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Analysis of the newly identified receptor during VZV entry into hematopoietic cells

Research Project

Project/Area Number 23790504
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Virology
Research InstitutionOsaka University

Principal Investigator

SUENAGA Tadahiro  大阪大学, 微生物病研究所, 助教 (20396675)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords水痘帯状疱疹ウイルス / 膜融合 / エントリー / グリコプロテインB(gB) / グリコプロテインB (gB)
Research Abstract

We have previously reported that myelin-associated glycoprotein (MAG) expressed limitedly in neural tissues is an entry receptor of varicella-zoster virus (VZV). Blood cells are also known as a gate for VZV to infect the host. The purpose of this study is to identify the VZV entry receptor on blood cells and to analyze the mechanism of VZV entry mediated by the newly identified receptor. We found that homologous molecule to MAG, VgBR2, expressed on blood cells binds to VZV glycoprotein B (gB). The association of gB not only with MAG but also with VgBR2 induces fusion between viral envelope and host cell membrane and permits VZV to enter into host blood cells (Suenaga et. al. manuscript in preparation). We also found that glycosylation on gB is involved in VZV infection mediated by MAG and VgBR2. We identified glycosylation sites and glycosylation styles on gB required for fusion mediated by MAG (Suenaga et. al. manuscript in preparation).

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (36 results)

All 2014 2013 2012 2011 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (29 results) Remarks (4 results)

  • [Journal Article] Autoantibodies to IgG/HLA class II complexes are associated with rheumatoid arthritis susceptibility2014

    • Author(s)
      Jin H, Arase N, Hirayasu K, Kohyama M, Suenaga T, Saito F, Tanimura K, Matsuoka S, Ebina K, Shi K, Toyama-Sorimachi N, Yasuda S, Horita T, Hiwa R, Takasugi K, Ohmura K, Yoshikawa H, Saito T, Atsumi T, Sasazuki T, Katayama I, Lanier LL, Arase H
    • Journal Title

      Proceedings of National Academy of Science USA

      Volume: 111 Issue: 10 Pages: 3787-3792

    • DOI

      10.1073/pnas.1401105111

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Herpesvirus 6 glycoproteins B (gB), gH, gL, and gQ are necessary and sufficient for cell-to-cell fusion.2013

    • Author(s)
      Tanaka Y, Suenaga T, Matsumoto M, Seya T, Arase H.
    • Journal Title

      J Virol.

      Volume: 87(19) Issue: 19 Pages: 10900-10903

    • DOI

      10.1128/jvi.01427-13

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transport of misfolded endoplasmic reticulum proteins to the cell surface by MHC class II molecules.2013

    • Author(s)
      Jiang, Y., Arase, N., Kohyama, M., Hirayasu, K., Suenaga, T., Jin, H., Matsumoto, M., Shida, K., L. Lanier, L., Saito, T. and Arase, H.
    • Journal Title

      Int. Immunol.

      Volume: 25 Issue: 4 Pages: 235-246

    • DOI

      10.1093/intimm/dxs155

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Rheumatoid factor binding to IgG heavy chain presented on HLA-DR is associated with Rheumatoid Arthritis susceptibility2013

    • Author(s)
      Jin Hui,Arase Noriko,Kohayama Masako,Saito Fumiji,Hirayasu Kouyuki,Matsumoto Maki,Shida Kyoko,Suenaga Tadahiro,Saito Takashi,Katayama Ichiro,Lanier Lewis L.,Arase Hisashi
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉市)
    • Year and Date
      2013-12-13
    • Related Report
      2013 Final Research Report
  • [Presentation] 2-glycoprotein I presented on MHC class II molecules are recognized by autoantibodies in antiphospholipid syndrome2013

    • Author(s)
      Tanimura Kenji,Suenaga Tadahiro,Jin Hui,Hirayasu Kouyuki,Arase Noriko,Kohayama Masako,Ebina Yasuhiko,Yasuda Shinsuke,Horita Tetsuya,Katayama Ichiro,Atsumi Tatsuya,Yamada Hideo,Arase Hisashi
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉市)
    • Year and Date
      2013-12-13
    • Related Report
      2013 Final Research Report
  • [Presentation] PILRαnegatively regulates DSS induced experimental colitis2013

    • Author(s)
      Kishida Kazuki,Kohyama Masako,Kurashima Yosuke,Wang Jing,Hirayasu Kouyuki,Suenaga Tadahiro,Kiyono Hiroshi,Kunisawa Jun,Arase Hisashi
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉市)
    • Year and Date
      2013-12-13
    • Related Report
      2013 Final Research Report
  • [Presentation] 水痘帯状庖疹ウイルス(VzV)の膜融合メカニズムの解析2013

    • Author(s)
      末永忠広、森康子、荒瀬尚
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Year and Date
      2013-11-10
    • Related Report
      2013 Final Research Report
  • [Presentation] Herpesvirus 6 Glycoprotein B (gB),gH,gL and gQ are Necessary and Sufficient for Cell-to-Cell Fusion2013

    • Author(s)
      Tadahiro Suenaga,Yuki Tanaka,Misako Matsumoto,Tsukasa Seya,Hisashi Arase
    • Organizer
      38th International Herpesvirus Workshop
    • Place of Presentation
      Grand Rapids,Michigan (USA)
    • Year and Date
      2013-07-21
    • Related Report
      2013 Final Research Report
  • [Presentation] 水痘帯状庖疹ウイルス(VzV)glycoprotein H (gH)受容体の解析2013

    • Author(s)
      末永忠広、松本麻紀、有津史倫、森康子、荒瀬尚
    • Organizer
      第28回ヘルペスウイルス研究会
    • Place of Presentation
      淡路夢舞台国際会議場(淡路市)
    • Year and Date
      2013-05-31
    • Related Report
      2013 Final Research Report
  • [Presentation] Human cytomegalovirus UL10 regulates immune response via inhibitory PILRα2012

    • Author(s)
      Fuminori Arisawa,Jing Wang,Tadahiro Suenaga,Hisashi Arase
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸国際会議場(兵庫)
    • Year and Date
      2012-12-06
    • Related Report
      2013 Final Research Report
  • [Presentation] Transport of misfolded ER proteins to the cell surface by MHC class II molecules2012

    • Author(s)
      Yan Jiang,Hui Jin,Masako Kohyama,Noriko Arase,Kouyuki Hirayasu,Tadahiro Suenaga,Maki Matsumoto,Kyoko Shida,Lewis L. Lanier,Takashi Saito,Ichiro Katayama and Hisashi Arase
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸国際会議場(兵庫)
    • Year and Date
      2012-12-06
    • Related Report
      2013 Final Research Report
  • [Presentation] ヘルペスウイルス6型の膜融合はgB,gH,gL,gQによって引き起こされる2012

    • Author(s)
      田中悠喜、末永忠広、松本麻紀、森康子、荒瀬尚
    • Organizer
      第60回日本ウイルス学会学術集会
    • Place of Presentation
      グランキューブ大阪(大阪)
    • Year and Date
      2012-11-13
    • Related Report
      2013 Final Research Report
  • [Presentation] 水痘帯状庖疹ウイルス(VzV)の感染におけるシアル酸の役割2012

    • Author(s)
      末永忠広、松本麻紀、有津史倫、森康子、荒瀬尚
    • Organizer
      第60回日本ウイルス学会学術集会
    • Place of Presentation
      グランキューブ大阪(大阪)
    • Year and Date
      2012-11-13
    • Related Report
      2013 Final Research Report
  • [Presentation] 水痘帯状庖疹ウイルス(VzV)の膜融合におけるシアル酸の役割2012

    • Author(s)
      末永忠広、松本麻紀、有津史倫、森康子、荒瀬尚
    • Organizer
      第27回ヘルペスウイルス研究会
    • Place of Presentation
      あいち健康プラザ健康宿泊館プラザホール(愛知)
    • Year and Date
      2012-06-07
    • Related Report
      2013 Final Research Report
  • [Presentation] 神経指向性ヘルペスウイルスに対する糖鎖を利用した新規感染制御法2011

    • Author(s)
      末永 忠広
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      愛知県(名古屋国際会議場)
    • Related Report
      2011 Research-status Report
  • [Presentation] 水痘帯状疱疹ウイルス(VZV)の膜融合機序の解析2011

    • Author(s)
      末永忠広、松本麻紀、森康子、荒瀬尚
    • Organizer
      第26回ヘルペスウイルス研究会
    • Place of Presentation
      大阪市(大阪アカデミア)
    • Related Report
      2011 Research-status Report
  • [Presentation] Newly Identified Varicella-Zoster Virus(VZV) gB Receptor that Mediates Membrane Fusion and VZV Entry into Hematopoetic Cells2011

    • Author(s)
      Tadahiro Suenaga
    • Organizer
      36th International Herpesvirus Workshop
    • Place of Presentation
      Gdansk(Poland)
    • Related Report
      2011 Research-status Report
  • [Presentation] Newly Identified Varicella-Zoster Virus(VZV) Entry Receptor Expressed in Hematopoietic Cells2011

    • Author(s)
      Tadahiro Suenaga, Fuminori Arisawa, Yasuko Mori, Hisashi Arase
    • Organizer
      International Union of Microbiological Societies Congresses 2011
    • Place of Presentation
      Sapporo (JAPAN)
    • Related Report
      2011 Research-status Report
  • [Presentation] A Varicella-Zoster Virus entry receptor that expresses on hematopoietic cells2011

    • Author(s)
      T.Suenaga, M.Matsumoto, Y.Mori, H.Arase
    • Organizer
      15th International Conference on Immunobiology and Prophylaxis of Human Herpesvirus Infections
    • Place of Presentation
      San Servolo,Venice(Italy)
    • Related Report
      2011 Research-status Report
  • [Presentation] Rheumatoid factor binding to IgG heavy chain presented on HLA-DR is associated with Rheumatoid Arthritis susceptibility

    • Author(s)
      Jin Hui, Arase Noriko, Kohayama Masako, Saito Fumiji, Hirayasu Kouyuki, Matsumoto Maki, Shida Kyoko, Suenaga Tadahiro, Saito Takashi, Katayama Ichiro, Lanier Lewis L., Arase Hisashi
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] β2-glycoprotein I presented on MHC class II molecules are recognized by autoantibodies in antiphospholipid syndrome

    • Author(s)
      Tanimura Kenji, Suenaga Tadahiro, Jin Hui, Hirayasu Kouyuki, Arase Noriko, Kohayama Masako, Ebina Yasuhiko, Yasuda Shinsuke, Horita Tetsuya, Katayama Ichiro, Atsumi Tatsuya, Yamada Hideo, Arase Hisashi
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] PILRα negatively regulates DSS induced experimental colitis

    • Author(s)
      Kishida Kazuki, Kohyama Masako, Kurashima Yosuke, Wang Jing, Hirayasu Kouyuki, Suenaga Tadahiro, Kiyono Hiroshi, Kunisawa Jun, Arase Hisashi
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 水痘帯状疱疹ウイルス(VZV)の膜融合メカニズムの解析

    • Author(s)
      末永忠広、森康子、荒瀬尚
    • Organizer
      第61回日本ウイルス学会学術集会
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Herpesvirus 6 Glycoprotein B (gB), gH, gL and gQ are Necessary and Sufficient forCell-to-Cell Fusion

    • Author(s)
      Tadahiro Suenaga, Yuki Tanaka, Misako Matsumoto, Tsukasa Seya, Hisashi Arase
    • Organizer
      38th International Herpesvirus Workshop
    • Place of Presentation
      Grand Rapids, Michigan, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] 水痘帯状疱疹ウイルス(VZV)glycoprotein H (gH)受容体の解析

    • Author(s)
      末永忠広、松本麻紀、有澤史倫、森康子、荒瀬尚
    • Organizer
      第28回ヘルペスウイルス研究会
    • Place of Presentation
      淡路夢舞台国際会議場(淡路市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 水痘帯状疱疹ウイルス(VZV)の膜融合におけるシアル酸の役割

    • Author(s)
      末永忠広、松本麻紀、有澤 史倫、森康子、荒瀬尚
    • Organizer
      第27回ヘルペスウイルス研究会
    • Place of Presentation
      あいち健康プラザ健康宿泊館プラザホール(愛知県)
    • Related Report
      2012 Research-status Report
  • [Presentation] Glycoprotein B (gB), gH, gL, gQ1 and gQ2 of Human Herpesvirus 6 Mediate Membrane Fusion

    • Author(s)
      Yuki Tanaka, Tadahiro Suenaga, Maki Matsumoto, Yasuko Mori, Hisashi Arase
    • Organizer
      第11回あわじしま感染症・免疫フォーラム
    • Place of Presentation
      淡路夢舞台国際会議場(兵庫県)
    • Related Report
      2012 Research-status Report
  • [Presentation] Human cytomegalovirus UL10 regulates immune response via inhibitory PILRα

    • Author(s)
      Fuminori Arisawa, Jing Wang, Tadahiro Suenaga, Hisashi Arase
    • Organizer
      第11回あわじしま感染症・免疫フォーラム
    • Place of Presentation
      淡路夢舞台国際会議場(兵庫県)
    • Related Report
      2012 Research-status Report
  • [Presentation] 水痘帯状疱疹ウイルス(VZV)の感染におけるシアル酸の役割

    • Author(s)
      末永 忠広、松本 麻紀、有澤 史倫、森 康子、荒瀬 尚
    • Organizer
      第60回日本ウイルス学会学術集会
    • Place of Presentation
      グランキューブ大阪(大阪国際会議場)(大阪府)
    • Related Report
      2012 Research-status Report
  • [Presentation] ヘルペスウイルス6型の膜融合はgB, gH, gL, gQによって引き起こされる

    • Author(s)
      田中 悠喜、末永 忠広、松本 麻紀、森 康子、荒瀬 尚
    • Organizer
      第60回日本ウイルス学会学術集会
    • Place of Presentation
      グランキューブ大阪(大阪国際会議場)(大阪府)
    • Related Report
      2012 Research-status Report
  • [Presentation] Transport of misfolded ER proteins to the cell surface by MHC class II molecules

    • Author(s)
      Jiang, Y., Arase, N., Kohyama, M., Hirayasu, K., Suenaga, T., Jin, H., Matsumoto, M., Shida, K., L. Lanier, L., Saito, T. and Arase, H.
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Related Report
      2012 Research-status Report
  • [Presentation] Human cytomegalovirus UL10 regulates immune response via inhibitory PILRα

    • Author(s)
      Fuminori Arisawa, Jing Wang, Tadahiro Suenaga, Hisashi Arase
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://immchem.biken.osaka-u.ac.jp/

    • Related Report
      2013 Final Research Report
  • [Remarks] 免疫化学分野ホームページ

    • URL

      http://immchem.biken.osaka-u.ac.jp/

    • Related Report
      2013 Annual Research Report
  • [Remarks] 大阪大学微生物病研究所免疫化学分野

    • URL

      http://immchem.biken.osaka-u.ac.jp/

    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://immchem.biken.osaka-u.ac.jp/

    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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