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Thymic Sirpα^<+>DC subset conducts the novel process of intrathymic immune tolerance

Research Project

Project/Area Number 23790532
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Immunology
Research InstitutionKanazawa University

Principal Investigator

BABA Tomohisa  金沢大学, がん進展制御研究所, 助教 (00452095)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords胸腺 / 樹状細胞 / 制御性T細胞 / 免疫寛容
Research Abstract

The discrimination of self or non-self antigens is essential for the maintenance of intact immune system. In this study, we demonstrated that a thymic dendritic cell (DC) subset, Sirpα+ DC is the major conductor of the novel process of intrathymic immune tolerance against blood-borne antigens. Moreover, the secretory tumor-specific antigens can induce the intrathymic anti-tumor immune tolerance through the antigen presentation by thymic Sirpα+ DCs.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (17 results)

All 2013 2012 2011 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (8 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Decrease of peripheral and intestinal NKG2A-positive T cells in patients with ulcerative colitis2012

    • Author(s)
      Katsurada, T., Kobayashi, W., Tomaru, U.,Baba, T., Furukawa, S., Ishizu, A., Takeda, K., Sakamoto, N., Asaka, M., Takeda, H. and Kasahara, M
    • Journal Title

      PLoS ONE7

      Volume: (9) Issue: 9 Pages: e44113-e44113

    • DOI

      10.1371/journal.pone.0044113

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel process of intrathymic tumor-immune tolerance through CCR2-mediated recruitment of Sirp α+dendritic cells :a murine model2012

    • Author(s)
      Baba, T., Badr Mel, S., Tomaru, U., Ishizu, A., Mukaida, N
    • Journal Title

      PLoS ONE

      Volume: 7(7) Issue: 7 Pages: e41154-e41154

    • DOI

      10.1371/journal.pone.0041154

    • NAID

      120004419373

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chemokines in tumor development and progression2012

    • Author(s)
      Mukaida N, Baba T
    • Journal Title

      Experimental Cell Research

      Volume: 318(Invited Review) Issue: 2 Pages: 95-102

    • DOI

      10.1016/j.yexcr.2011.10.012

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Identification of a phenanthrene derivative as a potent anti-cancer drug with Pim kinase inhibitory activities2012

    • Author(s)
      Wang Y-Y, Taniguchi T, Baba T, Li Y-Y, Ishibashi H, and Mukaida N
    • Journal Title

      Cancer Sci

      Volume: 103(1) Issue: 1 Pages: 107-115

    • DOI

      10.1111/j.1349-7006.2011.02117.x

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mechanism of Fc γreceptor-mediated trogocytosis-based false-positive results in flow cytometry2012

    • Author(s)
      Masuda, S., Iwasaki, S., Tomaru, U., Sato, J., Kawakami, A., Ichijo, K., Sogo, S., Baba, T.,Katsumata, K., Kasahara, M. and Ishizu, A
    • Journal Title

      PLoS ONE

      Volume: 7(12) Issue: 12 Pages: e52918-e52918

    • DOI

      10.1371/journal.pone.0052918

    • NAID

      120005183187

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decreased proteasomal activity causes age-related phenotypes and promotes the development of metabolic abnormalities2012

    • Author(s)
      Tomaru U, Takahashi S, Ishizu A, Miyatake Y, Gohda A, Suzuki S, Ono A, Ohara J, Baba T, Murata S, Tanaka K, Kasahara M
    • Journal Title

      Am.J.Pathol.

      Volume: 180 Issue: 3 Pages: 963-972

    • DOI

      10.1016/j.ajpath.2011.11.012

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Novel process of intrathymic immune tolerance against secretory tumorspecific antigens2012

    • Author(s)
      馬場智久, 向田直史
    • Organizer
      第41回日本免疫学会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Year and Date
      2012-12-05
    • Related Report
      2012 Final Research Report
  • [Presentation] Thymic Sirp alpha+ DC subset conducts the novel process of intrathymic tumor-immune tolerance2012

    • Author(s)
      馬場智久, 向田直史
    • Organizer
      第71回日本癌学会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Year and Date
      2012-09-19
    • Related Report
      2012 Final Research Report
  • [Presentation] Intrathymic perivascular dendritic 図2 血中抗原に対するcentral toleranceの誘導 cells capturing blood-borne antigens conduct central tolerance2011

    • Author(s)
      馬場智久, 向田直史
    • Organizer
      第6回研究所ネットワーク国際シンポジウム
    • Place of Presentation
      東京医科歯科大学(東京都)
    • Year and Date
      2011-06-09
    • Related Report
      2012 Final Research Report
  • [Presentation] 胸腺perivascular DCによる血中抗原の取り込みと制御性T細胞の分化誘導2011

    • Author(s)
      馬場 智久
    • Organizer
      日本免疫学会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Related Report
      2011 Research-status Report
  • [Presentation] Intrathymic perivascular dendritic cells capturing blood-borne antigens conduct central tolerance2011

    • Author(s)
      馬場 智久
    • Organizer
      研究所ネットワーク国際シンポジウム
    • Place of Presentation
      東京医科歯科大学(東京都)
    • Related Report
      2011 Research-status Report
  • [Presentation] Thymic Sirp alpha+ DC subset conducts the novel process of intrathymic tumor-immune tolerance

    • Author(s)
      馬場 智久
    • Organizer
      日本癌学会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Novel process of intrathymic immune tolerance against secretory tumor-specific antigens

    • Author(s)
      馬場 智久
    • Organizer
      日本免疫学会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Establishment of CML mouse model to examine the interactive role of normal hematopoietic system on the pathophysiology

    • Author(s)
      馬場 智久
    • Organizer
      3rd International Symposium on Carcinogenic Spiral and International Symposium on Tumor Biology in Kanazawa
    • Place of Presentation
      エクセルホテル東急(石川県)
    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.kanazawa-u.ac.jp/~ganken/bunsiseitai/JapContent.html

    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] 慢性骨髄性白血病モデル動物2013

    • Inventor(s)
      馬場智久, 向田直史
    • Industrial Property Rights Holder
      金沢大学
    • Industrial Property Number
      2013-011556
    • Filing Date
      2013-01-24
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] 慢性骨髄性白血病モデル動物2013

    • Inventor(s)
      馬場 智久、  向田 直史
    • Industrial Property Rights Holder
      金沢大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-011556
    • Filing Date
      2013-01-24
    • Related Report
      2012 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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