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The significance of Caveolin-1 in experimental kidney disease

Research Project

Project/Area Number 23790423
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Human pathology
Research InstitutionJikei University School of Medicine

Principal Investigator

YAMAMOTO Izumi  東京慈恵会医科大学, 医学部, 助教 (60600468)

Project Period (FY) 2011-04-28 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords実験腎炎 / カベオリン / Caveolin-1 / 尿細管間質線維化 / マクロファージ / カベオリン1 / 腎障害モデル / 移植腎病理 / 間質線維化 / 血管内皮細胞
Outline of Final Research Achievements

To evaluate the significance of Caveolin-1 in kidney disease, we investigated several experimental kidney disease model using Caveolin-1 knockout, transgenic and wild type mouse.Ischemia reperfusion injury model, unilateral ureteral obstruction (UUO) model, eNOS inhibitor infusion model and anti-VEGF antibody infusion model were applied for this purpuse. We found that each model showed no remarkable change regarding Caveolin-1 expression and Caveolae formation on endothelial cells.Only UUO model and eNOS inhibitor infusion model showed increased tubulointerstitial fibrosis in Caveolin-1 knockout mouse compared with wild type mouse. Further examination revealed that only UUO model showed increased macrophage infiltration compared with wild type mouse.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (2 results)

All 2015 2014

All Presentation (2 results)

  • [Presentation] 慢性抗体関連型拒絶反応のCaveolin-1とC4d染色性と移植腎予後2015

    • Author(s)
      中田泰之、山本泉、小林賛光、山川貴史、勝俣陽貴、丹野有道、山本裕康
    • Organizer
      日本臨床腎移植学会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-02-04 – 2015-02-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 慢性抗体関連型拒絶反応症例におけるPTCのC4dおよびCaveolin-1染色性と移植腎予後の検討2014

    • Author(s)
      中田泰之、山本泉、小林賛光、山川貴史、勝俣陽貴、丹野有道、山本裕康
    • Organizer
      移植腎病理研究会
    • Place of Presentation
      東京
    • Year and Date
      2014-07-19
    • Related Report
      2014 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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