EMT-targeted molecular therapy for renal cell carcinoma

• Project/Area Number: 23790417
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Human pathology
• Research Institution: Keio University
• Principal Investigator: MIKAMI Shuji 慶應義塾大学, 医学部, 助教 (20338180)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 上皮-間葉転換 / 腎細胞癌 / TNF-α / 転移 / 分子標的薬 / 浸潤 / 分子標的治療 / 癌幹細胞 / 上皮ー間葉転換 / TNF

Research Abstract

TNF-α and CD44 were expressed in carcinoma cells of high-grade clear cell renal cell carcinomas (ccRCCs) and the expression levels showed positive correlation with primary tumor stage and distant metastasis. Elevated expression of TNF-α and CD44 was pr

Research Products

• [Journal Article] The prognostic significance of vasohibin-1 expression in patients with upper urinary tract urothelial carcinoma (2012)
  • Author(s): Miyazaki Y, Kosaka T, Mikami S, Kikuchi E, Tanaka N, Maeda T, Ishida M, Miyajima A, Nakagawa K, Okada Y, Sato Y, Oya M
  • Journal Title: Clin Cancer Res Volume: 18 Pages: 4145-53
  • Peer Reviewed
• [Journal Article] Prognostic role of KiSS-1 and possibility of therapeutic modality of metastin, the final peptide of the KiSS-1 gene, in urothelial carcinoma. (2012)
  • Author(s): Takeda T, Kikuchi E, Mikami S, Suzuki E, Matsumoto K, Miyajima A, Okada Y, Oya M
  • Journal Title: Mol Cancer Ther Volume: 11 Pages: 853-63
  • Peer Reviewed
• [Journal Article] Tumor cell-derived angiopoietin-like protein ANGPTL2 is a critical driver of metastasis (2012)
  • Author(s): Endo M, Nakano M, Kadomatsu T, Fukuhara S, Kuroda H, Mikami S, Hato T, Aoi J, Horiguchi H, Miyata K, Odagiri H, Masuda T, Harada M, Horio H, Hishima T, Nomori H, Ito T, Yamamoto Y, Minami T, Okada S, Takahashi T, Mochizuki N, Iwase H, Oike Y
  • Journal Title: Cancer Res Volume: 72(7) Pages: 1784-94
  • Peer Reviewed
• [Journal Article] Regulation of monocyte chemoattractant protein-1 through angiotensin II type 1 receptor in prostate cancer (2012)
  • Author(s): Shirotake S, Miyajima A, Kosaka T, Tanaka N, Kikuchi E, Mikami S, Okada Y, Oya M
  • Journal Title: Am J Pathol Volume: 180 Pages: 1008-16
  • Peer Reviewed
• [Journal Article] Prognostic significance of high nuclear grade in patients with pathologic T1a renal cell carcinoma. (2012)
  • Author(s): Suzuki K, Mizuno R, Mikami S, Tanaka N, Kanao K, Kikuchi E, Miyajima A, Nakagawa K, Oya M
  • Journal Title: Jpn J Clin Oncol Volume: 42 Pages: 831-5
  • Peer Reviewed
• [Journal Article] Multilocular cystic renal cell carcinoma with focus on clinical and pathobiological aspects. (2012)
  • Author(s): Kuroda N, Ohe C, Mikami S, Inoue K,Nagashima Y, Cohen RJ, Pan CC, Michal M, Hes O
  • Journal Title: Histol Histopathol. Volume: 27(8) Pages: 969-74
  • Peer Reviewed
• [Journal Article] Patterns of interstitial lung disease during everolimus treatment in patients with metastatic renal cell carcinoma (2012)
  • Author(s): Mizuno R, Asano K, Mikami S, Nagata H, Kaneko G, Oya M
  • Journal Title: Jpn J Clin Oncol Volume: 42 Pages: 442-6
  • Peer Reviewed
• [Journal Article] The prognostic significance of vasohibin-1 expression in patients with upper urinary tracturothelial carcinoma (2012)
  • Author(s): Miyazaki Y, Kosaka T, Mikami S, Kikuchi E, Tanaka N, Maeda T, Ishida M, Miyajima A, Nakagawa K, Okada Y, Sato Y, Oya M
  • Journal Title: Clin Cancer Res Volume: 18 Issue: 15 Pages: 4145-4153
  • DOI: 10.1158/1078-0432.ccr-12-0073
  • Peer Reviewed
• [Journal Article] Prognostic role of KiSS-1 and possibility of therapeutic modality of metastin, the final peptide of the KiSS-1 gene, in urothelial carcinoma (2012)
  • Author(s): Takeda T
  • Journal Title: Mol Cancer Ther Volume: 11 Issue: 4 Pages: 853-863
  • DOI: 10.1158/1535-7163.mct-11-0521
  • Peer Reviewed
• [Journal Article] Expression of Snail and Slug in renal cell carcinoma: E-cadherin repressor Snail is associated with cancer invasion and prognosis. (2011)
  • Author(s): Mikami S, Katsube K, Oya M, Ishida M, Kosaka T, Mizuno R, Mukai M, Okada Y
  • Journal Title: Lab Invest Volume: 91 Pages: 1443-58
  • Peer Reviewed
• [Journal Article] Clear cell adenocarcinoma arising in endometrial adenofibroma (2011)
  • Author(s): Mikami S, Kikunaga H, Kameyama K, Mukai M
  • Journal Title: Pathol Int Volume: 61(3) Pages: 167-70
  • Peer Reviewed
• [Journal Article] The Clinical Impact of the Classification of Carcinoma In Situ on Tumor Recurrence and their Clinical Course in Patients with Bladder Tumor (2011)
  • Author(s): Hayakawa N, Kikuchi E, Mikami S, Matsumoto K, Miyajima A, Oya M
  • Journal Title: Jpn. J Clin Oncol Volume: 41(3) Pages: 424-9
  • Peer Reviewed
• [Journal Article] Intra-sellar Salivary Gland-like Pleomorphic Adenoma. (2011)
  • Author(s): Takahashi S, Mikami S, Akiyama T, Kawase T
  • Journal Title: Neurosurgery Volume: 68(2) Pages: 562-5
  • Peer Reviewed
• [Presentation] 腎細胞癌の異型性と浸潤・転移 (2012)
  • Author(s): 三上修治、大家基嗣、勝部憲ー、向井万起男、岡田保典
  • Organizer: 第44回日本臨床分子形態学会総会。シンポジウム:腎がん研究の分子形態学的アプローチ
  • Place of Presentation: 高知
• [Presentation] 腎細胞癌におけるADAM17発現の意義 (2012)
  • Author(s): 三上修治 、大家基嗣、石田勝、水野隆一、向井万起男、岡田保典
  • Organizer: 第101回日本病理学会総会
  • Place of Presentation: 東京
• [Presentation] 腎細胞癌の異型性と浸潤・転移 (2012)
  • Author(s): 三上 修治
  • Organizer: 第４４回日本臨床分子形態学会総会。シンポジウム:腎がん研究の分子形態学的アプローチ
  • Place of Presentation: 高知
• [Presentation] 腎細胞癌におけるEMT誘導因子TNF-発現の意義および機能解析
  • Author(s): 三上修治 大家基嗣 石田勝 小坂威男 水野隆一 向井万起男 岡田保典
  • Organizer: 第１００回日本病理学会総会
  • Place of Presentation: 横浜