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Analysis of the Shigella.Host defense interaction

Research Project

Project/Area Number 23790471
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Bacteriology (including Mycology)
Research InstitutionNational Institute of Infectious Diseases (2012)
The University of Tokyo (2011)

Principal Investigator

OGAWA Michinaga  国立感染症研究所, 細菌第一部, 室長 (80361624)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords感染免疫 / 赤痢菌 / オートファジー / 細胞死 / エフェクター / 細胞侵入菌 / 連鎖球菌 / Tecpr1
Research Abstract

We demonstrated that Tecpr1 is an essential component of the WIPI-2-Tecpr1- Atg5-dependent pathway in selective autophagy for Shigella, Salmonella, GAS, aggresomes, and damaged mitochondria. Next we revealed that Shigella deliver a caspase-4-specific inhibitor, OspC3, to antagonize epithelial cell death and promote infection.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (54 results)

All 2013 2012 2011 Other

All Journal Article (17 results) (of which Peer Reviewed: 13 results) Presentation (36 results) (of which Invited: 2 results) Remarks (1 results)

  • [Journal Article] The Shigella OspC3 effector inhibits Cspase-4, antagonizes inflammatory cell death, and promotes epithelial infection2013

    • Author(s)
      Kobayashi T, et. al
    • Journal Title

      Cell Host Microbe

      Volume: 13 Issue: 5 Pages: 570-583

    • DOI

      10.1016/j.chom.2013.04.012

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Shigella targets epithelial tricellular junctions to spread between cells via a noncanonical clathrin-dependent endocytic pathway.2012

    • Author(s)
      Makoto Fukumatsu
    • Journal Title

      Cell Host & Microbe

      Volume: 11 Issue: 4 Pages: 325-336

    • DOI

      10.1016/j.chom.2012.03.001

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Shigella flexneri effector OspI deamidates UBC13 to dampen the inflammatory response2012

    • Author(s)
      Sanada, T.
    • Journal Title

      Nature

      Volume: 483 Issue: 7391 Pages: 623-626

    • DOI

      10.1038/nature10894

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] A bacterial effector targets the TRAF6-NFκB pathway to modulate the acute inflammatory response to bacterial invasion of epithelial cells.2012

    • Author(s)
      Sanada T
    • Journal Title

      Virulence

      Volume: 3 Issue: 6 Pages: 518-21

    • DOI

      10.4161/viru.21451

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Uptake of Shigella-containing pseudopodia by neighboring epithelial cells at tricellular junctions via non-canonical clathrin-dependent trafficking pathway.2012

    • Author(s)
      Fukumatsu M
    • Journal Title

      Virulence

      Volume: 3 Issue: 6 Pages: 515-8

    • DOI

      10.4161/viru.21740

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Guideline for the use and interpretation of assays for monitoring autophagy2012

    • Author(s)
      Klionsky DJ,et al
    • Journal Title

      Autophagy

      Volume: 8 Issue: 4 Pages: 445-544

    • DOI

      10.4161/auto.19496

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 病原細菌を標的とした選択的オートファジーの分子メカニズム2012

    • Author(s)
      小川道永
    • Journal Title

      生物工学学会誌

      Volume: 90 Pages: 200-200

    • NAID

      110009445720

    • URL

      https://www.sbj.or.jp/wp-content/uploads/file/sbj/9004/9004_biomedia_4.pdf

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Journal Article] 病原細菌を標的としたオートファジーにおける新規認識機構2012

    • Author(s)
      小川道永
    • Journal Title

      化学と生物

      Volume: 50 Pages: 160-162

    • URL

      http://www.jsbba.or.jp/pub/journal_kasei/kasei_contents/vol50_3_2012.html

    • Related Report
      2012 Final Research Report 2011 Research-status Report
  • [Journal Article] 細胞侵入性細菌のオートファジーによる認識機構2012

    • Author(s)
      小川道永
    • Journal Title

      炎症と免疫

      Volume: 20 Pages: 151-156

    • Related Report
      2012 Final Research Report 2011 Research-status Report
  • [Journal Article] A tecpr1-dependent selective autophagy pathway targets bacterial pathogens2011

    • Author(s)
      Kawalec M, Reichhart JM, Sasakawa C
    • Journal Title

      Cell Host Microbe

      Volume: 9 Issue: 5 Pages: 376-389

    • DOI

      10.1016/j.chom.2011.04.010

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Autophagy targeting of Listeria monocytogenes and the bacterial countermeasure.2011

    • Author(s)
      Ogawa, M., Yoshikawa, Y., Mimuro, H., Hain, T., Chakraborty, T. & Sasakawa, C
    • Journal Title

      Autophagy

      Volume: 7 Issue: 3 Pages: 310-314

    • DOI

      10.4161/auto.7.3.14581

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Manipulation of autophagy by bacteria for their own benefit2011

    • Author(s)
      Ogawa M.
    • Journal Title

      Microbiology and Immunology

      Volume: VOL.55 Issue: 7 Pages: 459-471

    • DOI

      10.1111/j.1348-0421.2011.00343.x

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] The role of Tecpr1 in selective autophagy as a cargo receptor.2011

    • Author(s)
      Ogawa, M. & Sasakawa, C
    • Journal Title

      Autophagy

      Volume: 7 Issue: 11 Pages: 1389-91

    • DOI

      10.4161/auto.7.11.17151

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Bacteria and host interactions in the gut epithelial barrier2011

    • Author(s)
      Ashida H., Sasakawa C., et al.
    • Journal Title

      Nat Chem Biol

      Volume: 8 Issue: 1 Pages: 36-45

    • DOI

      10.1038/nchembio.741

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cell death and infection : a double-edged sword for host and pathogen survival2011

    • Author(s)
      Ashida H, Mimuro H, Ogawa M, Kobayashi T, Sanada T, Kim M, Sasakawa C
    • Journal Title

      J Cell Biol

      Volume: 195 Issue: 6 Pages: 931-942

    • DOI

      10.1083/jcb.201108081

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Shigella are versatile mucosal pathogens that circumvent the host innate immune system2011

    • Author(s)
      Ashida H, Ogawa M, Mimuro H, Kobayashi T, Sanada T, Sasakawa C
    • Journal Title

      Curr Opin Immunol

      Volume: 23 Issue: 4 Pages: 448-455

    • DOI

      10.1016/j.coi.2011.06.001

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 赤痢菌の自然免疫回避機構2011

    • Author(s)
      小川道永、笹川千尋
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 56 Pages: 600-608

    • NAID

      40019087260

    • URL

      http://www.kahyo.com/item/M201111-565

    • Related Report
      2012 Final Research Report 2011 Research-status Report
  • [Presentation] 赤痢菌の感染戦略~宿主細胞の感染性細胞死に抗うカスパーゼ阻害エフェクター~2013

    • Author(s)
      小林泰良,小川道永,真田貴人,三室仁美,笹川千尋
    • Organizer
      第86回日本細菌学会総会
    • Place of Presentation
      千葉(幕張)
    • Year and Date
      2013-03-19
    • Related Report
      2012 Final Research Report
  • [Presentation] Tecpr1 による選択的オートファジー認識機構2013

    • Author(s)
      小川道永
    • Organizer
      第86回日本細菌学会総会
    • Place of Presentation
      千葉(幕張)
    • Year and Date
      2013-03-18
    • Related Report
      2012 Final Research Report
  • [Presentation] 病原細菌と宿主との攻防~感染生物学のススメ~2012

    • Author(s)
      小川道永
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2012-12-13
    • Related Report
      2012 Final Research Report
  • [Presentation] 赤痢菌の感染戦略~宿主細胞の炎症性細胞死に抗うカスパーゼ阻害エフェクター~2012

    • Author(s)
      小林泰良,小川道永,三室仁美,笹川千尋
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2012-12-13
    • Related Report
      2012 Final Research Report
  • [Presentation] 赤痢菌III型分泌OspIによる炎症抑制機構の新規メカニズムの解明2012

    • Author(s)
      真田貴人、KimMinsoo、三室仁美、鈴木仁人、小川道永、小山晃穂、芦田浩、小林泰良、小山智洋、長井伸也、柴田佑里、合田仁、井上純一郎、水島恒裕、笹川千尋
    • Organizer
      第95回日本細菌学会関東支部総会
    • Place of Presentation
      東京(お台場)
    • Year and Date
      2012-10-11
    • Related Report
      2012 Final Research Report
  • [Presentation] 赤痢菌の上皮細胞内生存戦略としてのパイロプトーシス抑制機構2012

    • Author(s)
      小林泰良、小川道永、三室仁美、笹川千尋
    • Organizer
      第95回日本細菌学会関東支部総会
    • Place of Presentation
      東京(お台場)
    • Year and Date
      2012-10-11
    • Related Report
      2012 Final Research Report
  • [Presentation] A bacterial effector hijacks a novel Caspase-4 dependent epithelial cell death pathway2012

    • Author(s)
      小林泰良、小川道永、笹川千尋
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎
    • Year and Date
      2012-03-28
    • Related Report
      2012 Final Research Report
  • [Presentation] A bacterial effector deamidates Ubc13 to dampen the inflammatory response2012

    • Author(s)
      真田貴人、キムミンス、三室仁美、鈴木仁人、小山明穂、芦田浩、小川道永、井上純一郎、水島恒裕、笹川千尋
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎
    • Year and Date
      2012-03-28
    • Related Report
      2012 Final Research Report
  • [Presentation] Intercellular spreading of Shigella flexneri in mammalian cells2012

    • Author(s)
      福松真、小川道永、三室仁美、笹川千尋
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎
    • Year and Date
      2012-03-28
    • Related Report
      2012 Final Research Report
  • [Presentation] Tecpr1 in Shigella-selective autophagy2012

    • Author(s)
      小川道永、笹川千尋
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎
    • Year and Date
      2012-03-27
    • Related Report
      2012 Final Research Report
  • [Presentation] Selective autophagy for intracellular bacteria2012

    • Author(s)
      小川道永
    • Organizer
      11th Korea-Japan International Symposium on Microbiology (XI-KJISM)
    • Place of Presentation
      Buyeo, Korea
    • Related Report
      2012 Final Research Report
  • [Presentation] Selective autophagy for intracellular bacteria2012

    • Author(s)
      小川道永
    • Organizer
      11th Korea-Japan International Symposium on Microbiology
    • Place of Presentation
      韓国・ブヨ
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Tecpr1 in Shigella-selective autophagy2012

    • Author(s)
      小川道永、笹川千尋
    • Organizer
      第85回日本細菌学会
    • Place of Presentation
      長崎
    • Related Report
      2011 Research-status Report
  • [Presentation] A bacterial effector hijacks a novel Caspase-4 dependent epithelial cell death pathway2012

    • Author(s)
      小林泰良、小川道永、笹川千尋
    • Organizer
      第85回日本細菌学会
    • Place of Presentation
      長崎
    • Related Report
      2011 Research-status Report
  • [Presentation] A bacterial effector deamidates Ubc13 to dampen the inflammatory response2012

    • Author(s)
      真田貴人、キムミンス、三室仁美、鈴木仁人、小山明穂、芦田浩、小川道永、井上純一郎、水島恒裕、笹川千尋
    • Organizer
      第85回日本細菌学会
    • Place of Presentation
      長崎
    • Related Report
      2011 Research-status Report
  • [Presentation] Intercellular spreading of Shigella flexneri in mammalian cells2012

    • Author(s)
      福松真、小川道永、三室仁美、笹川千尋
    • Organizer
      第85回日本細菌学会
    • Place of Presentation
      長崎
    • Related Report
      2011 Research-status Report
  • [Presentation] Autophagy and bacterial infection2011

    • Author(s)
      小川道永
    • Organizer
      2^<nd> International symposium, Microbes For Health
    • Place of Presentation
      パリ
    • Year and Date
      2011-12-01
    • Related Report
      2012 Final Research Report
  • [Presentation] 病原細菌としたオートファジー認識機構と病原細菌によるその回避機構2011

    • Author(s)
      小川道永
    • Organizer
      第94回細菌学会関東支部総会
    • Place of Presentation
      東京
    • Year and Date
      2011-10-07
    • Related Report
      2012 Final Research Report
  • [Presentation] 赤痢菌のタイプIIIエフェクターによるパイロプトーシス回避機構2011

    • Author(s)
      小林泰良、小川道永、笹川千尋
    • Organizer
      第94回細菌学会関東支部総会
    • Place of Presentation
      東京
    • Year and Date
      2011-10-06
    • Related Report
      2012 Final Research Report 2011 Research-status Report
  • [Presentation] 赤痢菌における細胞間拡散機構2011

    • Author(s)
      福松真、小川道永、三室仁美、笹川千尋
    • Organizer
      第94回細菌学会関東支部総会
    • Place of Presentation
      東京
    • Year and Date
      2011-10-06
    • Related Report
      2012 Final Research Report 2011 Research-status Report
  • [Presentation] Shigella flexneri hijack Caspse-4 to evade Pyroptosis2011

    • Author(s)
      小林泰良、小川道永、笹川千尋
    • Organizer
      IMSUT/RCAST . Chiba University Global COE Joint Retreat 2011
    • Place of Presentation
      大磯
    • Year and Date
      2011-09-17
    • Related Report
      2012 Final Research Report
  • [Presentation] Intercellular spreading of Shigella flexneri in mammalian cells2011

    • Author(s)
      福松真、小川道永、三室仁美、笹川千尋
    • Organizer
      IMSUT/RCAST . Chiba University Global COE Joint Retreat 2011
    • Place of Presentation
      大磯
    • Year and Date
      2011-09-17
    • Related Report
      2012 Final Research Report
  • [Presentation] Autophagy and bacterial infection2011

    • Author(s)
      小川道永
    • Organizer
      IUMS2011
    • Place of Presentation
      札幌
    • Year and Date
      2011-09-08
    • Related Report
      2012 Final Research Report
  • [Presentation] The role of Tecpr1-depedent Selective autophagic pathway in targeting bacterial pathogens2011

    • Author(s)
      小川道永、笹川千尋
    • Organizer
      IUMS2011
    • Place of Presentation
      札幌
    • Year and Date
      2011-09-08
    • Related Report
      2012 Final Research Report 2011 Research-status Report
  • [Presentation] Intercellular spreading of Shigella flexneri in mammalian cells2011

    • Author(s)
      福松真、小川道永、鈴木仁人、三室仁美、笹川千尋
    • Organizer
      IUMS2011
    • Place of Presentation
      札幌
    • Year and Date
      2011-09-08
    • Related Report
      2012 Final Research Report 2011 Research-status Report
  • [Presentation] Shigella flexneri hijack Caspse-4 to evade Pyroptosis2011

    • Author(s)
      小林泰良、小川道永、笹川千尋
    • Organizer
      IMSUT/RCAST-Chiba University Global COE Joint Retreat 2011
    • Place of Presentation
      大磯
    • Related Report
      2011 Research-status Report
  • [Presentation] Intercellular spreading of Shigella flexneri in mammalian cells2011

    • Author(s)
      福松真、小川道永、三室仁美、笹川千尋
    • Organizer
      IMSUT/RCAST-Chiba University Global COE Joint Retreat 2011
    • Place of Presentation
      大磯
    • Related Report
      2011 Research-status Report
  • [Presentation] Autophagy and bacterial infection2011

    • Author(s)
      小川道永
    • Organizer
      2nd International symposium, Microbes For Health(招待講演)
    • Place of Presentation
      パリ, フランス
    • Related Report
      2011 Research-status Report
  • [Presentation] 病原細菌を標的としたオートファジー認識機構と病原細菌によるその回避機構2011

    • Author(s)
      小川道永
    • Organizer
      第94回細菌学会関東支部総会(招待講演)
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] Autophagy and bacterial infection2011

    • Author(s)
      小川道永
    • Organizer
      IUMS2011(招待講演)
    • Place of Presentation
      札幌
    • Related Report
      2011 Research-status Report
  • [Presentation] 病原細菌と宿主との攻防 ~感染生物学のススメ~

    • Author(s)
      小川道永
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Tecpr1による選択的オートファジー認識機構

    • Author(s)
      小川道永
    • Organizer
      第86回日本細菌学会総会
    • Place of Presentation
      幕張メッセ
    • Related Report
      2012 Annual Research Report
  • [Presentation] 赤痢菌の感染戦略~宿主細胞の感染性細胞死に抗うカスパーゼ阻害エフェクター~

    • Author(s)
      小林泰良,小川道永,真田貴人,三室仁美,笹川千尋
    • Organizer
      第86回日本細菌学会総会
    • Place of Presentation
      幕張メッセ
    • Related Report
      2012 Annual Research Report
  • [Presentation] 赤痢菌の感染戦略 ~宿主細胞の炎症性細胞死に抗うカスパーゼ阻害エフェクター~

    • Author(s)
      小林泰良,小川道永,三室仁美,笹川千尋
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] 赤痢菌 III 型分泌 OspI による炎症抑制機構の新規メカニズムの解明

    • Author(s)
      真田貴人 、Kim Minsoo、三室仁美、鈴木仁人、小川道永、小山晃穂、芦田浩、小林泰良、小山智洋、長井伸也、柴田佑里、合田仁、井上純一郎、水島恒裕、笹川千尋
    • Organizer
      第95回日本細菌学会関東支部総会
    • Place of Presentation
      東京・お台場
    • Related Report
      2012 Annual Research Report
  • [Presentation] 小林泰良、小川道永、三室仁美、笹川千尋

    • Author(s)
      赤痢菌の上皮細胞内生存戦略としてのパイロプトーシス抑制機構
    • Organizer
      第95回日本細菌学会関東支部総会
    • Place of Presentation
      東京・お台場
    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://first.lifesciencedb.jp/archives/2966

    • Related Report
      2012 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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