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Molecular mechanism of anti-HIV-1 activity mediated by Rac2

Research Project

Project/Area Number 23790510
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Virology
Research InstitutionKinki University

Principal Investigator

HAKATA Yoshiyuki  近畿大学, 医学部, 助教 (30344500)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsウイルス / HIV-1 / rac2 / 感染抵抗性因子 / 感染制御 / Rac2 / 感染抵抗性遺伝子
Research Abstract

We identified a new function of human Rac2. Rac2 negatively or positively regulates several cytokines production at transcriptional level. The transcriptional regulation by Rac2 involves specific molecules acting in cellular signal transduction pathway. The regulation of inflammatory cytokines would be the one of mechanisms by which Rac2 mediates the anti-HIV-1 activity. We found that Rac2 associates with viral proteins which can control autophagy. These interactions implied that Rac2 suppresses HIV-1 replication thorough modification of cellular autophagy activity controlled by viral proteins.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (5 results)

All 2012 2011 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results) Remarks (2 results)

  • [Journal Article] Two genetic determinants acquired late in Mus evolution regulate the inclusion of exon 5, which alters mouse APOBEC3 translation efficiency2012

    • Author(s)
      Li, J., Y. Hakata, E. Takeda, Q. Liu, Y. Iwatani, C. A. Kozak, M. Miyazawa
    • Journal Title

      PLoS Pathogens

      Volume: 8 Issue: 1 Pages: e1002478-e1002478

    • DOI

      10.1371/journal.ppat.1002478

    • NAID

      120006985441

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Vpr依存的G2期停止におけるVprと宿主因子との分子間相互作用2012

    • Author(s)
      博多 義之
    • Organizer
      第60回日本ウイルス学会学術集会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Functional consequences of mouse APOBEC3 gene polymorphisms and multiple genetic factors that influence the production of virus-neutralizing antibodies in Friend virus-infected mice2011

    • Author(s)
      Miyazawa, M., S. Tsuji-Kawahara, Y. Hakata, J. Li, E. Takeda, and C. Ishihara
    • Organizer
      The 23rd Workshop on Retroviral Pathogenesis
    • Place of Presentation
      Montpellier, France
    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.med.kindai.ac.jp/immuno/

    • Related Report
      2012 Final Research Report
  • [Remarks] 近畿大学医学部免疫学教室

    • URL

      http://www.med.kindai.ac.jp/immuno/

    • Related Report
      2012 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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