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EMT-targeted molecular therapy for renal cell carcinoma

Research Project

Project/Area Number 23790417
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Human pathology
Research InstitutionKeio University

Principal Investigator

MIKAMI Shuji  慶應義塾大学, 医学部, 助教 (20338180)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords上皮-間葉転換 / 腎細胞癌 / TNF-α / 転移 / 分子標的薬 / 浸潤 / 分子標的治療 / 癌幹細胞 / 上皮ー間葉転換 / TNF
Research Abstract

TNF-α and CD44 were expressed in carcinoma cells of high-grade clear cell renal cell carcinomas (ccRCCs) and the expression levels showed positive correlation with primary tumor stage and distant metastasis. Elevated expression of TNF-α and CD44 was pr

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (17 results)

All 2012 2011 Other

All Journal Article (13 results) (of which Peer Reviewed: 13 results) Presentation (4 results)

  • [Journal Article] The prognostic significance of vasohibin-1 expression in patients with upper urinary tract urothelial carcinoma2012

    • Author(s)
      Miyazaki Y, Kosaka T, Mikami S, Kikuchi E, Tanaka N, Maeda T, Ishida M, Miyajima A, Nakagawa K, Okada Y, Sato Y, Oya M
    • Journal Title

      Clin Cancer Res

      Volume: 18 Pages: 4145-53

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic role of KiSS-1 and possibility of therapeutic modality of metastin, the final peptide of the KiSS-1 gene, in urothelial carcinoma.2012

    • Author(s)
      Takeda T, Kikuchi E, Mikami S, Suzuki E, Matsumoto K, Miyajima A, Okada Y, Oya M
    • Journal Title

      Mol Cancer Ther

      Volume: 11 Pages: 853-63

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tumor cell-derived angiopoietin-like protein ANGPTL2 is a critical driver of metastasis2012

    • Author(s)
      Endo M, Nakano M, Kadomatsu T, Fukuhara S, Kuroda H, Mikami S, Hato T, Aoi J, Horiguchi H, Miyata K, Odagiri H, Masuda T, Harada M, Horio H, Hishima T, Nomori H, Ito T, Yamamoto Y, Minami T, Okada S, Takahashi T, Mochizuki N, Iwase H, Oike Y
    • Journal Title

      Cancer Res

      Volume: 72(7) Pages: 1784-94

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of monocyte chemoattractant protein-1 through angiotensin II type 1 receptor in prostate cancer2012

    • Author(s)
      Shirotake S, Miyajima A, Kosaka T, Tanaka N, Kikuchi E, Mikami S, Okada Y, Oya M
    • Journal Title

      Am J Pathol

      Volume: 180 Pages: 1008-16

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic significance of high nuclear grade in patients with pathologic T1a renal cell carcinoma.2012

    • Author(s)
      Suzuki K, Mizuno R, Mikami S, Tanaka N, Kanao K, Kikuchi E, Miyajima A, Nakagawa K, Oya M
    • Journal Title

      Jpn J Clin Oncol

      Volume: 42 Pages: 831-5

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Multilocular cystic renal cell carcinoma with focus on clinical and pathobiological aspects.2012

    • Author(s)
      Kuroda N, Ohe C, Mikami S, Inoue K,Nagashima Y, Cohen RJ, Pan CC, Michal M, Hes O
    • Journal Title

      Histol Histopathol.

      Volume: 27(8) Pages: 969-74

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Patterns of interstitial lung disease during everolimus treatment in patients with metastatic renal cell carcinoma2012

    • Author(s)
      Mizuno R, Asano K, Mikami S, Nagata H, Kaneko G, Oya M
    • Journal Title

      Jpn J Clin Oncol

      Volume: 42 Pages: 442-6

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The prognostic significance of vasohibin-1 expression in patients with upper urinary tracturothelial carcinoma2012

    • Author(s)
      Miyazaki Y, Kosaka T, Mikami S, Kikuchi E, Tanaka N, Maeda T, Ishida M, Miyajima A, Nakagawa K, Okada Y, Sato Y, Oya M
    • Journal Title

      Clin Cancer Res

      Volume: 18 Issue: 15 Pages: 4145-4153

    • DOI

      10.1158/1078-0432.ccr-12-0073

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic role of KiSS-1 and possibility of therapeutic modality of metastin, the final peptide of the KiSS-1 gene, in urothelial carcinoma2012

    • Author(s)
      Takeda T
    • Journal Title

      Mol Cancer Ther

      Volume: 11 Issue: 4 Pages: 853-863

    • DOI

      10.1158/1535-7163.mct-11-0521

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of Snail and Slug in renal cell carcinoma: E-cadherin repressor Snail is associated with cancer invasion and prognosis.2011

    • Author(s)
      Mikami S, Katsube K, Oya M, Ishida M, Kosaka T, Mizuno R, Mukai M, Okada Y
    • Journal Title

      Lab Invest

      Volume: 91 Pages: 1443-58

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clear cell adenocarcinoma arising in endometrial adenofibroma2011

    • Author(s)
      Mikami S, Kikunaga H, Kameyama K, Mukai M
    • Journal Title

      Pathol Int

      Volume: 61(3) Pages: 167-70

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Clinical Impact of the Classification of Carcinoma In Situ on Tumor Recurrence and their Clinical Course in Patients with Bladder Tumor2011

    • Author(s)
      Hayakawa N, Kikuchi E, Mikami S, Matsumoto K, Miyajima A, Oya M
    • Journal Title

      Jpn. J Clin Oncol

      Volume: 41(3) Pages: 424-9

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intra-sellar Salivary Gland-like Pleomorphic Adenoma.2011

    • Author(s)
      Takahashi S, Mikami S, Akiyama T, Kawase T
    • Journal Title

      Neurosurgery

      Volume: 68(2) Pages: 562-5

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] 腎細胞癌の異型性と浸潤・転移2012

    • Author(s)
      三上修治、大家基嗣、勝部憲ー、向井万起男、岡田保典
    • Organizer
      第44回日本臨床分子形態学会総会。シンポジウム:腎がん研究の分子形態学的アプローチ
    • Place of Presentation
      高知
    • Related Report
      2012 Final Research Report
  • [Presentation] 腎細胞癌におけるADAM17発現の意義2012

    • Author(s)
      三上修治 、大家基嗣、石田勝、水野隆一、向井万起男、岡田保典
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 腎細胞癌の異型性と浸潤・転移2012

    • Author(s)
      三上 修治
    • Organizer
      第44回日本臨床分子形態学会総会。シンポジウム:腎がん研究の分子形態学的アプローチ
    • Place of Presentation
      高知
    • Related Report
      2012 Annual Research Report
  • [Presentation] 腎細胞癌におけるEMT誘導因子TNF-発現の意義および機能解析

    • Author(s)
      三上修治 大家基嗣 石田勝 小坂威男 水野隆一 向井万起男 岡田保典
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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