| Project/Area Number |
23790521
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Immunology
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
KIMURA Shunsuke 北海道大学, 大学院・医学研究科, 助教 (40444525)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
|
|---|
| Keywords | パイエル板 / M細胞 / 粘膜免疫 / 細胞間相互作用 |
|---|
| Research Abstract |
Peyer's patch (PP) in the small intestine is a primary site for the intestinal immune system. The luminal side of PPs is covered by the follicle-associated epithelium (FAE), which contains M cells, which uptake antigens or macromolecules, and deliver them to dendritic cells inhabiting subepithelial dome region under FAE. CCR1 is a receptor of Ccl9 which is belonging to the CC chemokine family and highly expressed in M cells. We found that CCR1 positive cells inhabit subepithelial dome region, and some of them contact with M cells. Moreover, our study suggests that CCR1 positive cell belongs to a subtype of antigen-producing plasma cells.
|
