Mechanistic analysis about the association of IL28B genetic polymorphism with IFN sensitivity in HCV infected patients
| Project/Area Number |
23790502
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Virology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | C型肝炎ウイルス / 肝臓移植 / IL28B / IFN感受性 |
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| Research Abstract |
In this study, we evaluated the importance of IL28B genetic polymorphism in IFN sensitivity for recurrent hepatitis C after liver transplantation. Interestingly, genetic variability in both recipients and donors was significantly associated with IFN sensitivity, suggesting crosstalk between lymphocyte and HCV-infected hepatocyte participates in the IFN sensitivity. In addition, we established allele-specific IL28B knockout Huh7 cells by using chimeric nucleases.
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Report
(3 results)
Research Products
(27 results)
