| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
We have shown that characteristics of tumor vasculature can determine the intractability of tumors, and that manipulation of the vasculature characteristics can improve the efficacy of nanoDDS in the animal models of pancreatic and gastric cancers. In this study we focused on a protein, known to be expressed in neovasculature and stabilizing endothelial-mural cell attachment. The protein was suggested to play an important role in the mechanism of extravasation of nanoDDS from tumor vasculature.
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