| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Research Abstract |
It had been thought that nematodes are unable to synthesize heme, lacking all enzyme genes necessary for heme biosynthesis. However our analysis of Strongyloides (an animal parasitic nematode) genome and those of other nematode species indicated some animal parasitic nematode species possess genes that encode ferrochelatase (FeCH), an enzyme which medicates the terminal step of the heme biosynthesis.
Interestingly, nematode FeCH amino acid sequence showed more similarity to bacterial FeCH rather than to eukaryotic FeCH. Our results indicated some animal parasitic nematode species acquired FeCH gene from bacteria by horizontal gene transfer for a certain nutritional necessity at some point in their evolutionally histories.
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