An investigation into functional roles of microRNA inthe animal model of malignant peritoneal mesothelioma
| Project/Area Number |
23790440
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental pathology
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | microRNA / 動物モデル / 悪性中皮腫 / 鉄化合物 / アスベスト / Twist-1 / 中皮腫 / 酸化ストレス |
|---|
| Research Abstract |
Preliminary experiment of microRNA (miRNA) microarray disclosed miRNA-199/214 as a hallmark of iron saccharate-induced sarcomatoid malignant mesothelioma. With the aid of this grant, elevation of miRNA-199/214 was confirmed by real-time PCR and ISH. Twist-1, which transcribes miRNA-199/214, was detected in sacromatoid mesothelioma and asbestos-induced malignant peritoneal mesothelioma and cultured cell lines. Transfection of miR-199/214 into immortalized mesothelial cell line increased cell growth, providing evidence of a functional role of miRNA-199/214.
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Report
(3 results)
Research Products
(35 results)
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[Journal Article] Diameter and rigidity of multi-walled carbon nanotubes are critical factors in mesothelial injury and carcinogenesis2011
Author(s)
Nagai H, Okazaki Y, Chew SH, Misawa N, Yamashita Y, Akatsuka S, Ishihara T, Yamashita K, Yoshikawa Y, Yasui H, Jiang L, Ohara H, Takahashi T, Ichihara G, Kostarelos K, Miyata Y, Shinohara H, *Toyokuni S
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Journal Title
Proc Natl Acad Sci USA
Volume: 108(49)
Related Report
Peer Reviewed
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[Presentation]2012
Author(s)
岡崎泰昌
Organizer
第71回日本癌学会学術総会
Place of Presentation
札幌
Related Report
-
[Presentation]2012
Author(s)
岡崎泰昌
Organizer
第36回鉄バイオサイエンス学会
Place of Presentation
札幌
Related Report
-
[Presentation]2012
Author(s)
岡崎泰昌
Organizer
第65回酸化ストレス学会学術集会
Place of Presentation
徳島
Related Report
-
[Presentation]2012
Author(s)
岡崎泰昌
Organizer
第101回日本病理学会総会
Place of Presentation
東京
Related Report
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[Presentation]2011
Author(s)
岡崎泰昌
Organizer
第2回JMIG研究会
Place of Presentation
大阪
Year and Date
2011-01-28
Related Report
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[Presentation]2011
Author(s)
岡崎泰昌
Organizer
第70回日本癌学会学術総会
Place of Presentation
名古屋
Related Report
-
[Presentation]2011
Author(s)
岡崎泰昌
Organizer
第35回鉄バイオサイエンス学会
Place of Presentation
東京
Related Report
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[Presentation]2011
Author(s)
岡崎泰昌
Organizer
第64回酸化ストレス学会学術集会
Place of Presentation
留寿都
Related Report
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[Presentation]2011
Author(s)
岡崎泰昌
Organizer
第100回日本病理学会総会
Place of Presentation
東京
Related Report
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[Presentation] DETECTION AND FUNCTIONAL ANALYSES OF microRNA IN HIGH-GRADE PHENOTYPE OF IRON SACCHARATE-INDUCED MESOTHELIOMA IN RATS.2011
Author(s)
Yasumasa Okazaki, Hu Qian, Shinya Akatsuka, Kyoko Yamashita, Satomi Funahashi, Yoriko Yamashita, Li Jiang, Hiroki Ohara, Chew Shan Hwu, Hirotaka Nagai, Takashi Takahashi, Shinya Toyokuni
Organizer
5th Biennial Meeting of SFRR (Society for Free Radical Research) Asia
Place of Presentation
鹿児島市民文化ホール（鹿児島県）
Related Report
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[Presentation] Detection and functional analyses of microRNA in high-grade phenotype of iron saccharate-induced sarcomatoid mesothelioma in rats2011
Author(s)
Yasumasa Okazaki, Hu Qian, Shinya Akatsuka, Kyoko Yamashita, Satomi Funahashi, Yoriko Yamashita, Jiang Li, Hiroki Ohara, Chew Shan Hwu, Hirotaka Nagai, Takashi Takahashi, Shinya Toyokuni
Organizer
第70回癌学会
Place of Presentation
名古屋国際会議場（愛知県）
Related Report
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