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Studies on the identification and acquisition mechanism ofcell-derived membrane on the surface of hepatitis E virus particles

Research Project

Project/Area Number 23790508
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Virology
Research InstitutionJichi Medical University

Principal Investigator

NAGASHIMA Shigeo  自治医科大学, 医学部, 講師 (60433116)

Co-Investigator(Renkei-kenkyūsha) OKAMOTO Hiroaki  自治医科大学, 医学部, 教授 (30177092)
TAKAHASHI Masaharu  自治医科大学, 医学部, 講師 (70326841)
NISHIZAWA Tsutomu  自治医科大学, 医学部, 講師 (30306112)
KOBAYASHI Tominari  自治医科大学, 医学部, 助教 (00634164)
Research Collaborator YASUDA Jiro  長崎大学, 熱帯医学研究所, 教授 (10282518)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
KeywordsE 型肝炎ウイルス / 粒子形成 / 放出 / MVB 経路 / Tsg101 / Vps4 / エンドソーム輸送 / E型肝炎ウイルス / MVB経路 / ESCRT機構
Research Abstract

The present study revealed that HEV requires the MVB pathway for release of virus particles. Furthermore, our results indicate that membrane-associated HEV particles retain the antigenicity of TGOLN2 derived from TGN on the surface of the particles

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (10 results)

All 2013 2012 2011 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (4 results) Remarks (2 results)

  • [Journal Article] Frequent detection and characterization of hepatitis E virus variants in wild rats (Rattus rattus) in Indonesia2013

    • Author(s)
      Mulyanto
    • Journal Title

      Archives of Virology

      Volume: 158 Issue: 1 Pages: 87-96

    • DOI

      10.1007/s00705-012-1462-0

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular analysis of hepatitis E virus from farm rabbits in Inner Mongolia, China and its successful propagation in A549 and PLC/PRF/5 cells2012

    • Author(s)
      Jirintai S
    • Journal Title

      Virus Research

      Volume: 170 Issue: 1-2 Pages: 126-137

    • DOI

      10.1016/j.virusres.2012.09.015

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A549 and PLC/PRF/5 cells can support the efficient propagation of swine and wild boar hepatitis E virus (HEV) strains : demonstration of HEV infectivity of porcine liver sold as food2012

    • Author(s)
      Takahashi H
    • Journal Title

      Archives of Virology

      Volume: 157 Issue: 2 Pages: 235-246

    • DOI

      10.1007/s00705-011-1153-2

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Tumour susceptibility gene 101 and the vacuolar protein sorting pathway are required for the release of hepatitis E virions2011

    • Author(s)
      Nagashima S
    • Journal Title

      Journal of General Virology

      Volume: 92 Issue: 12 Pages: 2838-2848

    • DOI

      10.1099/vir.0.035378-0

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 培養細胞から放出された E 型肝炎ウイルスの粒子表面に存在する膜成分の抗原性の解析2012

    • Author(s)
      長嶋茂雄、高橋雅春、吉林台、西澤勉、小林富成、岡本宏明
    • Organizer
      第60回日本ウイルス学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2012-11-14
    • Related Report
      2012 Final Research Report
  • [Presentation] 培養細胞から放出されたE型肝炎ウイルスの粒子表面に存在する膜成分の抗原性の解析2012

    • Author(s)
      長嶋茂雄
    • Organizer
      第60回日本ウイルス学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
  • [Presentation] Tsg101 and the vacuolar protein sorting pathway are required for virion release of hepatitis E virus2011

    • Author(s)
      Nagashima S, Takahashi M, Jirintai, Tanaka T, Nishizawa T, Yasuda J, Okamoto H
    • Organizer
      15thInternational Congress of Virology (第59回日本ウイルス学会学術集会)
    • Place of Presentation
      札幌
    • Year and Date
      2011-09-13
    • Related Report
      2012 Final Research Report
  • [Presentation] Tsg101 and the vacuolar protein sorting pathway are required for virion release of hepatitis E virus.2011

    • Author(s)
      Nagashima S, Takahashi M, Jirintai, Tanaka T, Nishizawa T, Yasuda J, Okamoto H.
    • Organizer
      15th International Congress of Virology (第59回日本ウイルス学会学術集会)
    • Place of Presentation
      札幌
    • Related Report
      2011 Research-status Report
  • [Remarks] 自治医科大学 医学部 感染・免疫学講座ウイルス学部門

    • URL

      http://www.jichi.ac.jp/virology/

    • Related Report
      2012 Final Research Report
  • [Remarks] 自治医科大学医学部 感染・免疫学講座 ウイルス学部門

    • URL

      http://www.jichi.ac.jp/virology/

    • Related Report
      2012 Annual Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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