Role of inhibitory activity of paramyxoviruses against host alpha-interferon production in virus pathogenicity
| Project/Area Number |
23790499
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Virology
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | パラミクソウイルス / IFNアンタゴニスト / アクセサリー蛋白質 / 自然免疫 / インターフェロン / TLR-7/9経路 |
|---|
| Research Abstract |
Paramyxovirus V proteins block Toll-like receptor 7 (TLR7)- and TLR9-dependent signaling leading to alpha interferon production. However, the detailed mechanisms remain unclear. Here we revealed that the human parainfluenza virus type 2 (HPIV2) V protein interacted with TRAF6 and inhibited not only TRAF6-mediated lysine 63 (K63)-linked polyubiquitination but also subsequent phosphorylation of IRF7. These results suggest that the HPIV2 V protein prevents TRL7/9-dependent interferon induction by inhibiting TRAF6-mediated K63-linked polyubiquitination of IRF7.
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Report
(4 results)
Research Products
(25 results)
