| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
To evaluate the significance of Caveolin-1 in kidney disease, we investigated several experimental kidney disease model using Caveolin-1 knockout, transgenic and wild type mouse.Ischemia reperfusion injury model, unilateral ureteral obstruction (UUO) model, eNOS inhibitor infusion model and anti-VEGF antibody infusion model were applied for this purpuse. We found that each model showed no remarkable change regarding Caveolin-1 expression and Caveolae formation on endothelial cells.Only UUO model and eNOS inhibitor infusion model showed increased tubulointerstitial fibrosis in Caveolin-1 knockout mouse compared with wild type mouse. Further examination revealed that only UUO model showed increased macrophage infiltration compared with wild type mouse.
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