Role of hapten-specific IgE in allergen diversification
| Project/Area Number |
23790450
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental pathology
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
YASUDA Koubun 兵庫医科大学, 医学部, 講師 (50333539)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 疾患モデル動物 / アレルギー / IgE / 好塩基球 / IL-4 / ハプテン / Th2誘導 |
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| Research Abstract |
When a hapten specific IgE binds hapten-labeled protein antigen, it acts as adjuvant to induce the carrier protein antigen specific IgE. By stimulation with IgE / antigen immune complex on FcRIα, basophil produces IL-4 and presents antigen to CD4+T cells to induce Th2. Thus, an allergen can diversify Th2 / IgE repertoire by hapten-specific IgE.
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Report
(3 results)
Research Products
(32 results)
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[Presentation] Contibution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in Strongyloides venezuelensis-infected mice2012
Author(s)
Yasuda K, Muto T, Kawagoe T, Matsumoto M, Sasaki Y, Matsushita K, Futatsugi -Yumikura S, Tsutsui H, Ishii K, Yoshimoto T, Akira S, Nakanishi K.
Organizer
第41回日本免疫学会学術集会
Place of Presentation
神戸
Related Report
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[Presentation] Contribution of IL-33 activated natural helper cells to IL-5 production and eosinophil accumulation in intestinal nematode infected mice2012
Author(s)
Yasuda K, Muto T, Kawagoe T, MatsumotoM, Sasaki Y, Matsushita K Futatsugi -Yumikura S, Tsutsui H, Ishii K, Yoshimoto T, Akira S, Nakanishi K.
Organizer
The 34th Naito Conference
Place of Presentation
札幌
Related Report
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[Presentation] Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematodeinfected mice2012
Author(s)
Yasuda K, Muto T, Kawagoe T, Matsumoto M, Sasaki Y, Matsushita K, Taki Y, Futatsugi-Yumikura S, Tsutsui H, Ishi K, Yoshimoto T, Akira S, Nakanishi K.
Organizer
第77回日本インターフェロン・サイトカイン学会学術集会
Place of Presentation
神戸
Related Report
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