402267
  • Peer Reviewed
• [Journal Article] Quantitative analysis of vessels with smooth muscle layer in astrocytictumors: correlation with histological grade and prognostic significance (2011)
  • Author(s): Sato S, Sato Y, Hatakeyama K, Marutsuka K, Yamashita A, et al.(7)
  • Journal Title: Histol Histopathol Volume: 26 Pages: 497-504
  • Peer Reviewed
• [Journal Article] MR signal change in venous thrombus relates organizing process and thrombolytic response in rabbit (2011)
  • Author(s): Kuroiwa Y, Yamashita A, Miyati T, et al.(11)
  • Journal Title: Magn Reson Imaging Volume: 29 Issue: 7 Pages: 975-8
  • DOI: 10.1016/j.mri.2011.04.015
  • Peer Reviewed
• [Journal Article] Cardiac Rupture in Acute Myocardial Infarction: Post-mortem MR Imaging (2011)
  • Author(s): Kuroiwa Y, Yamashita A, Nishihira K, Shibata Y, Matsuura Y, Maeda M, Asada Y.
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 10 Issue: 4 Pages: 255-258
  • DOI: 10.2463/mrms.10.255
  • NAID: 10030284665
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed
• [Presentation] 動脈血管壁への18F -フルオロデオキシグルコース集積は血栓形成能を反映する (2012)
  • Author(s): 山下 篤, 他
  • Organizer: 第34回日本血栓止血学会学術集会
  • Place of Presentation: 東京
• [Presentation] 症候性血栓と無症候性血栓を伴う冠動脈病変の比較 (2012)
  • Author(s): 松田俊太郎, 山下 篤, 他
  • Organizer: 第34回日本血栓止血学会学術集会
  • Place of Presentation: 東京
• [Presentation] What determine arterial thrombus size on disrupted plaques? (2012)
  • Author(s): Yamashita A, Asada Y.
  • Organizer: 1^st Japan-China joint Rabbit Bioscience Forum
  • Place of Presentation: Miyazaki.
• [Presentation] 血栓成分の違いがMR所見の不均一性に関連する (2012)
  • Author(s): 黒岩 靖淳、山下 篤、他
  • Organizer: 第40回日本磁気共鳴医学大会
  • Place of Presentation: 京都
• [Presentation] 18F -FDG uptake reflects thrombus formation and tissue factor expression via nuclear factor-κB in rabbit atherosclerotic lesions (2012)
  • Author(s): Ya ma shi t a A, Zhao Y, Zhao S, et al
  • Organizer: American Heart Association Scientific Sessions 2012
  • Place of Presentation: Los Angels, USA.
• [Presentation] Interactive contribution of HIF-1a and NF-kB. Ma t suura Y, Ya ma shi t a A, Iwakiri T, et al. (2012)
  • Author(s): Vascular hypoxia augments thrombogenic potential of atherosclerotic plaque
  • Organizer: American Heart Association Scientific Sessions 2012
  • Place of Presentation: Los Angels, USA.
• [Presentation] 動脈血管壁への18F-フルオロデオキシグルコース集積は血栓形成能を反映する (2012)
  • Author(s): 山下 篤
  • Organizer: 第34回日本血栓止血学会学術集会
  • Place of Presentation: 東京
• [Presentation] What determine arterial thrombus size on disrupted plaques? (2012)
  • Author(s): Yamashita A
  • Organizer: 1st Japan-China joint Rabbit Bioscience Forum
  • Place of Presentation: 宮崎市
  • Invited
• [Presentation] 血栓成分の違いがMR所見の不均一性に関連する (2012)
  • Author(s): 黒岩 靖淳
  • Organizer: 第39回日本磁気共鳴医学大会
  • Place of Presentation: 京都
• [Presentation] 18F-FDG uptake reflects thrombus formation and tissue factor expression via nuclear factor-κB in rabbit atherosclerotic lesions. (2012)
  • Author(s): Yamashita A
  • Organizer: American Heart Association Scientific Sessions 2012
  • Place of Presentation: Los Angels
• [Presentation] 10) Vascular hypoxia augments thrombogenic potential of atherosclerotic plaque: Interactive contribution of HIF-1α and NF-κB. (2012)
  • Author(s): Matsuura Y
  • Organizer: American Heart Association Scientific Sessions 2012
  • Place of Presentation: Los Angels
• [Presentation] Elevated plasma levels of factor VIII enhance thrombus formation though excess thrombin generation in rabbit jugular vein (2011)
  • Author(s): Sugita C. Yamashita A,et al
  • Organizer: XXIII Congress of International Society on Thrombosis and Haemostasis
  • Place of Presentation: Kyoto
• [Presentation] Sequential magnetic resonance signal change of venous thrombus relates to organizing processes and thrombolytic responses in rabbits (2011)
  • Author(s): Kuro i wa Y, Ya ma shi t a A, et al
  • Organizer: XXIII Congress of International Society on Thrombosis and Haemostasis
  • Place of Presentation: Kyoto
• [Presentation] Sequential magnetic resonance signal change of venous thrombus relates to organizing processes and thrombolytic responses in rabbits (2011)
  • Author(s): Ya ma shi t a A, Kuroiwa Y, Asada Y.
  • Organizer: Aso International Meeting
  • Place of Presentation: Kyoto
• [Presentation] Thrombus formation on disrupted plaques (2011)
  • Author(s): Ya ma shi t a A
  • Organizer: XXIII Congress of International Society on Thrombosis and Haemostasis
  • Place of Presentation: Kyoto
• [Presentation] Disturbed blood flow induces plaque erosion and thrombus formation (2011)
  • Author(s): Ya ma shi t a A
  • Organizer: 57th annual SCC meeting
  • Place of Presentation: Kyoto
• [Presentation] Thrombus formation on disrupted plaques (2011)
  • Author(s): Yamashita A
  • Organizer: XXIII congress of International Society on Thrombosis and Haemostasis(招待講演)
  • Place of Presentation: Kyoto
• [Book] In: Traditional and novel risk factors in atherothrombosis (2012)
  • Author(s): Ya ma shi t a A, Asada Y.
  • Publisher: Pathology and pathophysiology of atherothrombosis: Virchow's triad revisited
• [Book] Traditional and novel risk factors in atherothrombosis (2012)
  • Author(s): Yamashita A
  • Total Pages: 140
  • Publisher: Intech
• [Remarks]
  • URL: http://www.miyazaki-med.ac.jp/patho1/index.htm
• [Patent(Industrial Property Rights)] 動脈硬化の検査法 (2012)
  • Inventor(s): 浅田祐士郎、北村和雄、山下 篤、松浦祐之介
  • Industrial Property Rights Holder: 国立大学法人宮崎大学
  • Filing Date: 2012-03-31