| Project/Area Number |
23790477
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | University of Miyazaki |
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Principal Investigator |
IGUCHI Atsushi 宮崎大学, IR 推進機構, 助教 (00437948)
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| Co-Investigator(Renkei-kenkyūsha) |
IYODA Sunao 国立感染症研究所, 細菌第一部, 主任研究官 (70300928)
OHNISHI Makoto 国立感染症研究所, 細菌第一部, 部長 (10233214)
SETO Kazuko 大阪府立公衆衛生研究所, 細菌課, 主任研究員 (70211323)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 分類 / 腸管出血性大腸菌 / O血清群 |
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| Research Abstract |
We investigated the O-antigen biosynthsis gene (O-Ag) clusters from enterohemorrhagic E. coli (EHEC) O serogroup-untypeable (OUT) strains isolated inJapan. Comparative analysis of O-Ag cluster sequences from EHEC OUT strains identifiedthat at least four O-Ag clusters were novel. T o evaluate the prevalence of the novel EHECO-serogroup, strains were screened by using the genetic method developed in this study ,suggesting that a novel EHEC O serogroup (OSB10=O183) was widespread in Japan andassociated with diarrhea and hemorrhagic colitis. T o gain more information about trends inEHEC OUT epidemiology , further studies of global OUT isolates are needed, and thePCR-based methodologies developed in this study may help the surveillance andmonitoring of the EHEC OUT
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