| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
We have identified that CX3CR1high CD11b+ CD11c+ myeloid cells (regulatory myeloid cells: Mreg cells) preferentially interacted with effector T cells via high expression of ICAM-1/VCAM, but did not activate effector T cells owing to the IL-10/Stat3-dependent suppression of CD80 and CD86 expression. In addition, our study showed that the severity of intestinal inflammation was improved by administration of wild-type Mreg cells in LysM-cre; Stat3flox/flox mice with Mreg cells lacking suppressive activity. These findings indicate the possibility that the impaired Mreg function is responsible for onset or/and progression of IBD.
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