Regulatory mechanism of signal transduction involved in cytokine production from basophils and the control of type 2 immune response.
| Project/Area Number |
23790438
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Experimental pathology
|
|---|
| Research Institution | Shinshu University |
|---|
Principal Investigator |
SANJO Hideki 信州大学, 医学部, 助教 (50391967)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 好塩基球伝達 / サイトカイン / シグナル / 好塩基球 / シグナル伝達 |
|---|
| Research Abstract |
The aim of this study is to reveal the unknown molecular mechanisms of signaling pathway that regulate activation of basophils, important for type 2 immune response, as well as cytokine production.
As a result the regulatory mechanisms were evident that the resting basophils restrain the signal transduction via FcεRI, a receptor for IgE, by negatively regulating the protein levels of signaling molecules and Bcl6, known as transcriptional corepressor
negatively regulates cytokine production induced by FcεRI crosslinking in the resting basophils.
|
Report
(3 results)
Research Products
(9 results)
