Thymic Sirpα^<+>DC subset conducts the novel process of intrathymic immune tolerance

• Project/Area Number: 23790532
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Immunology
• Research Institution: Kanazawa University
• Principal Investigator: BABA Tomohisa 金沢大学, がん進展制御研究所, 助教 (00452095)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 胸腺 / 樹状細胞 / 制御性T細胞 / 免疫寛容

Research Abstract

The discrimination of self or non-self antigens is essential for the maintenance of intact immune system. In this study, we demonstrated that a thymic dendritic cell (DC) subset, Sirpα+ DC is the major conductor of the novel process of intrathymic immune tolerance against blood-borne antigens. Moreover, the secretory tumor-specific antigens can induce the intrathymic anti-tumor immune tolerance through the antigen presentation by thymic Sirpα+ DCs.

Research Products

• [Journal Article] Decrease of peripheral and intestinal NKG2A-positive T cells in patients with ulcerative colitis (2012)
  • Author(s): Katsurada, T., Kobayashi, W., Tomaru, U.,Baba, T., Furukawa, S., Ishizu, A., Takeda, K., Sakamoto, N., Asaka, M., Takeda, H. and Kasahara, M
  • Journal Title: PLoS ONE7 Volume: (9) Issue: 9 Pages: e44113-e44113
  • DOI: 10.1371/journal.pone.0044113
  • Peer Reviewed
• [Journal Article] Novel process of intrathymic tumor-immune tolerance through CCR2-mediated recruitment of Sirp α+dendritic cells :a murine model (2012)
  • Author(s): Baba, T., Badr Mel, S., Tomaru, U., Ishizu, A., Mukaida, N
  • Journal Title: PLoS ONE Volume: 7(7) Issue: 7 Pages: e41154-e41154
  • DOI: 10.1371/journal.pone.0041154
  • NAID: 120004419373
  • Peer Reviewed
• [Journal Article] Chemokines in tumor development and progression (2012)
  • Author(s): Mukaida N, Baba T
  • Journal Title: Experimental Cell Research Volume: 318(Invited Review) Issue: 2 Pages: 95-102
  • DOI: 10.1016/j.yexcr.2011.10.012
  • Peer Reviewed
• [Journal Article] Identification of a phenanthrene derivative as a potent anti-cancer drug with Pim kinase inhibitory activities (2012)
  • Author(s): Wang Y-Y, Taniguchi T, Baba T, Li Y-Y, Ishibashi H, and Mukaida N
  • Journal Title: Cancer Sci Volume: 103(1) Issue: 1 Pages: 107-115
  • DOI: 10.1111/j.1349-7006.2011.02117.x
  • Peer Reviewed
• [Journal Article] Mechanism of Fc γreceptor-mediated trogocytosis-based false-positive results in flow cytometry (2012)
  • Author(s): Masuda, S., Iwasaki, S., Tomaru, U., Sato, J., Kawakami, A., Ichijo, K., Sogo, S., Baba, T.,Katsumata, K., Kasahara, M. and Ishizu, A
  • Journal Title: PLoS ONE Volume: 7(12) Issue: 12 Pages: e52918-e52918
  • DOI: 10.1371/journal.pone.0052918
  • NAID: 120005183187
  • Peer Reviewed
• [Journal Article] Decreased proteasomal activity causes age-related phenotypes and promotes the development of metabolic abnormalities (2012)
  • Author(s): Tomaru U, Takahashi S, Ishizu A, Miyatake Y, Gohda A, Suzuki S, Ono A, Ohara J, Baba T, Murata S, Tanaka K, Kasahara M
  • Journal Title: Am.J.Pathol. Volume: 180 Issue: 3 Pages: 963-972
  • DOI: 10.1016/j.ajpath.2011.11.012
  • Peer Reviewed
• [Presentation] Novel process of intrathymic immune tolerance against secretory tumorspecific antigens (2012)
  • Author(s): 馬場智久, 向田直史
  • Organizer: 第41回日本免疫学会
  • Place of Presentation: 神戸国際会議場(兵庫県)
  • Year and Date: 2012-12-05
• [Presentation] Thymic Sirp alpha+ DC subset conducts the novel process of intrathymic tumor-immune tolerance (2012)
  • Author(s): 馬場智久, 向田直史
  • Organizer: 第71回日本癌学会
  • Place of Presentation: ロイトン札幌(北海道)
  • Year and Date: 2012-09-19
• [Presentation] Intrathymic perivascular dendritic 図2 血中抗原に対するcentral toleranceの誘導 cells capturing blood-borne antigens conduct central tolerance (2011)
  • Author(s): 馬場智久, 向田直史
  • Organizer: 第6回研究所ネットワーク国際シンポジウム
  • Place of Presentation: 東京医科歯科大学(東京都)
  • Year and Date: 2011-06-09
• [Presentation] 胸腺perivascular DCによる血中抗原の取り込みと制御性T細胞の分化誘導 (2011)
  • Author(s): 馬場 智久
  • Organizer: 日本免疫学会
  • Place of Presentation: 幕張メッセ（千葉県）
• [Presentation] Intrathymic perivascular dendritic cells capturing blood-borne antigens conduct central tolerance (2011)
  • Author(s): 馬場 智久
  • Organizer: 研究所ネットワーク国際シンポジウム
  • Place of Presentation: 東京医科歯科大学（東京都）
• [Presentation] Thymic Sirp alpha+ DC subset conducts the novel process of intrathymic tumor-immune tolerance
  • Author(s): 馬場 智久
  • Organizer: 日本癌学会
  • Place of Presentation: ロイトン札幌（北海道）
• [Presentation] Novel process of intrathymic immune tolerance against secretory tumor-specific antigens
  • Author(s): 馬場 智久
  • Organizer: 日本免疫学会
  • Place of Presentation: 神戸国際会議場（兵庫県）
• [Presentation] Establishment of CML mouse model to examine the interactive role of normal hematopoietic system on the pathophysiology
  • Author(s): 馬場 智久
  • Organizer: 3rd International Symposium on Carcinogenic Spiral and International Symposium on Tumor Biology in Kanazawa
  • Place of Presentation: エクセルホテル東急（石川県）
• [Remarks]
  • URL: http://www.kanazawa-u.ac.jp/~ganken/bunsiseitai/JapContent.html
• [Patent(Industrial Property Rights)] 慢性骨髄性白血病モデル動物 (2013)
  • Inventor(s): 馬場智久, 向田直史
  • Industrial Property Rights Holder: 金沢大学
  • Industrial Property Number: 2013-011556
  • Filing Date: 2013-01-24
• [Patent(Industrial Property Rights)] 慢性骨髄性白血病モデル動物 (2013)
  • Inventor(s): 馬場 智久、 向田 直史
  • Industrial Property Rights Holder: 金沢大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2013-011556
  • Filing Date: 2013-01-24