Role of hapten-specific IgE in allergen diversification

• Project/Area Number: 23790450
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Experimental pathology
• Research Institution: Hyogo Medical University
• Principal Investigator: YASUDA Koubun 兵庫医科大学, 医学部, 講師 (50333539)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 疾患モデル動物 / アレルギー / IgE / 好塩基球 / IL-4 / ハプテン / Th2誘導

Research Abstract

When a hapten specific IgE binds hapten-labeled protein antigen, it acts as adjuvant to induce the carrier protein antigen specific IgE. By stimulation with IgE / antigen immune complex on FcRIα, basophil produces IL-4 and presents antigen to CD4+T cells to induce Th2. Thus, an allergen can diversify Th2 / IgE repertoire by hapten-specific IgE.

Research Products

• [Journal Article] IgG and IgE Collaboratively Accelerate Expulsion of Strongyloides venezuelensisin a Primary Infection. (2013)
  • Author(s): Matsumoto M, Sasaki Y, Yasuda K, Takai T, Muramatsu M, Yoshimoto T, Nakanishi K
  • Journal Title: Infect Immun. Volume: 81(7) Pages: 2518-27
  • Peer Reviewed
• [Journal Article] IgG and IgE collaboratively accelerate expulsion of Strongyloides venezuelensis in a primary infection. (2013)
  • Author(s): Makoto Matsumoto, Yuki Sasaki, Koubun Yasuda, Toshiyuki Takai, Masamichi Muramatsu, Tomohiro Yoshimoto, Kenji Nakanishi.
  • Journal Title: Infection and Immunity Volume: Vol.81、No.7 Issue: 7 Pages: 2518-2527
  • DOI: 10.1128/iai.00285-13
  • Peer Reviewed
• [Journal Article] 寄生虫感染と宿主粘膜免疫の攻防におけるIL-33とII型自然リンパ系細胞の役割 (2012)
  • Author(s): 安田好文.
  • Journal Title: 実験医学 Volume: 30(20) Pages: 165-71
• [Journal Article] 自然免疫による好酸球性肺炎発症機構 (2012)
  • Author(s): 安田好文,中西憲司.
  • Journal Title: 医学のあゆみ Volume: 243(1) Pages: 91-7
• [Journal Article] 蠕虫の排除と自然免疫・獲得免疫 (2012)
  • Author(s): 安田好文,中西憲司.
  • Journal Title: 臨床免疫・アレルギー科 Volume: 57(3) Pages: 307-15
  • NAID: 40019255867
• [Journal Article] Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice (2012)
  • Author(s): 安田好文, 他
  • Journal Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 109 Issue: 9 Pages: 3451-3456
  • DOI: 10.1073/pnas.1201042109
  • Peer Reviewed
• [Journal Article] 自然免疫による好酸球性肺炎発症機構 (2012)
  • Author(s): 安田好文
  • Journal Title: 医学のあゆみ Volume: 243巻1号 Pages: 91-97
• [Journal Article] 寄生虫感染と宿主粘膜免疫の攻防におけるIL-33とII型自然リンパ系細胞の役割 (2012)
  • Author(s): 安田好文
  • Journal Title: 実験医学増刊 Volume: 30(20) Pages: 3323-3329
• [Presentation] Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia inStrongyloides venezuelensis-infected mice. Keystone Symposia, Type 2 Immunity: Initiation, Maintenance (2013)
  • Author(s): Yasuda K, Muto T, Matsumoto M, Yoshimoto T, Nakanishi K.
  • Organizer: Homeostasis and Pathology
  • Place of Presentation: Santa Fe, NM, USA
• [Presentation] Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in Strongyloides venezuelensis-infected mice (2013)
  • Author(s): Koubun Yasuda
  • Organizer: Keystone Symposia, Type 2 Immunity: Initiation, Maintenance, Homeostasis and Pathology
  • Place of Presentation: Santa Fe, NM, USA
• [Presentation] Contibution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in Strongyloides venezuelensis-infected mice (2012)
  • Author(s): Yasuda K, Muto T, Kawagoe T, Matsumoto M, Sasaki Y, Matsushita K, Futatsugi -Yumikura S, Tsutsui H, Ishii K, Yoshimoto T, Akira S, Nakanishi K.
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸
• [Presentation] 蠕虫感染による好酸球性肺炎は自然免疫応答で誘導される (2012)
  • Author(s): 安田好文,武藤太一朗,松本真琴,中西憲司.
  • Organizer: 第68回日本寄生虫学会西日本支部大会
  • Place of Presentation: 奈良
• [Presentation] Contribution of IL-33 activated natural helper cells to IL-5 production and eosinophil accumulation in intestinal nematode infected mice (2012)
  • Author(s): Yasuda K, Muto T, Kawagoe T, MatsumotoM, Sasaki Y, Matsushita K Futatsugi -Yumikura S, Tsutsui H, Ishii K, Yoshimoto T, Akira S, Nakanishi K.
  • Organizer: The 34th Naito Conference
  • Place of Presentation: 札幌
• [Presentation] Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematodeinfected mice (2012)
  • Author(s): Yasuda K, Muto T, Kawagoe T, Matsumoto M, Sasaki Y, Matsushita K, Taki Y, Futatsugi-Yumikura S, Tsutsui H, Ishi K, Yoshimoto T, Akira S, Nakanishi K.
  • Organizer: 第77回日本インターフェロン・サイトカイン学会学術集会
  • Place of Presentation: 神戸
• [Presentation] 糞線虫感染時に肺でみられる好酸球性炎症発症機序の解析.(シンポジウム) (2012)
  • Author(s): 安田好文.
  • Organizer: 第81回日本寄生虫学会
  • Place of Presentation: 西宮
• [Presentation] Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode infected mice (2012)
  • Author(s): Yasuda K.
  • Organizer: The 5thImmunoparasitology Meeting
  • Place of Presentation: Osaka
• [Presentation] Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice (2012)
  • Author(s): Koubun Yasuda
  • Organizer: 第77回日本インターフェロン・サイトカイン学会
  • Place of Presentation: 神戸
• [Presentation] 蠕虫感染による好酸球性肺炎は自然免疫応答で誘導される (2012)
  • Author(s): 安田好文
  • Organizer: 第６８回日本寄生虫学会西日本支部大会
  • Place of Presentation: 奈良
• [Presentation] Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in Strongyloides venezuelensis-infected mice (2012)
  • Author(s): Koubun Yasuda
  • Organizer: 第41回日本免疫学会総会・学術集会
  • Place of Presentation: 神戸
• [Presentation] Contribution of IL-33 activated natural helper cells to IL-5 production and eosinophil accumulation in intestinal nematode infected mice (2012)
  • Author(s): Koubun Yasuda
  • Organizer: 第81回日本寄生虫学会大会シンポジウム
  • Place of Presentation: 兵庫
• [Presentation] Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice (2012)
  • Author(s): Koubun Yasuda
  • Organizer: The 5th Immunoparasitology Meeting
  • Place of Presentation: 大阪
• [Presentation] サイトカイン産生細胞としての好塩基球、好酸球の機能解析.テクニカルセミナー (2011)
  • Author(s): 安田好文
  • Organizer: 第40回日本免疫学会会・学術集会
  • Place of Presentation: 千葉
• [Presentation] Contribution of IL-33 activated natural helper / nuocyte-like cells to IL-5 production and eosinophil accumulation in intestinal nematode infected mice (2011)
  • Author(s): 安田好文, 武藤太一朗, 今井康友, 松本真琴, 佐々木由紀, 高城ゆう子, 弓倉静英, 善本知広,中西憲司
  • Organizer: 第40回日本免疫学会総会・学術集会
  • Place of Presentation: 千葉
• [Presentation] IL-33 mediated expulsion of Nippostrongylus brasiliensis and Stongyloides venezuelensisInternational Union of Microbiological Societies (2011)
  • Author(s): Yasuda K, Sasaki Y, Matsumoto M, Taki Y, Yoshimoto T, Nakanishi K.
  • Organizer: 2011 congress.
  • Place of Presentation: 札幌
• [Presentation] IL-33 mediated expulsion of Nippostrongylus brasiliensis and Strongyloides venezuelensis (2011)
  • Author(s): 安田好文, 佐々木由紀, 松本真琴, 高城ゆう子, 善本知広, 中西憲司
  • Organizer: 第80回日本寄生虫学会大会
  • Place of Presentation: 東京
• [Presentation] IL-33 mediated expulsion of Nippostrongylus brasiliensis and Strongyloidesvenezuelensis (2011)
  • Author(s): Yasuda K, Sasaki Y, Matsumoto M, Taki Y, Yoshimoto T, Nakanishi K.
  • Organizer: The Joint International Meeting Sponsored by The Japanese Society for Interferon and Cytokine Research and The Japanese Society for Macrophage Molecular and Cell Biology (JSICR-MMCB2011)
  • Place of Presentation: Osaka
• [Presentation] IL-33 mediated expulsion of Nippostrongylus brasiliensis and Strongyloides venezuelensis. (2011)
  • Author(s): Koubun Yasuda, Yuki Sasaki, Makoto Matsumoto, Yuuko Taki, Tomohiro Yoshimoto, Kenji Nakanishi
  • Organizer: 第７６回日本インターフェロン・サイトカイン学会学術集会 第１９回マクロファージ分子細胞生物学国際シンポジウム
  • Place of Presentation: 大阪
• [Presentation] IL-33 mediated expulsion of Nippostrongylus brasiliensis and Strongyloides venezuelensis. (2011)
  • Author(s): Koubun Yasuda, Yuki Sasaki, Makoto Matsumoto, Yuuko Taki, Tomohiro Yoshimoto, Kenji Nakanishi
  • Organizer: 第80回日本寄生虫学会大会
  • Place of Presentation: 東京
• [Presentation] サイトカイン産生細胞としての好塩基球、好酸球の機能解析 (2011)
  • Author(s): 安田好文
  • Organizer: 第40回日本免疫学会総会・学術集会（ランチョンセミナー）
  • Place of Presentation: 千葉
• [Book] Th2アジュバントの作用機序と臨床応用.石井健,山西弘一監修.アジュバント開発研究の新展開.東京 (2011)
  • Author(s): 安田好文,中西憲司
  • Publisher: シーエムシー出版
• [Book] アジュバント研究開発の新展開 (2011)
  • Author(s): 安田好文、中西憲司（監修：石井健、山西弘一）
  • Publisher: シーエムシー出版
• [Remarks]
  • URL: http://www.hyo-med.ac.jp/department/immn/page/flame-set.html