Molecular mechanisms for necrosis induced by BordetellaBopC
| Project/Area Number |
23790484
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Kitasato University |
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Principal Investigator |
KUWAE Asaomi 北里大学, 大学院・感染制御科学府, 講師 (60337996)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ボルデテラ属細菌 / エフェクター / III型分泌装置 / ボルデテラ / BopC / 百日咳 / 病原因子 |
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| Research Abstract |
I analyzed how BopC, which is the protein secreted from Bordetella, cause necrosis to mammalian cells. When mammalian cells were infected with Bordetella, the cells shrank and then spread before celldeath. Moreover, protein kinase C inhibitor specifically suppressed cell death induced by BopC function.
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Report
(3 results)
Research Products
(15 results)
