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Epigenetic mechanism of chronic inflammation-associated human carcinogenesis

Research Project

Project/Area Number 23790456
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Experimental pathology
Research InstitutionNational Cancer Center Japan

Principal Investigator

ARAI Eri  独立行政法人国立がん研究センター, 研究所, 研究員 (40446547)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords分子病理 / 腫瘍 / DNA メチル化 / 炎症 / DNAメチル化 / 前がん状態 / 慢性炎症 / 多段階発がん
Research Abstract

This study has focused on the significance of epigenome alterations in multistage carcinogenesis associated with chronic inflammation. Genome-wide DNA methylation analysis was performed in cancerous and non-cancerous tissue samples obtained from patients with adenocarcinomas of the lung. For comparison, normal lung tissue samples from patients without any primary lung tumor were also analyzed. DNA methylation profiles, which may generate aggressive adenocarcinomas from the inflammatory background in chronic obstructive pulmonary disease in heavy smokers, were identified. Genome-wide DNA methylation analysis also identified DNA methylation profiles each specific to hepatocarcinogenesis associated with hepatitis B virus (HBV) infection and hepatitis C virus infection (HCV) and DNA methylation profiles shared by HBV-positive and HCV-positive patients.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (49 results)

All 2013 2012 2011 Other

All Journal Article (13 results) (of which Peer Reviewed: 13 results) Presentation (31 results) (of which Invited: 1 results) Book (3 results) Remarks (2 results)

  • [Journal Article] Prognostic risk stratification of patients with urothelial carcinoma of the bladder with recurrence after radical cystectomy2013

    • Author(s)
      Nakagawa T, Hara T, Kawahara T, Ogata Y, Nakanishi H, Komiyama M, Arai E, Kanai Y, Fujimoto H
    • Journal Title

      J Urol

      Volume: 189 Issue: 4 Pages: 1275

    • DOI

      10.1016/j.juro.2012.10.065

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ability of preoperative 3.0-Tesla magnetic resonance imaging to predict the absence of side-specific extracapsular extension of prostate cancer2013

    • Author(s)
      Hara T, Nakanishi H, Nakagawa T, Komiyama M, Kawahara T, Manabe T, Miyake M, Arai E, Kanai Y, Fujimoto H
    • Journal Title

      Int J Urol

      Volume: 20 Issue: 10 Pages: 993

    • DOI

      10.1111/iju.12091

    • URL

      https://pure.teikyo.jp/en/publications/81acb57f-eaa2-4f40-b944-9713730ba3d7

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] DNA methylation profiles at precancerous stages associated with recurrence of lung adenocarcinoma.2013

    • Author(s)
      Sato T, Arai E, Kohno T, Tsuta K, Watanabe S, Soejima K, Betsuyaku T, Kanai Y.
    • Journal Title

      PLOS One

      Volume: 8(3) Issue: 3 Pages: e59444-e59444

    • DOI

      10.1371/journal.pone.0059444

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fenton Reaction Induced Cancer in Wild Type Rats Recapitulates Genomic Alterations Observed in Human Cancer2012

    • Author(s)
      Liu Y, Izumiya M, Abe K, Ochiai M, Jiang L, Nagai H, Okazaki Y, Murakami H, Sekido Y, Arai E, Kanai Y, Hino O, Takahashi T, Nakagama H, Toyokuni S
    • Journal Title

      PLoS One

      Volume: 7 Issue: 8 Pages: e43403-e43403

    • DOI

      10.1371/journal.pone.0043403

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] DNA methyltransferase 3B expression is associated with poor outcome of stage I testicular seminoma2012

    • Author(s)
      Aral E, Kanai Y, et al
    • Journal Title

      Histopathology

      Volume: 60 Issue: 6 B

    • DOI

      10.1111/j.1365-2559.2012.04174.x

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Single-CpG-resolution methylome analysis identifies clinicopathologically aggressive CpG island methylator phenotype clear cell renal cell carcinomas2012

    • Author(s)
      Arai E, Kanai Y et al.
    • Journal Title

      Carcinogenesis

      Volume: 33 Issue: 8 Pages: 1487

    • DOI

      10.1093/carcin/bgs177

    • URL

      https://pure.teikyo.jp/en/publications/90941130-1163-479d-839c-affd7ca06e8b

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Single-CpG-resolution methylome analysis identifies clinicopathologically aggressive CpG island methylator phenotype clear cell renal cell carcinomas2012

    • Author(s)
      Arai E, Chiku S, Mori T, Gotoh M, Nakagawa T, Fujimoto H, Kanai Y
    • Journal Title

      Carcinogenesis

      Volume: in print

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Functional genome survey of RCC.2011

    • Author(s)
      Ito H,Honda K,Satow R,Arai E,Shitashige M. et al.
    • Journal Title

      Jpn J Clin Oncol.

      Volume: 41 Issue: 7 Pages: 847-853

    • DOI

      10.1093/jjco/hyr060

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Copy number alterations in urothelial carcinomas : Their clinicopathological significance and correlation with DNA methylation alterations2011

    • Author(s)
      Nishiyama N, Inazawa J, et al
    • Journal Title

      Carcinogenesis

      Volume: 32 Issue: 4 Pages: 462-469

    • DOI

      10.1093/carcin/bgq274

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Diagnosis and prognostication of ductal adenocarcinomas of the pancreas based on genome-wide DNA methylation profiling by bacterial artificial chromosome array-based methylated CpG island amplification2011

    • Author(s)
      Gotoh M, Inazawa J, et al
    • Journal Title

      J Biomed Biotechnol

      Volume: 2011 Issue: 1 Pages: 780836-780836

    • DOI

      10.1155/2011/780836

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Carcinogenetic risk estimation based on quantification of DNA methylation levels in liver tissue at the precancerous stage2011

    • Author(s)
      Nagashio R, Kondo Y, 6名
    • Journal Title

      Int J Cancer

      Volume: 129 Issue: 5 Pages: 1170-1179

    • DOI

      10.1002/ijc.26061

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Genome-wide DNA methylation profiles in renal tumors of various histological subtypes and non-tumorous renal tissues2011

    • Author(s)
      Arai E, Inazawa J, et al
    • Journal Title

      Pathobiology

      Volume: 78 Issue: 1 Pages: 1-9

    • DOI

      10.1159/000322072

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Genetic and epigenetic alterations during renal carcinogenesis.2011

    • Author(s)
      Arai E, Kanai Y
    • Journal Title

      Int J Clin Exp Pathol

      Volume: 4 Pages: 58-73

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Presentation] DNA methylation profiles at precancerous stage cluster lung adenocarcinomas into subclusters associated with carcinogenetic pathway, clinicopathological aggressiveness and patient outcome2013

    • Author(s)
      Sato T, Arai E et al.
    • Organizer
      103rd American Association of Cancer Research Annual Meeting
    • Place of Presentation
      Washington D.C., USA
    • Year and Date
      2013-04-10
    • Related Report
      2012 Final Research Report
  • [Presentation] Multilayer-omics (whole-exome, methylome and transcriptome) analysis identifies the Wnt/β-catenin pathway as a key player in the development of renal cell carcinoma2013

    • Author(s)
      Arai E et al.
    • Organizer
      103rd American Association of Cancer Research Annual Meeting
    • Place of Presentation
      Washington D.C., USA
    • Year and Date
      2013-04-08
    • Related Report
      2012 Final Research Report
  • [Presentation] Single-CpG-resolution methylome analysis identifies clinicopathologically aggressive CpG island methylator phenotype clear cell renal cell carcinomas2013

    • Author(s)
      Arai E et al.
    • Organizer
      9th American Association of Cancer Research-Japanese Cancer Association Joint Conference
    • Place of Presentation
      Hawaii, USA
    • Year and Date
      2013-02-23
    • Related Report
      2012 Final Research Report
  • [Presentation] DNA methylation profiles at precancerous stage cluster lung adenocarcinomas into subclusters associated with carcinogenetic pathway, clinicopathological aggressiveness and patient outcome2013

    • Author(s)
      Sato T, Arai E et al.
    • Organizer
      9th American Association of Cancer Research-Japanese Cancer Association Joint Conference
    • Place of Presentation
      Hawaii, USA
    • Year and Date
      2013-02-23
    • Related Report
      2012 Final Research Report
  • [Presentation] 腎淡明細胞がんにおける多層的オミックス(エクソーム・メチローム・トランスクリプトーム)解析2012

    • Author(s)
      新井恵吏, 他
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Year and Date
      2012-09-21
    • Related Report
      2012 Final Research Report
  • [Presentation] 前がん段階におけるDNA メチル化異常が肺腺がんの悪性度と予後を規定する2012

    • Author(s)
      佐藤崇、新井恵吏, 他
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Year and Date
      2012-09-20
    • Related Report
      2012 Final Research Report
  • [Presentation] 尿路上皮がんにおけるゲノム構造異常:臨床病理学的意義ならびにDNA メチル化異常との関係2012

    • Author(s)
      西山直隆、新井恵吏, 他
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Year and Date
      2012-09-20
    • Related Report
      2012 Final Research Report
  • [Presentation] ゲノム網羅的DNA メチル化解析による腎淡明細胞がんのCpG アイランドメチル化形質2012

    • Author(s)
      新井恵吏, 他
    • Organizer
      日本エピジェネティクス研究会第6回年会
    • Place of Presentation
      東京
    • Year and Date
      2012-05-15
    • Related Report
      2012 Final Research Report
  • [Presentation] 肺多段階発がん過程におけるDNA メチル化異常のゲノム網羅的解析2012

    • Author(s)
      佐藤崇、新井恵吏, 他
    • Organizer
      日本エピジェネティクス研究会第6回年会
    • Place of Presentation
      東京
    • Year and Date
      2012-05-15
    • Related Report
      2012 Final Research Report
  • [Presentation] 肺多段階発がん過程におけるDNA メチル化の変化のゲノム網羅的解析2012

    • Author(s)
      佐藤崇、新井恵吏, 他
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      2012-04-27
    • Related Report
      2012 Final Research Report
  • [Presentation] 多層的オミックス解析による疾患の本態解明と臨床応用シンポジウム2「固形がんのエピゲノム解析」2012

    • Author(s)
      新井恵吏, 他
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      2012-04-27
    • Related Report
      2012 Final Research Report
  • [Presentation] 腎細胞がん発生過程におけるDNA メチル化異常の網羅的解析2011

    • Author(s)
      新井恵吏, 他
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-03
    • Related Report
      2012 Final Research Report
  • [Presentation] 腎細胞がん発生過程におけるDNA メチル化異常の網羅的解析2011

    • Author(s)
      新井恵吏, 他
    • Organizer
      日本エピジェネティクス研究会第5回年会
    • Place of Presentation
      熊本
    • Year and Date
      2011-05-20
    • Related Report
      2012 Final Research Report
  • [Presentation] 慢性障害肝におけるDNA メチル化状態を指標とした発がんリスク評価の肝生検検体を用いた臨床応用2011

    • Author(s)
      長塩亮、新井恵吏, 他
    • Organizer
      日本エピジェネティクス研究会第5回年会
    • Place of Presentation
      熊本
    • Year and Date
      2011-05-20
    • Related Report
      2012 Final Research Report
  • [Presentation] 酸化ストレス誘発ラット腎癌は高度な染色体不安定性を示す2011

    • Author(s)
      赤塚慎也、新井恵吏, 他
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2011-04-29
    • Related Report
      2012 Final Research Report 2011 Research-status Report
  • [Presentation] 泌尿器系腫瘍及びその背景組織のメチル化解析2011

    • Author(s)
      新井恵吏, 他
    • Organizer
      第100回日本病理学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2011-04-28
    • Related Report
      2012 Final Research Report 2011 Research-status Report
  • [Presentation] Copy number alterations in urothelial carcinomas: Their clinicopathological significance and correlation with DNA methylation alterations2011

    • Author(s)
      Nishiyama N, Arai E et al.
    • Organizer
      The 102nd Annual Meeting of AACR
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2011-04-02
    • Related Report
      2012 Final Research Report 2011 Research-status Report
  • [Presentation] 腎細胞がん発生過程におけるDNAメチル化異常の網羅的解析2011

    • Author(s)
      新井恵吏,森泰昌,知久季倫,後藤政広,中川徹,藤元博行,金井弥栄
    • Organizer
      第5回日本エピジェネティクス研究会年会
    • Place of Presentation
      熊本
    • Related Report
      2011 Research-status Report
  • [Presentation] 慢性障害肝におけるDNAメチル化状態を指標とした発がんリスク評価の肝生検検体を用いた臨床応用2011

    • Author(s)
      長塩亮,新井恵吏,尾島英知,小菅智男,金井弥栄
    • Organizer
      第5回日本エピジェネティクス研究会年会
    • Place of Presentation
      熊本
    • Related Report
      2011 Research-status Report
  • [Presentation] 腎細胞がん発生過程におけるDNAメチル化異常の網羅的解析2011

    • Author(s)
      新井恵吏,知久季倫,森泰昌,後藤政広,中川徹,藤元博行,金井弥栄
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Research-status Report
  • [Presentation] Multilayer-omics (whole-exome, methylome and transcriptome) analysis identifies the Wnt/β-catenin pathway as a key player in the development of renal cell carcinoma.

    • Author(s)
      Arai E et al.
    • Organizer
      103rd American Association of Cancer Research Annual Meeting
    • Place of Presentation
      Washington D.C. USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] DNA methylation profiles at precancerous stage cluster lung adenocarcinomas into subclusters associated with carcinogenetic pathway, clinicopathological aggressiveness and patient outcome.

    • Author(s)
      Sato T et al.
    • Organizer
      103rd American Association of Cancer Research Annual Meeting
    • Place of Presentation
      Washington D.C. USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Single-CpG-resolution methylome analysis identifies clinicopathologically aggressive CpG island methylator phenotype clear cell renal cell carcinomas.

    • Author(s)
      Arai E et al.
    • Organizer
      9th American Association of Cancer Research-Japanese Cancer Association Joint Conference
    • Place of Presentation
      Hawaii, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] DNA methylation profiles at precancerous stages associated with recurrence of lung adenocarcinoma.

    • Author(s)
      Sato T et al.
    • Organizer
      9th American Association of Cancer Research-Japanese Cancer Association Joint Conference
    • Place of Presentation
      Hawaii, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] 腎淡明細胞がんにおける多層的オミックス(エクソーム・メチローム・トランスクリプトーム)解析.

    • Author(s)
      新井恵吏 他
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report
  • [Presentation] 前がん段階におけるDNAメチル化異常が肺腺がんの悪性度と予後を規定する.

    • Author(s)
      佐藤崇 他
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report
  • [Presentation] 尿路上皮がんにおけるゲノム構造異常:臨床病理学的意義ならびにDNAメチル化異常との関係.

    • Author(s)
      西山直隆 他
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Annual Research Report
  • [Presentation] ゲノム網羅的DNAメチル化解析による腎淡明細胞がんのCpGアイランドメチル化形質

    • Author(s)
      新井恵吏 他
    • Organizer
      日本エピジェネティクス研究会第6回年会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 肺多段階発がん過程におけるDNAメチル化異常のゲノム網羅的解析

    • Author(s)
      佐藤崇 他
    • Organizer
      日本エピジェネティクス研究会第6回年会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 多層的オミックス解析による疾患の本態解明と臨床応用 シンポジウム2「固形がんのエピゲノム解析」

    • Author(s)
      新井恵吏
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 肺多段階発がん過程におけるDNAメチル化の変化のゲノム網羅的解析

    • Author(s)
      佐藤崇 他
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Book] DNA methylation alterations in human cancers. In: Epigenetics in Human Disease.2012

    • Author(s)
      Arai E et al.
    • Total Pages
      24
    • Publisher
      Elsevier
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Book] Epigenetics in Human Disease2011

    • Author(s)
      Kanai Y, Arai E.
    • Total Pages
      592
    • Publisher
      Academic Press
    • Related Report
      2012 Final Research Report
  • [Book] Academic Press2011

    • Author(s)
      Kanai Y, Arai E
    • Total Pages
      592
    • Publisher
      Epigenetics in Human Disease
    • Related Report
      2011 Research-status Report
  • [Remarks] ヒト多段階発がん過程におけるエピゲノム異常 : 国立がん研究センター研究所分子病理分野

    • URL

      http://www.ncc.go.jp/jp/nccri/divisions/01path/01path01.html

    • Related Report
      2012 Final Research Report
  • [Remarks] ヒト多段階発がん過程におけるエピゲノム異常:国立がん研究センター研究所分子病理分野

    • URL

      http://www.ncc.go.jp/jp/nccri/divisions/01path/01path01.html

    • Related Report
      2012 Annual Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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