Regulatory mechanism of signal transduction involved in cytokine production from basophils and the control of type 2 immune response.

• Project/Area Number: 23790438
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Experimental pathology
• Research Institution: Shinshu University
• Principal Investigator: SANJO Hideki 信州大学, 医学部, 助教 (50391967)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 好塩基球伝達 / サイトカイン / シグナル / 好塩基球 / シグナル伝達

Research Abstract

The aim of this study is to reveal the unknown molecular mechanisms of signaling pathway that regulate activation of basophils, important for type 2 immune response, as well as cytokine production.
As a result the regulatory mechanisms were evident that the resting basophils restrain the signal transduction via FcεRI, a receptor for IgE, by negatively regulating the protein levels of signaling molecules and Bcl6, known as transcriptional corepressor
negatively regulates cytokine production induced by FcεRI crosslinking in the resting basophils.

Research Products

• [Journal Article] Essential Roles of K63-Linked Polyubiquitin-Binding Proteins TAB2 and TAB3 in B Cell Activaion via MAPKs. (2013)
  • Author(s): Ori D
  • Journal Title: J Immunol Volume: 190(8) Issue: 8 Pages: 4037-4045
  • DOI: 10.4049/jimmunol.1300173
  • Peer Reviewed
• [Journal Article] Differential requirements for IFN regulatory factor-2 in generation of CD1d-independent T cells bearing NK cell receptors (2012)
  • Author(s): Notake T, Horisawa S, Sanjo H, Miyagawa S, Hida S, Taki S.
  • Journal Title: J. Immunol Volume: 188 Issue: 10 Pages: 4838-4845
  • DOI: 10.4049/jimmunol.1200210
  • Peer Reviewed
• [Journal Article] Differential requirements for IRF-2 in generation of CD1d-independent T cells bearing NK cell receptors. (2012)
  • Author(s): Notake T, Horisawa S, Sanjo H, Miyagawa S, Hida S, Taki S.
  • Journal Title: Journal of Immunology Volume: 188 Pages: 4838-4845
  • Peer Reviewed
• [Presentation] Paxillin wasrequired for IL-3-induced IL-4 production in basophils. (2012)
  • Author(s): Hasegawa A., Hida S., Sanjo H., Oda A., Taki S., Taniguchi S.
  • Organizer: 日本免疫学会
  • Place of Presentation: 神戸
  • Year and Date: 2012-12-06
• [Presentation] Essential roles of Tab2 and Tab3 in the activation of MAPK but not NF-kB, in B cells. (2012)
  • Author(s): Ori D., Kato H., Sanjo H., Akira S., Takeuchi O.
  • Organizer: 日本免疫学会
  • Place of Presentation: 神戸
  • Year and Date: 2012-12-05
• [Presentation] IL-3-induced IL-13 production by basophils but not mast cells was sensitive to Paired immunoglobulin-like receptor(PIR)-B mediated inhibitory signals. (2011)
  • Author(s): Oda A., Sakamoto Y., Sanjo H., Notake T., Takai T., Hida S., Taki S.
  • Organizer: 日本免疫学会
  • Place of Presentation: 千葉
  • Year and Date: 2011-11-29
• [Presentation] IL-15-independent generation of memory-like 'innate'CD8+ T cells in IRF-2 deficient mice. (2011)
  • Author(s): Notake T., Oda A., Sanjo H., Hida S., Taki S
  • Organizer: 日本免疫学会
  • Place of Presentation: 千葉
  • Year and Date: 2011-11-28
• [Presentation] Essential roles of Tab2 and Tab3 in the activation of MAPK, but not NF-kB, in B cells.
  • Author(s): Ori D, Kato H, Sanjo H, Akira S, Takeuchi O.
  • Organizer: 日本免疫学会
  • Place of Presentation: 神戸
• [Presentation] Paxillin was required for IL-3-induced IL-4 production in basophils.
  • Author(s): Hasegawa A, Hida S, Sanjo H, Oda A, Taki S, Taniguchi S.
  • Organizer: 日本免疫学会
  • Place of Presentation: 神戸