Non-enveloped virus release by intracellular membrane trafficking
Project/Area Number |
23790503
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Virology
|
Research Institution | Osaka University |
Principal Investigator |
MORITA Eiji 大阪大学, 微生物病研究所, 特任准教授 (70344653)
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | 細胞 / メンブレントラフィック / ウイルス / オートファジー |
Research Abstract |
In this study, we identified that dominant negative expression or gene disruption of autophagy (ATG) genes negatively regulates the viral like particle production from the cells. We also confirmed that several viral protein positive compartments are co-localizes with LC3s, markers for autophagosome. These results suggest that the cellular autophagy pathway are involved in the virus particle release in infected cells.
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Report
(3 results)
Research Products
(12 results)