| Project/Area Number |
23790530
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
KAWANO Youhei 東京医科歯科大学, 大学院・医歯学・総合研究科, 助教 (20401383)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | プレB細胞 / pre-BCR / リソソーム / タンパク分解 |
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| Research Abstract |
Pre-B cell receptor (pre-BCR) expression has to be strictly regulated for normal B cell development, and its dysregulation is associated with anomalies of B-lineage cells, including leukemogenesis. However, it remained elusive on the mechanism underlying pre-BCR down-modulation although transcriptional silencing of pre-BCR component is currently proposed. In this paper, we found that a lysosomal membrane protein, Laptm5 is up-regulated via autonomous pre-BCR signaling, followed by pre-BCR down-modulation by promoting its degradation in lysosomes. Of note, this finding suggests there is another mechanism of pre-BCR down-modulation at the protein level through the regulation of Laptm5.
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