PD-1 and novel immune-regulatory molecules in T cell differentiation.

• Project/Area Number: 23790534
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Immunology
• Research Institution: Kyoto University
• Principal Investigator: CHIKUMA Shunsuke 京都大学, 医学研究科, 助教 (50437208)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: T細胞 / 副刺激 / 免疫寛容 / 免疫抑制 / がん免疫 / 自己免疫疾患

Research Abstract

Biochemical and immunological experiments were carried out to elucidate roles of ITAG1, a novel molecule regulated by PD-1 during immune tolerance induction. I found that ITAG1 interacted with known transcriptional factor and chromatin regulators, suggesting its role in T cell differentiation. In contrast, ITAG1 knockout mice showed only minor defect, suggesting some compensatory mechanism in the knockout mice.

Research Products

• [Journal Article] (2012)
  • Author(s): Chikuma S, Suita N, Okazaki IM, Shibayama S, Honjo T
  • Journal Title: Nat. Immunol. Volume: 13 Issue: 6 Pages: 596-603
  • DOI: 10.1038/ni.2293
• [Journal Article] (2012)
  • Author(s): Hara-Chikuma M, Chikuma S, Sugiyama Y, Kabashima K, Verkman AS, Inoue S, Miyachi Y.
  • Journal Title: J. Exp. Med Volume: 209 Pages: 1743-52
  • URL: http://jem.rupress.org/content/209/10/1743.long
• [Journal Article] (2011)
  • Author(s): Qin H, Suzuki K, Nakata M, Chikuma S, Izumi N, Huong LT, Maruya M, Fagarasan S, Busslinger M, Honjo T, Nagaoka H
  • Journal Title: Plos One Volume: 6
  • URL: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0029141
• [Journal Article] Activation-induced cytidine deaminase expression in CD4+ T cells is associated with a unique IL-10-producing subset that increases with age. (2011)
  • Author(s): Qin H, Suzuki K, Nakata M, Chikuma S, Izumi N, Huong le T, Maruya M, Fagarasan S, Busslinger M, Honjo T, Nagaoka H
  • Journal Title: PLoS One Volume: 6
  • Peer Reviewed
• [Presentation] 抗 PD-1 抗体によるがん治療法 (2012)
  • Author(s): 竹馬 俊介
  • Organizer: 日台癌のトランスレーショナル研究シンポジウム
  • Place of Presentation: 神戸
  • Year and Date: 2012-11-21
• [Presentation] 北海道大学獣医学部 学術交流資金群講演会 (2012)
  • Author(s): 竹馬 俊介
  • Organizer: 自己免疫疾患研究の最先端
  • Place of Presentation: 札幌
  • Year and Date: 2012-11-01
• [Presentation] T cell-expression of Trim28 prevents development of auto-inflammatory T cells (2011)
  • Author(s): Shunsuke Chikuma
  • Organizer: 2nd CSI/JSI/KAI Joint Symposium on Immunology（日中韓免疫シンポジウム）(招待講演)
  • Place of Presentation: Osaka University（大阪府）
• [Presentation] 核内因子TRIM28による自己炎症性T細胞の制御
  • Author(s): 竹馬 俊介
  • Organizer: 北海道大学獣医学部 学術交流資金群講演会
  • Place of Presentation: 札幌
  • Invited
• [Presentation] 抗PD-1抗体によるがん治療法
  • Author(s): 竹馬 俊介
  • Organizer: 日台癌のトランスレーショナル研究シンポジウム
  • Place of Presentation: 神戸
  • Invited
• [Book] TRIM28 と自己免疫応答 (2013)
  • Author(s): 竹馬 俊介
  • Publisher: 医学のあゆみ
• [Remarks] クロマチン制御因子 TRIM28 は、T細胞性自己免疫疾患を抑制する
  • URL: http://www.kyoto-u.ac.jp/ja/news_data/h/h1/news6/2012/120430_1.htm
• [Remarks] クロマチン制御因子TRIM28は、Ｔ細胞性自己免疫疾患を抑制する
  • URL: http://www.kyoto-u.ac.jp/ja/news_data/h/h1/news6/2012/120430_1.htm