Studies on the identification and acquisition mechanism ofcell-derived membrane on the surface of hepatitis E virus particles
| Project/Area Number |
23790508
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Virology
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
OKAMOTO Hiroaki 自治医科大学, 医学部, 教授 (30177092)
TAKAHASHI Masaharu 自治医科大学, 医学部, 講師 (70326841)
NISHIZAWA Tsutomu 自治医科大学, 医学部, 講師 (30306112)
KOBAYASHI Tominari 自治医科大学, 医学部, 助教 (00634164)
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| Research Collaborator |
YASUDA Jiro 長崎大学, 熱帯医学研究所, 教授 (10282518)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | E 型肝炎ウイルス / 粒子形成 / 放出 / MVB 経路 / Tsg101 / Vps4 / エンドソーム輸送 / E型肝炎ウイルス / MVB経路 / ESCRT機構 |
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| Research Abstract |
The present study revealed that HEV requires the MVB pathway for release of virus particles. Furthermore, our results indicate that membrane-associated HEV particles retain the antigenicity of TGOLN2 derived from TGN on the surface of the particles
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Report
(3 results)
Research Products
(10 results)
