| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Research Abstract |
In this study, we identified that dominant negative expression or gene disruption of autophagy (ATG) genes negatively regulates the viral like particle production from the cells. We also confirmed that several viral protein positive compartments are co-localizes with LC3s, markers for autophagosome. These results suggest that the cellular autophagy pathway are involved in the virus particle release in infected cells.
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