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The pathogenic mechanism of HTLV-1 leukemogenesis via novel binding protein of Tax1

Research Project

Project/Area Number 23790498
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Virology
Research InstitutionNiigata University

Principal Investigator

TAKAHASHI Masahiko  新潟大学, 医歯学系, 助教 (80377192)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsHTLV-1 / Tax1 / USP10 / ストレス顆粒 / 活性酸素種 / ROS / G3BP1
Research Abstract

We examined functional roles of USP10 and its binding partner G3BP1. We found that G3BP1 elevates the steady-state ROS level by inhibiting the antioxidant activity of USP10. However, following exposure to arsenic, G3BP1 and USP10 induce the formation of stress granules, which uncovers the antioxidant activity of USP10. We also found that the antioxidant activity of USP10 requires the protein kinase activity of ATM.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (8 results)

All 2013 2012 2011 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (3 results)

  • [Journal Article] Stress granules inhibit apoptosis by reducing reactive oxygen species production.2013

    • Author(s)
      Masahiko Takahashi
    • Journal Title

      Molecular and Cellular Biology

      Volume: 33 Issue: 4 Pages: 815-829

    • DOI

      10.1128/mcb.00763-12

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Both G3BP1 and G3BP2 contribute to stress granule formation.2013

    • Author(s)
      Hideaki Matsuki
    • Journal Title

      Genes to Cells

      Volume: 18 Issue: 2 Pages: 135-146

    • DOI

      10.1111/gtc.12023

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Human T cell leukemia virus type 2 (HTLV-2) Tax2 has a dominant activity over HTLV-1 Tax1 to immortalize human CD4+ T cells.2013

    • Author(s)
      Michitaka Imai
    • Journal Title

      Virus Genes

      Volume: 46 Issue: 1 Pages: 39-46

    • DOI

      10.1007/s11262-012-0831-9

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Human T-cell leukemia virus type 1 Tax protein interacts with and mislocalizes the PDZ domain protein MAGI-12013

    • Author(s)
      Grace Naswa Makokha
    • Journal Title

      Cancer Science

      Volume: 104 Issue: 3 Pages: 313-320

    • DOI

      10.1111/cas.12087

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of mTOR by human T-cell leukemia virus type 1 Tax is important for the transformation of mouse T cells to interleukin-2-independent growth2011

    • Author(s)
      Manami Yoshita
    • Journal Title

      Cancer Science

      Volume: 103巻 Issue: 2 Pages: 369-374

    • DOI

      10.1111/j.1349-7006.2011.02123.x

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] Stress granules inhibit apoptosis by reducing ROS production, and this is nullified by HTLV-1 Tax12012

    • Author(s)
      高橋雅彦
    • Organizer
      第71回日本癌学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2012-09-19
    • Related Report
      2012 Final Research Report
  • [Presentation] USP10は亜ヒ酸によるHTLV-1感染細胞のアポトーシス感受性に関与する2012

    • Author(s)
      高橋雅彦
    • Organizer
      第5回HTLV研究会およびシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2012-08-25
    • Related Report
      2012 Final Research Report
  • [Presentation] ストレス顆粒はROS産生を抑制することによりアポトーシスを阻害するが、これをHTLV-1のTax1は解除する

    • Author(s)
      高橋 雅彦
    • Organizer
      日本癌学会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Related Report
      2012 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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