| Project/Area Number |
23790471
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | National Institute of Infectious Diseases (2012)
The University of Tokyo (2011) |
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Principal Investigator |
OGAWA Michinaga 国立感染症研究所, 細菌第一部, 室長 (80361624)
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 感染免疫 / 赤痢菌 / オートファジー / 細胞死 / エフェクター / 細胞侵入菌 / 連鎖球菌 / Tecpr1 |
|---|
| Research Abstract |
We demonstrated that Tecpr1 is an essential component of the WIPI-2-Tecpr1- Atg5-dependent pathway in selective autophagy for Shigella, Salmonella, GAS, aggresomes, and damaged mitochondria. Next we revealed that Shigella deliver a caspase-4-specific inhibitor, OspC3, to antagonize epithelial cell death and promote infection.
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