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Analysis of mechanisms by which CX3CR1high myeloid cells regulate gut homeostais

Research Project

Project/Area Number 23790536
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Immunology
Research InstitutionOsaka University

Principal Investigator

KAYAMA Hisako  大阪大学, 医学(系)研究科(研究院), 助教 (40548814)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords腸管免疫 / 自然免疫 / 粘膜免疫 / IBD / 制御性細胞 / 自然免疫細胞
Research Abstract

We have identified that CX3CR1high CD11b+ CD11c+ myeloid cells (regulatory myeloid cells: Mreg cells) preferentially interacted with effector T cells via high expression of ICAM-1/VCAM, but did not activate effector T cells owing to the IL-10/Stat3-dependent suppression of CD80 and CD86 expression. In addition, our study showed that the severity of intestinal inflammation was improved by administration of wild-type Mreg cells in LysM-cre; Stat3flox/flox mice with Mreg cells lacking suppressive activity. These findings indicate the possibility that the impaired Mreg function is responsible for onset or/and progression of IBD.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report

Research Products

(37 results)

All 2017 2013 2012 2011

All Journal Article Presentation Book

  • [Journal Article] Insight into the flagella type III export revealed by the complex structure of the type III ATPase and its regulator.2017

    • Author(s)
      Imada, K., Minamino, T., Uchida, Y., Kinoshita, M., Namba, K.
    • Journal Title

      PNAS

      Volume: 110 Issue: 13 Pages: 12271-12276

    • DOI
      10.1073/pnas
    • Related Report
      2013 Final Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Ecto-nucleoside triphosphate diphosphohydrolase 7 controls Th17 cell responses through regulation of luminal ATP in the small intestine2013

    • Author(s)
      Kusu T, Kayama H, Kinoshita M, Jeon SG, Ueda Y, Goto Y, Okumura R, Saiga H, Kurakawa T, Ikeda K, Kunisawa J, Kiyono H, Okumura M, Yamamoto M, Takeda K.
    • Journal Title

      J Immunol

      Volume: 190(2) Pages: 774-83

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] CREBH determines the severity of sulpyrine-induced fatal shock.2013

    • Author(s)
      Kamiyama N, Yamamoto M, Saiga H, Ma JS, Ohshima J, Machimura S, Sasai M, Kimura T, Ueda Y, Kayama H, Takeda K.
    • Journal Title

      . PLoS One

      Volume: 8(2)

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Regulation of intestinal homeostasis by innate and adaptive immunity2012

    • Author(s)
      Kayama H, Takeda K
    • Journal Title

      Int Immunol

      Volume: 24(11) Pages: 673-80

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dietary folic acid promotes survival of Foxp3+ regulatory T cells in the colon2012

    • Author(s)
      Kinoshita M, Kayama H, Kusu T, Yamaguchi T, Kunisawa J, Kiyono H, Sakaguchi S, Takeda K
    • Journal Title

      J.Immunol

      Volume: 189(6) Pages: 2869-78

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Intestinal CX3C chemokine receptor 1high (CX3CR1high) myeloid cells prevent T-cell-dependent colitis2012

    • Author(s)
      Kayama H, Ueda Y, Sawa Y, Jeon SG, Ma JS, Okumura R, Kubo A, Ishii M, Okazaki T, Murakami M, Yamamoto M, Yagita H, Takeda K.
    • Journal Title

      Proc Natl Acad Sci USA.

      Volume: in press

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Probiotic Bifidobacterium breve induces IL-10-producing Tr1 cells in the colon2012

    • Author(s)
      Jeon SG *, Kayama H *, Ueda Y, Takahashi T, Asahara T, Tsuji T, Tsuji M.N, Kiyono H, Ma JS Kusu T, Okumura R, Hara H, Yoshida H, Yamamoto M, Nomoto K, Takeda K
    • Journal Title

      PLoS Pathogs

      Volume: in press

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] The lactic acid bacterium Pediococcus acidilactici suppresses autoimmune encephalomyelitis by inducing IL-10-producing regulatory T cells2011

    • Author(s)
      Takata K, Kinoshita M, Okuno T, Moriya M, Kohda T, Honorat JA, Sugimoto T, Kumanogoh A, Kayama H, Takeda K, Sakoda S, Nakatsuji Y.
    • Journal Title

      PLoS One

      Volume: 6 (11)

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] ATF6beta is a host cellular target of the Toxoplasma gondii virulence factor ROP182011

    • Author(s)
      amamoto M, Ma JS, Mueller C, Kamiyama N, Saiga H, Kubo E, Kimura T, Okamoto T, Okuyama M, Kayama H, Nagamune K, Takashima S, Matsuura Y, Soldati-Favre D, Takeda K.
    • Journal Title

      J.Exp.Med.

      Volume: 208 (7) Pages: 1533-46

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 制御性ミエロイド細胞による炎症性腸疾患抑制機構2012

    • Author(s)
      香山尚子
    • Organizer
      日本臨床免疫学会
    • Place of Presentation
      東京、日本
    • Related Report
      2013 Final Research Report
  • [Presentation] 腸管粘膜固有層における制御性ミエロイド細胞依存的な獲得免疫系制御機構2012

    • Author(s)
      香山尚子
    • Organizer
      日本インターフェロン・サイトカイン学会
    • Place of Presentation
      神戸・日本
    • Related Report
      2013 Final Research Report
  • [Presentation] 腸管粘膜固有層における制御性ミエロイド細胞依存的な獲得免疫系制御機構2012

    • Author(s)
      香山尚子、竹田潔
    • Organizer
      第77回日本インターフェロンサイトカイン学会
    • Place of Presentation
      日本・神戸
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 制御性ミエロイド細胞による炎症性腸疾患制御機構2012

    • Author(s)
      香山尚子、竹田潔
    • Organizer
      第40回日本臨床免疫学会
    • Place of Presentation
      日本・東京
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Bifidobacterium breve induces IL-10-producing typeI regulatory T cell (Tr1) in the colon2012

    • Author(s)
      香山尚子、Seong Gyu Jeon、竹田潔
    • Organizer
      第41回日本免疫学会
    • Place of Presentation
      日本・神戸
    • Related Report
      2012 Research-status Report
  • [Presentation] Probiotic Bifidobacterium breve induces IL-10-producing Tr1 cells2012

    • Author(s)
      Hisako Kayama, Seong Gyu , Kiyoshi Takeda
    • Organizer
      keystone symposia
    • Place of Presentation
      アメリカ合衆国 コロラド州
    • Related Report
      2011 Research-status Report
  • [Presentation] Regulatory myeloid cells prevent T cell dependent colitis in lamina propria2011

    • Author(s)
      Hisako Kayama
    • Organizer
      日本免疫学会
    • Place of Presentation
      千葉,日本
    • Related Report
      2013 Final Research Report
  • [Presentation] Intestinal Gr-1highCD11b+CD11c+ cells prevent T cell dependent colitis2011

    • Author(s)
      Hisako Kayama
    • Organizer
      IInternational Congress of Mucosal Immunology
    • Place of Presentation
      Paris, France
    • Related Report
      2013 Final Research Report
  • [Presentation] Regulatory myeloid cells prevent T-cell dependent colitis in lamina propria2011

    • Author(s)
      Hisako Kayama, Yoshiyasu Ueda, Kiyoshi Takeda
    • Organizer
      日本免疫学会
    • Place of Presentation
      千葉
    • Related Report
      2011 Research-status Report
  • [Presentation] Intestinal Gr-1highCD11b+CD11c+ cells prevent T cell-dependent colitis.2011

    • Author(s)
      Hisako Kayama
    • Organizer
      Inernational Congress of Mucosal Immunology
    • Place of Presentation
      フランス パリ
    • Related Report
      2011 Research-status Report
  • [Book] 炎症と免疫 巻:21 号:4 制御性ミエロイド細胞2013

    • Author(s)
      香山尚子・竹田潔
    • Related Report
      2013 Final Research Report
  • [Book] 日本消化器学会雑誌 巻:110 号:5 消化管疾患と自然免疫研究の進歩2013

    • Author(s)
      香山尚子・竹田潔
    • Related Report
      2013 Final Research Report
  • [Book] 医学のあゆみ 巻:246 号:11 自然免疫細胞による腸管粘膜免疫系の制御2013

    • Author(s)
      香山尚子・竹田潔
    • Related Report
      2013 Final Research Report
  • [Book] 細胞工学 巻:32 号:12 自然免疫細胞による腸管免疫制御2013

    • Author(s)
      香山尚子・西村潤一・竹田潔
    • Related Report
      2013 Final Research Report
  • [Book] 炎症と免疫2013

    • Author(s)
      香山尚子・竹田潔
    • Total Pages
      5
    • Publisher
      先端医学社
    • Related Report
      2013 Annual Research Report
  • [Book] 日本消化器学会雑誌2013

    • Author(s)
      香山尚子・竹田潔
    • Total Pages
      11
    • Publisher
      日本消化器学会
    • Related Report
      2013 Annual Research Report
  • [Book] 医学のあゆみ2013

    • Author(s)
      香山尚子・竹田潔
    • Total Pages
      5
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2013 Annual Research Report
  • [Book] 細胞工学2013

    • Author(s)
      香山尚子・西村潤一・竹田潔
    • Total Pages
      5
    • Publisher
      学研メディカル秀潤社
    • Related Report
      2013 Annual Research Report
  • [Book] 細胞工学 巻:31 号:11 制御性ミエロイド(Mreg)細胞による腸管炎症制御2012

    • Author(s)
      香山尚子・竹田潔
    • Related Report
      2013 Final Research Report
  • [Book] 実験医学 巻:30 号:20 腸管粘膜における制御性ミエロイド細胞2012

    • Author(s)
      香山尚子・竹田潔
    • Related Report
      2013 Final Research Report
  • [Book] 免疫学Update 腸内細菌と免疫細胞サブセット2012

    • Author(s)
      香山尚子・竹田潔
    • Related Report
      2013 Final Research Report
  • [Book] 免疫学Update2012

    • Author(s)
      香山尚子、竹田潔
    • Total Pages
      7
    • Publisher
      南山堂
    • Related Report
      2012 Research-status Report
  • [Book] 感染・共生・生体防御システム2012

    • Author(s)
      香山尚子、竹田潔
    • Total Pages
      7
    • Publisher
      羊土社
    • Related Report
      2012 Research-status Report
  • [Book] 細胞工学 巻:30 号:4 腸管マクロファージによる炎症制御2011

    • Author(s)
      香山尚子・竹田潔
    • Related Report
      2013 Final Research Report
  • [Book] 実験医学 巻:29 号:10 自然免疫系による炎症性腸疾患制御の分子メカニズム2011

    • Author(s)
      香山尚子・竹田潔
    • Related Report
      2013 Final Research Report
  • [Book] IBD Resarch 巻:5 号:4 自然免疫とはなんですか? IBDの視点から2011

    • Author(s)
      香山尚子・竹田潔
    • Related Report
      2013 Final Research Report
  • [Book] 実験医学2011

    • Author(s)
      香山尚子、竹田潔
    • Total Pages
      8
    • Publisher
      自然免疫系による炎症性腸疾患制御の分子メカニズム
    • Related Report
      2011 Research-status Report
  • [Book] IBD Reserch2011

    • Author(s)
      香山尚子
    • Total Pages
      4
    • Publisher
      自然免疫とはなんですか?IBDの視点から
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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