| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
Our previous studies identified important molecules involved in carcinogenesis of the lung through a comprehensive search for the downstream targets of oncogenic KRAS. The present study investigated such downstream targets by oncogenic KRAS-transduced airway epithelial cells. Results confirmed the changes of the expression levels in almost all target molecules. The expression levels of the three chemokines (CXCL4(PPBP), CCL3, CXCL2) and S100 families were highly elevated in some KRAS-mutated primary lung adenocarcinoma lesions. Protein expression analyses showed the higher expression levels of S100 families in primary lung adenocarcinoma lesions with mutated KRAS and high-proliferating activity.
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