Analysis of mechanisms by which CX3CR1high myeloid cells regulate gut homeostais
Project/Area Number |
23790536
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Immunology
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Research Institution | Osaka University |
Principal Investigator |
KAYAMA Hisako 大阪大学, 医学(系)研究科(研究院), 助教 (40548814)
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Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | 腸管免疫 / 自然免疫 / 粘膜免疫 / IBD / 制御性細胞 / 自然免疫細胞 |
Research Abstract |
We have identified that CX3CR1high CD11b+ CD11c+ myeloid cells (regulatory myeloid cells: Mreg cells) preferentially interacted with effector T cells via high expression of ICAM-1/VCAM, but did not activate effector T cells owing to the IL-10/Stat3-dependent suppression of CD80 and CD86 expression. In addition, our study showed that the severity of intestinal inflammation was improved by administration of wild-type Mreg cells in LysM-cre; Stat3flox/flox mice with Mreg cells lacking suppressive activity. These findings indicate the possibility that the impaired Mreg function is responsible for onset or/and progression of IBD.
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] Ecto-nucleoside triphosphate diphosphohydrolase 7 controls Th17 cell responses through regulation of luminal ATP in the small intestine2013
Author(s)
Kusu T, Kayama H, Kinoshita M, Jeon SG, Ueda Y, Goto Y, Okumura R, Saiga H, Kurakawa T, Ikeda K, Kunisawa J, Kiyono H, Okumura M, Yamamoto M, Takeda K.
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Journal Title
J Immunol
Volume: 190(2)
Pages: 774-83
Related Report
Peer Reviewed
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[Journal Article] CREBH determines the severity of sulpyrine-induced fatal shock.2013
Author(s)
Kamiyama N, Yamamoto M, Saiga H, Ma JS, Ohshima J, Machimura S, Sasai M, Kimura T, Ueda Y, Kayama H, Takeda K.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Intestinal CX3C chemokine receptor 1high (CX3CR1high) myeloid cells prevent T-cell-dependent colitis2012
Author(s)
Kayama H, Ueda Y, Sawa Y, Jeon SG, Ma JS, Okumura R, Kubo A, Ishii M, Okazaki T, Murakami M, Yamamoto M, Yagita H, Takeda K.
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Journal Title
Proc Natl Acad Sci USA.
Volume: in press
Related Report
Peer Reviewed
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[Journal Article] Probiotic Bifidobacterium breve induces IL-10-producing Tr1 cells in the colon2012
Author(s)
Jeon SG *, Kayama H *, Ueda Y, Takahashi T, Asahara T, Tsuji T, Tsuji M.N, Kiyono H, Ma JS Kusu T, Okumura R, Hara H, Yoshida H, Yamamoto M, Nomoto K, Takeda K
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Journal Title
PLoS Pathogs
Volume: in press
Related Report
Peer Reviewed
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[Journal Article] The lactic acid bacterium Pediococcus acidilactici suppresses autoimmune encephalomyelitis by inducing IL-10-producing regulatory T cells2011
Author(s)
Takata K, Kinoshita M, Okuno T, Moriya M, Kohda T, Honorat JA, Sugimoto T, Kumanogoh A, Kayama H, Takeda K, Sakoda S, Nakatsuji Y.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] ATF6beta is a host cellular target of the Toxoplasma gondii virulence factor ROP182011
Author(s)
amamoto M, Ma JS, Mueller C, Kamiyama N, Saiga H, Kubo E, Kimura T, Okamoto T, Okuyama M, Kayama H, Nagamune K, Takashima S, Matsuura Y, Soldati-Favre D, Takeda K.
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Journal Title
J.Exp.Med.
Volume: 208 (7)
Pages: 1533-46
Related Report
Peer Reviewed
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[Book] 細胞工学2013
Author(s)
香山尚子・西村潤一・竹田潔
Total Pages
5
Publisher
学研メディカル秀潤社
Related Report
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[Book] 実験医学2011
Author(s)
香山尚子、竹田潔
Total Pages
8
Publisher
自然免疫系による炎症性腸疾患制御の分子メカニズム
Related Report
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