Research Project
Grant-in-Aid for Young Scientists (B)
Allergic disease, which is caused by a disorder of the balance of the immune system, is said to be the Japanese national disease. We focus on Th2 cells because they are thought to play leading role in development of the allergic disease. Polycomb and Trithorax proteins regulate Th2 cell function via binding to specific genes. We made gene maps of the place where they bound using an advanced technique called the ChIP-seq method and discovered some unexpected characteristics. In addition, we found that allergic reactions were attenuated in the mice lacking the Trithorax molecules. We hope that these findings will be applied to the development of therapies for allergic disease.
All 2013 2012 2011 Other
All Journal Article (13 results) (of which Peer Reviewed: 5 results) Presentation (21 results)
Proc Natl Acad Sci U SA
Volume: - Issue: 12 Pages: 4691-4696
10.1073/pnas.1220865110
Nat. Immunol.
Volume: 14 Issue: 2 Pages: 112-114
10.1038/ni.2510
非依存的な発現制御機構臨床免疫・アレルギー科(科学評論社)
Volume: 59(1) Pages: 25-33
臨床免疫・アレルギー科
Volume: 59 Pages: 25-33
Nat. Immunol
Volume: 13(8) Issue: 8 Pages: 778-786
10.1038/ni.2362
Menin/TrxG複合体によって維持される-臨床免疫・アレルギ-科
Volume: 57(3) Pages: 330-341
実験医学増刊免疫学のブラックボックス免疫記憶の制御と疾患治療
Volume: 29(17) Pages: 20-28
Cancer Res
Volume: 71 Issue: 14 Pages: 4790-4798
10.1158/0008-5472.can-10-1572
感染・炎症・免疫
Volume: 41(2) Pages: 22-31
J. Immunol
Volume: 186 Issue: 11 Pages: 6378-6389
10.4049/jimmunol.1100179
医学のあゆみ
Volume: 237(13) Pages: 1154-1160
Volume: 237(4) Pages: 314-314
Cancer Res.
Volume: 71 Pages: 4790-4798