| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
The main cause of death in influenza viral infection is secondary bacterial pneumonia. The expression of SET domain bifurcated 2 (SETDB2), an enzyme which leads to gene depression, was increased in both macrophages and bronchial epithelial cells, followed bytype-I interferon (an essential cytokine against viral infection) and influenza viral stimulation itself. The expression of SETDB2is type-I interferon (IFN-I) dependent, and IFN-I receptor knockout mice improved a significant survival compared with wild-type mice in secondary bacterial infectious model. There results suggest that SETDB2 has the potential to be a clinical key to prevent secondary bacterial pneumonia following influenza viral infection.
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