| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Research Abstract |
This study has focused on the significance of epigenome alterations in multistage carcinogenesis associated with chronic inflammation. Genome-wide DNA methylation analysis was performed in cancerous and non-cancerous tissue samples obtained from patients with adenocarcinomas of the lung. For comparison, normal lung tissue samples from patients without any primary lung tumor were also analyzed. DNA methylation profiles, which may generate aggressive adenocarcinomas from the inflammatory background in chronic obstructive pulmonary disease in heavy smokers, were identified. Genome-wide DNA methylation analysis also identified DNA methylation profiles each specific to hepatocarcinogenesis associated with hepatitis B virus (HBV) infection and hepatitis C virus infection (HCV) and DNA methylation profiles shared by HBV-positive and HCV-positive patients.
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