| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
EV71 typically causes mild hand-foot-and-mouth disease in children, but it can also cause severe neurological disease. However, there is little information available concerning EV71 neuropathogenesis. Thus, the development of an appropriate small animal model would greatly contribute to the study of this disease. Previously, we identified the human scavenger receptor class B, member 2 (hSCARB2) as a cellular receptor for EV71. In the current study, we generated a transgenic (Tg) mouse expressing hSCARB2 with an expression profile in similar to that in humans. Tg mice infected with EV71 exhibited ataxia, paralysis and death. The most severely affected cells were neurons in the spinal cord, brainstem, cerebellum, hypothalamus, thalamus and cerebrum. The pathological features in these Tg mice were generally similar to those of EV71 encephalomyelitis in humans. These results suggest that this Tg mouse could represent a useful animal model for the study of EV71.
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