Lympho-epithelial interactions in the thymus for T-cell repertoire formation
| Project/Area Number |
23790540
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Immunology
|
|---|
| Research Institution | Research Institute, International Medical Center of Japan |
|---|
Principal Investigator |
NITTA Takeshi 独立行政法人国立国際医療研究センター, 研究所, 室長 (30373343)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 獲得免疫 / 胸腺 / 免疫 / T細胞 / 胸腺上皮細胞 |
|---|
| Research Abstract |
Distinct subsets of thymic epithelial cells support development of repertoire selection of T cells. We found that cortical thymic epithelial cells form multicellular complexes that closely associate with many viable thymocytes. The complexes that completely enclose thymocytes were found to be identical to previously described “thymic nurse cells (TNCs)”. Our results showed that the formation of TNC complexes requires pre-selected CD4^+CD8^+ thymocytes in postnatal thymus. Cells within TNC complexes were enriched for long-lived CD4^+CD8^+ thymocytes that have undergone secondary TCRα rearrangement. These results indicate that cortical thymic epithelial cells interact with pre-selected CD4^+CD8^+ thymocytes to form TNC complexes that provide a microenvironment supporting secondary TCRα rearrangement and T-cell selection.
|
Report
(3 results)
Research Products
(15 results)
-
-
-
-
[Journal Article] Rank signaling links the development of invariant γδ T cell progenitors and Aire+ medullary epithelium2012
Author(s)
Roberts NM, White AJ, Jenkinson WE, Turchinovich G, Nakamura K, Withers DR, McConnell FM, Desanti GE, Benezech C, Parnell SM, Cunningham AF, Paolino M, Penninger J, Simon K, Nitta T, Ohigashi I, Takahama Y, Caamano JH, Hayday AC, Lane PJ, Jenkinson EJ, Anderson G
-
Journal Title
Immunity
Volume: 36
Issue: 3
Pages: 427-437
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
