Characteristic of the molecular pathology of the lung adenocarcinomas with mutated KRAS and high-proliferating activity.
Project/Area Number |
23790411
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Human pathology
|
Research Institution | Yokohama City University |
Principal Investigator |
WOO Tetsukan 横浜市立大学, 医学研究科, 共同研究員 (90537177)
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 肺癌 / KRAS / 増殖活性 |
Research Abstract |
Our previous studies identified important molecules involved in carcinogenesis of the lung through a comprehensive search for the downstream targets of oncogenic KRAS. The present study investigated such downstream targets by oncogenic KRAS-transduced airway epithelial cells. Results confirmed the changes of the expression levels in almost all target molecules. The expression levels of the three chemokines (CXCL4(PPBP), CCL3, CXCL2) and S100 families were highly elevated in some KRAS-mutated primary lung adenocarcinoma lesions. Protein expression analyses showed the higher expression levels of S100 families in primary lung adenocarcinoma lesions with mutated KRAS and high-proliferating activity.
|
Report
(3 results)
Research Products
(27 results)
-
-
[Journal Article] Downregulation of ALDH1A1 expression in non-small cell lung carcinomas-its clinicopathologic and biological significance2013
Author(s)
Okudela K, Woo T, Mitsui H, Suzuki T, Tajiri M, Sakuma Y, Miyagi Y, Tateishi Y, Umeda S, Masuda M, Ohashi K
-
Journal Title
Int J Clin Exp Pathol
Volume: 6(1)
Pages: 1-12
URL
Related Report
Peer Reviewed
-
-
-
[Journal Article] Expression of the potential cancer stem cell markers, CD133, CD44, ALDH1, and beta-catenin, in primary lung adenocarcinoma-their prognostic significance2012
Author(s)
Okudela K, Woo T, Mitsui H, Tajiri M, Masuda M, et al.
-
Journal Title
Pathol Int
Volume: 62
Issue: 12
Pages: 792-801
DOI
Related Report
Peer Reviewed
-
[Journal Article] Severe Obliterative Bronchitis Associated with Stevens-Johnson Syndrome2011
Author(s)
Woo T, Saito H, Yamakawa Y, Komatsu S, Onuma S, Okudela K, Nozawa A, Aihara M, Ikezawa Z, Ishigatsubo Y
-
Journal Title
Internal Medicine
Volume: 50
Issue: 22
Pages: 2823-2827
DOI
NAID
ISSN
0918-2918, 1349-7235
Related Report
Peer Reviewed
-
[Journal Article] Storomal micropapillary pattern predominant lung adenocarcinoma-a report of two cases2011
Author(s)
Ohe M, Yokose T, Sakuma Y, Osanai S, Hasegawa C, Washimi K, Nawa K, Woo T, Hamanaka R, Nakayama H, Kameda Y, Yamada K, Isobe T
-
Journal Title
Diagn Pathol
Volume: 6
Issue: 1
Pages: 92-92
DOI
Related Report
Peer Reviewed
-
[Journal Article] Insulin-like growth factor binding protein-4 gene silencing in lung adenocarcinomas2011
Author(s)
Sato H, Sakaeda M, Ishii J, Kashiwagi K, Shimoyamada H, Okudela K, Tajiri M, Ohmori T, Ogura T, Woo T, Masuda M, Hirata K, Kitamura H, Yazawa T
-
Journal Title
Pathol Int
Volume: 61(1)
Pages: 19-27
Related Report
Peer Reviewed
-
-
[Journal Article] Insulin-like growth factor binding protein-4 gene silencing in lung adenocarcinomas2011
Author(s)
Sato H, Sakaeda M, Ishii J, Kashiwagi K, Shimoyamada H, Okudela K, Tajiri M, Ohmori T, Ogura T, Woo T, Masuda M, Hirata K, Kitamura H, Yazawa T
-
Journal Title
Pathology International
Volume: 61(1)
Issue: 1
Pages: 19-27
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
[Presentation] 原発性肺癌との鑑別を要した、尾骨Adamantinoma術後17年目に肺転移した1例2011
Author(s)
禹哲漢, 中山治彦, 坪井正博, 伊藤宏之, 名和公敏, 濱中瑠利香, 山田耕三, 長谷川千花子, 横瀬智之, 亀田陽一, 益田宗孝
Organizer
第169回 日本肺癌学会 関東支部会
Place of Presentation
京王プラザ(東京都)
Related Report
-
-
-
-
[Presentation] 肺腺癌の腫瘍増大速度とEGFR/KRAS遺伝子変異の検討2011
Author(s)
禹哲漢, 斉藤春洋, 佐久間裕司, 剱持喜之, 杉浦真貴子, 大江美紀, 村上修司, 近藤哲郎, 尾下文浩, 有賀直広, 濱中瑠利香, 名和公敏, 伊藤宏之, 中山治彦, 山田耕三
Organizer
第52会日本肺癌学会総会
Place of Presentation
大阪国際会議場(大阪府)
Related Report
-
-