Investigation of the role of antioxidant protein PrxI against tuberculosis
Project/Area Number |
23790466
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Bacteriology (including Mycology)
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Research Institution | Obihiro University of Agriculture and Veterinary Medicine |
Principal Investigator |
OKUMURA Kayo 帯広畜産大学, 畜産学部, 助教 (70415561)
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Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 細菌 / 感染症 / 結核 / マクロファージ |
Research Abstract |
To determine whether PrxI is essential for the host defense against tuberculosis, susceptibility of PrxI-deficient (PrxI KO) mice to Mycobacterium tuberculosis (Mtb) was compared to wild-type mice in vivo. We observed that PrxI KO mouse infected that with virulent Mtb survived significantly shorter as compared to the wild-type controls. Also we found that PrxI bound to Mtb specific protein.
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Report
(3 results)
Research Products
(16 results)
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[Presentation] 日本におけるヨーロッパ腐蛆病菌(Melissococcus plutonius)株の多様性とゲノム解析によるカリウム要求性に関与する遺伝子の同定.2011
Author(s)
荒井理恵, 奥村香世, 富永潔, 秋山徹, 大倉正稔, 切替照雄, 伊藤一智, 岡村直美, 大西英高, 大崎慎人, 高松大輔.
Organizer
第20回 Lancefieldレンサ球菌研究会
Place of Presentation
愛知学院大学, 愛知県
Related Report
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