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Comprehensive screening and identification of novel molecules involved in the spatiotemoral regulation of endosomes in plasmacytoid dendritic cells

Research Project

Project/Area Number 23790535
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Immunology
Research InstitutionKyoto University

Principal Investigator

KITAWAKI Toshio  京都大学, 医学(系)研究科(研究院), 助教 (50378684)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords自然免疫 / 形質細胞様樹状細胞 / I型インターフェロン / 二重レポーターシステム / エンドソーム / IRF7 / レポーターシステム / DNAマイクロアレイ / DNAメチル化解析 / レトロウイルス挿入変異 / 生体防御 / 分子メカニズム
Research Abstract

Plasmacytoid dendritic cells (pDC) rapidly produce vast amounts of type I interferon in response to nucleic acids. They play an important role in host defense by responding to pathogen-derived nucleic acids. However, they are also involved in the pathogenesis of immune disorders by responding to self-cell-derived nucleic acids. In this project, we performed our research to clarify mechanisms of type I interferon production by pDC, using a human pDC cell line established in our laboratory, by introducing it a dual reporter system that visualize activation dynamics of endosomes.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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