Regulation of JC virus late gene expression
Project/Area Number |
23790429
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Experimental pathology
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Research Institution | Hokkaido University |
Principal Investigator |
ORBA Yasuko 北海道大学, 人獣共通感染症リサーチセンター, 特任助教 (60507169)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | JCウイルス / RNA / 脳神経疾患 / JCウイルス / ウイルス |
Research Abstract |
JC virus(JCV) late transcripts, which produce agnoprotein, VP1, VP2, and VP3, are polycistronic mRNAs and processed by alternative splicing. We found that JCV late transcripts are processed into mature mRNAs using a unique splicing mechanism. Analysis of virus infection using JCV genomes with splice site mutations indicated that the identified splicing mechanism is necessary for efficient production of late proteins and viral infection.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Relationship between Methyl CpG Binding Protein 2 and JC Viral Proteins2013
Author(s)
Takahashi K, Orba Y, Kimura T, Wang L, Kohsaka S, Tsuda M, Tanino M, Nishihara H, Nagashima K, Sawa H, Tanaka S
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Journal Title
Japanese Journal of Infectious Diseases
Volume: 66
Issue: 2
Pages: 126-132
DOI
NAID
ISSN
1344-6304, 1884-2836
Related Report
Peer Reviewed
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[Journal Article] Identification of a novel polyomavirus from vervet monkeys in Zambia.2013
Author(s)
Yamaguchi H, Kobayashi S, Ishii A, Ogawa H, Nakamura I, Moonga L, Hang'ombe BM, Mweene AS, Thomas Y, Kimura T, Sawa H, Orba Y.
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Journal Title
J Gen Virol.
Volume: 94(Pt 6)
Issue: 6
Pages: 1357-64
DOI
Related Report
Peer Reviewed
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[Journal Article] Cysteine Residues in the Major Capsid Protein, Vp1, of the JC Virus Are Important for Protein Stability and Oligomer Formation2013
Author(s)
Kobayashi S, Suzuki T, Igarashi M, Orba Y, Ohtake N, Nagakawa K, Niikura K, Kimura T, Kasamatsu H, Sawa H
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Journal Title
PLoS One
Volume: 8(10)
Issue: 10
Pages: e76668-e76668
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Relationship between methyl CpG binding protein 2 and JC viral proteins.2013
Author(s)
Takahashi K, Orba Y, Kimura T, Wang L, Kohsaka S, Tsuda M, Tanino M, Nishihara H, Nagashima K, Sawa H, Tanaka S.
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Journal Title
Jpn J Infect Dis.
Volume: 66(2)
Pages: 126-32
NAID
Related Report
Peer Reviewed
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