Research Project
Grant-in-Aid for Young Scientists (B)
Influenza C virus CM2 protein is involved in genome packaging and uncoating. To clarify the domains of CM2 participating in these functions, we introduced a series of deletion and substitution mutations in the CM2 cytoplasmic tail. We analyzed these mutants and obtained the following results.1. C-terminal 53 amino acids of CM2 protein are not essential for its transport to the cell surface.2. The specific amino acid sequence of cytoplasmic tail of CM2 is required for its intracellular transport.3. The cytoplasmic tail is required for stable oligomerization (formation of a dimer and a tetramer).
All 2012 2011
All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (11 results)
J. Clin. Virol.
Volume: 54 Issue: 2 Pages: 130-134
10.1016/j.jcv.2012.02.012
Current Topics in Virology
Volume: 9 Pages: 69-77
