The role of eosinophil in the gut homeostasis

• Project/Area Number: 23790529
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Immunology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: NAKANISHI Yusuke 東京医科歯科大学, 難治疾患研究所, 特任講師 (20579411)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 粘膜免疫 / 好酸球 / 炎症性腸疾患

Research Abstract

It is well known that eosinophil plays a critical role in the development of allergy or asthma. However, the role of eosinophil in the intestinal mucosa remains unknown. Here, we investigated the role of eosinophil in the development of ulcerative colitis, a representative inflammatory bowel disease (IBD). We found that, although eosinophil contributed to eliminate invading commensal bacteria, they did not play a major role in the development of ulcerative colitis.