Hypoxia in atherosclerotic plaque and thrombus formation
| Project/Area Number |
23790410
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Human pathology
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 動脈硬化症 / 低酸素 / 血栓 / アテローム血栓症 / 凝固因子 |
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| Research Abstract |
Nuclear translocation of hypoxia inducible factor-1a increased in human thrombotic coronary plaques compared with that in non-thrombotic plaques. Hypoxic area in rabbit atherosclerotic plaquescorrelated with balloon catheter induced thrombus size. The results suggest that hypoxia in atherosclerotic plaque contribute to vascular thrombogenicity.
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Report
(3 results)
Research Products
(30 results)
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[Journal Article] Paucity of CD34-positive cells and increased expression of high-mobility group box 1 in coronary thrombus with type 2 diabetes mellitus.2012
Author(s)
Yamashita A, Nishihira K, Matsuura Y, Ito T, Kawahara K, Hatakeyama K, Hashiguchi T, Maruyama I, Yagi H, Matsumoto M, Fujimura Y, Kitamura K, Shibata Y, Asada Y.
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Journal Title
Atherosclerosis.
Volume: 224
Issue: 2
Pages: 511-514
DOI
Related Report
Peer Reviewed
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