Characterization of bacterial collagen sensor and adhesin for screening of new matrix anchors
| Project/Area Number |
23790483
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Okayama University (2012-2013)
Kitasato University (2011) |
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Principal Investigator |
MIMA Takehiko 岡山大学, 医歯(薬)学総合研究科, 助教 (80596437)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | コラゲナーゼ / ビブリオ / 発現調節 / 二成分制御系 / 遺伝子発現 / 毒素 / Two-component system / Vibrio / V. alginolyticus / 発現誘導 / コラーゲン / マトリックス・アンカー / alginolyticus |
|---|
| Research Abstract |
Vibrio alginolyticus produces collagenase only when collagen is present. This shows that V. alginolyticus possesses the sensor for collagen. Isolating mutants that are deficient in collagenase production using newly invented method identified genes that regulate production of collagenase in V. alginolyticus. As the result, two-component regulatory system was identified to regulate the expression of collagenase in V. alginolyticus.
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Report
(4 results)
Research Products
(38 results)
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[Presentation] Differential targeting mechanism of prototypical collagen binding domains from clostridial collagenase2013
Author(s)
Joshua Sakon, Keisuke Tanaka, Rohana Liyanage, Jackson O. Lay, Jr, Ryan Bauer, Takehiko Mima, Shunji Hattori, Osamu Matsushita
Organizer
Gordon Research Conferences
Place of Presentation
New London, NH, USA
Related Report
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[Presentation] Identification of binding sequence on porcine type I collagen by collagen-binding domain from Clostridial collagenase ColG2013
Author(s)
Keisuke Tanaka, Rohana Liyanage, Jackson O. Lay, Jr, Ryan Bauer, Takehiko Mima, Shunji Hattori, Osamu Matsushita, Joshua Sakon
Organizer
Gordon Research Conferences
Place of Presentation
New London, NH, USA
Related Report
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