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Molecular mechanisms for necrosis induced by BordetellaBopC

Research Project

Project/Area Number 23790484
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Bacteriology (including Mycology)
Research InstitutionKitasato University

Principal Investigator

KUWAE Asaomi  北里大学, 大学院・感染制御科学府, 講師 (60337996)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsボルデテラ属細菌 / エフェクター / III型分泌装置 / ボルデテラ / BopC / 百日咳 / 病原因子
Research Abstract

I analyzed how BopC, which is the protein secreted from Bordetella, cause necrosis to mammalian cells. When mammalian cells were infected with Bordetella, the cells shrank and then spread before celldeath. Moreover, protein kinase C inhibitor specifically suppressed cell death induced by BopC function.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (15 results)

All 2013 2012 Other

All Presentation (12 results) (of which Invited: 1 results) Remarks (3 results)

  • [Presentation] Bordetellaimmune evasion by type III effectors2013

    • Author(s)
      桑江朝臣
    • Organizer
      第155回日本獣医学会学術集会
    • Place of Presentation
      東京大学駒場キャンパス
    • Year and Date
      2013-03-29
    • Related Report
      2012 Final Research Report
  • [Presentation] ボルデテラ感染におけるBopCの機能2013

    • Author(s)
      桑江朝臣
    • Organizer
      第86回日本細菌学会総会
    • Place of Presentation
      幕張メッセ
    • Related Report
      2012 Final Research Report
  • [Presentation] ボルデテラ感染におけるBopCの機能2013

    • Author(s)
      桑江朝臣
    • Organizer
      第86回 日本細菌学会総会
    • Place of Presentation
      幕張メッセ
    • Related Report
      2012 Annual Research Report
  • [Presentation] Bordetella immune evasion by type III effectors2013

    • Author(s)
      桑江朝臣
    • Organizer
      第155回 日本獣医学会学術集会
    • Place of Presentation
      東京大学駒場キャンパス
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Bordetellablocks phagocytosis and alters host cell signaling through BopC/BteA, a type III effector2012

    • Author(s)
      桑江朝臣
    • Organizer
      The 34th Naito Conference on Infection, Immunity and their Control for Health: Mucosal Barrier, Pathogen and Vaccine
    • Place of Presentation
      シャトレーゼガトーキングダム札幌
    • Year and Date
      2012-10-17
    • Related Report
      2012 Final Research Report
  • [Presentation] Bordetellablocks phagocytosis and alters host cell signaling through BopC/BteA, a type III effector2012

    • Author(s)
      桑江朝臣
    • Organizer
      The 11th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      ウェスティンホテル淡路島
    • Year and Date
      2012-09-13
    • Related Report
      2012 Final Research Report
  • [Presentation] ボルデテラ属細菌のBopCは貪食運動を阻害する2012

    • Author(s)
      桑江朝臣
    • Organizer
      第6回細菌学・若手コロッセウム
    • Place of Presentation
      八王子セミナーハウス
    • Year and Date
      2012-08-08
    • Related Report
      2012 Final Research Report
  • [Presentation] ボルデテラ属細菌のBopCは貪食運動を阻害する2012

    • Author(s)
      桑江朝臣
    • Organizer
      第6回 細菌学・若手コロッセウム
    • Place of Presentation
      八王子セミナーハウス
    • Related Report
      2012 Annual Research Report
  • [Presentation] Bordetella blocks phagocytosis and alters host cell signaling through BopC/BteA, a type III effector2012

    • Author(s)
      桑江朝臣
    • Organizer
      The 11th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      ウェスティンホテル淡路島
    • Related Report
      2012 Annual Research Report
  • [Presentation] Bordetella blocks phagocytosis and alters host cell signaling through BopC/BteA, a type III effector2012

    • Author(s)
      桑江朝臣
    • Organizer
      The 34th Naito Conference on Infection, Immunity and their Control for Health: Mucosal Barrier, Pathogen and Vaccine
    • Place of Presentation
      シャトレーゼガトーキングダム札幌
    • Related Report
      2012 Annual Research Report
  • [Presentation] Bordetella blocks phagocytosis and alters host cell signaling through BopC/BteA, a type III effector

    • Author(s)
      Asaomi Kuwae, Kanna Nagamatsu, Akio Abe
    • Organizer
      International Union of Microbiological Societies IUMS
    • Place of Presentation
      札幌
    • Related Report
      2011 Research-status Report
  • [Presentation] BopC functions in Bordetella infection

    • Author(s)
      Asaomi Kuwae
    • Organizer
      第85回 日本細菌学会総会(招待講演)
    • Place of Presentation
      長崎
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://www.kitasato-u.ac.jp/lisci/life/chart/LSI-lab13.html

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.lisci.kitasato-u.ac.jp:8080/bact_infect/Site/Welcome.html

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.lisci.kitasato-u.ac.jp:8080/bact_infect/Site/Publications.html

    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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