The elucidation of carcinogenic mechanism by two-stage skin carcinogenesis in CENP-R null mice
| Project/Area Number |
23790435
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental pathology
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| Research Institution | Chiba Cancer Center (Research Institute) |
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Principal Investigator |
OKUMURA Kazuhiro 千葉県がんセンター(研究所), 発がん研究グループ・実験動物研究室, 研究員 (80584680)
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| Research Collaborator |
WAKABAYASHI Yuichi 千葉県がんセンター研究所, 発がん研究グループ・実験動物研究室, 室長 (40303119)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | セントロメア / CENP-R / ノックアウトマウス / DMBA-TPA / Cenpr / 染色体 / DMBA/TPA / 皮膚発がん |
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| Research Abstract |
To reveal the function of CENP-R in skin carcinogenesis, we subjected 30 CENP-R knockout (CENP-R^<-/->) mice, 15 CENP-R＾<+/+> mice as control groups, to the DMBA/TPA chemical carcinogenesis protocol and monitored their tumor development for a period of 38 weeks. As a result, control mice had a higher incidence and earlier onset of squamous cell carcinoma compared to CENP-R^<-/-> mice. Therefore, CENP-R is important factor for skin carcinogenesis
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Report
(3 results)
Research Products
(10 results)
