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Function analysis of MASP-1 as a therapeutic target for lupus-pronenephritis in MRL/lpr mice

Research Project

Project/Area Number 23790542
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Immunology
Research InstitutionFukushima Medical University

Principal Investigator

MACHIDA Takeshi  福島県立医科大学, 医学部・免疫学講座, 助教 (80583632)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsアレルギー・免疫関連疾患 / 全身性エリテマトーデス / MASP-1 / ループス腎炎 / MRL/lprマウス / 補体第二経路 / MRL/lpr
Research Abstract

Lupus-prone MRL/lpr mice deficient for MASP-1, a serine protease essential for activation of the alternative complement pathway, were generated and analyzed for development of autoimmune lupus-prone disease. Aged MASP-1 KO MRL/lpr mice showed reduced serum C3 consumption, reduced serum anti-dsDNA levels, and no/moderate glomerulonephritis compared to age-matched wild-type littermates, indicating that suppression of MASP-1 would be an effective therapeutic strategy forhuman lupus nephritis.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (18 results)

All 2013 2012 2011

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (12 results)

  • [Journal Article] Role of complement in a murine model of peanut-induced anaphylaxis.2013

    • Author(s)
      Kodama T1, Sekine H, Takahashi M, Iwaki D, Machida T, Kanno K, Ishida Y, Endo Y, Fujita T.
    • Journal Title

      Immunobiology

      Volume: 218 Issue: 6 Pages: 844-850

    • DOI

      10.1016/j.imbio.2012.10.003

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of both the lectin and classical pathways in peanut-induced complement activation and anaphylaxis2012

    • Author(s)
      Kodama T,Sekine H,Endo Y,Takahashi M,Iwaki D,Machida T,Kanno K,Ishida Y,Fujita T
    • Journal Title

      Immunobiology

      Volume: 218 Pages: 844-844

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chloroplastic NADPH-dependent thioredoxin reductase in Chlorella vulgaris alleviates environmental stresses in yeast with 2-Cys peroxiredoxin2012

    • Author(s)
      Machida T,Ishibashi A,Kirino A,Sato J,Kawasaki S,Niimura Y,Honjoh K,Miyamoto T
    • Journal Title

      PLoS ONE

      Volume: 7

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Circulating myeloid-derived suppressor cells are increased and correlate to immune supperssion,inflammation,and hypoproteinemia in patients with cancer2012

    • Author(s)
      Ohki S,Shibata M,Gonda K,Machida T,Shimura T,Nakamura I.Ohtake T,Koyama Y.Suzuki S.Ohto H.Takenoshita S
    • Journal Title

      Oncol Rep

      Volume: 28 Pages: 453-458

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chloroplastic NADPH- dependent thioredoxin reductase in Chlorella vulgaris alleviates environmental stresses in yeast with 2-Cys peroxiredoxin2012

    • Author(s)
      Takeshi Machida
    • Journal Title

      PLoS ONE

      Volume: 7 Issue: 9 Pages: e45988-e45988

    • DOI

      10.1371/journal.pone.0045988

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Circulating myeloid-derived suppressor cells are increased and correlate to immune suppression, inflammation and hypoproteinemia in patients with cancer.2012

    • Author(s)
      Ohki S, Shibata M, Gonda K, Machida T, Shimura T, Nakamura I, Ohtake T, Koyama Y, Suzuki S, Ohto H, Takenoshita S.
    • Journal Title

      Oncology Report

      Volume: 28 Issue: 2 Pages: 453-458

    • DOI

      10.3892/or.2012.1812

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] MRL/lprマウスで系統特異的に観察されるIFN-γ誘導性B細胞欠損2012

    • Author(s)
      町田豪、坂本夏美、山内直人、関根英治
    • Organizer
      研究連携セミナー2012
    • Place of Presentation
      福島県立医科大学
    • Year and Date
      2012-12-18
    • Related Report
      2012 Final Research Report
  • [Presentation] Lack of interferon regulatory factor-1 accelerates development of interstitial nephritis, renal vasculitis, and pulmonary granulomas with predominant Th2 polarity in MRL/lpr mice2012

    • Author(s)
      Machida T, Sakamoto N, Suzuki E, Zhang X, Reily CM, Gilkeson GS, Sekine H
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2012-12-07
    • Related Report
      2012 Final Research Report
  • [Presentation] IRF-1 deficient lupus-prone MRL/lpr mice show reduced glomerulonephritis but develop severe interstitial nephritis, renal vasculitis and pulmonary granulomas with propensity for Th2 polarity2012

    • Author(s)
      Sekine H, Machida T, Sakamoto N, SuzukiE, Zhang X, Reily CM, Gilkeson GS
    • Organizer
      IRF-1 deficient lupus-prone MRL/lpr mice show reduced glomerulonephritis but develop severe interstitial nephritis, renal vasculitis and pulmonary granulomas with propensity for Th2 polarity
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2012-11-10
    • Related Report
      2012 Final Research Report
  • [Presentation] Role of complement in a murine model of peanut-induced anaphylaxis2012

    • Author(s)
      Kodama T, Endo Y, Takahashi M, IwakiD, Machida T, Fujita T, Sekine H
    • Organizer
      XXIV International Complement Workshop
    • Place of Presentation
      Crete, Greece
    • Year and Date
      2012-10-12
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] IRF-1欠損SLEモデルマウスは自己反応性Th2細胞が関与する尿細管間質性腎炎、肺肉芽腫および胸腺肉芽腫を発症する2012

    • Author(s)
      坂本 夏美
    • Organizer
      研究連携セミナーポスター発表会2012
    • Place of Presentation
      福島県立医科大学, 福島
    • Related Report
      2012 Annual Research Report
  • [Presentation] MRL/lprマウスで系統特異的に観察されるIFN-γ誘導性B細胞欠損2012

    • Author(s)
      町田 豪
    • Organizer
      研究連携セミナーポスター発表会2012
    • Place of Presentation
      福島県立医科大学, 福島
    • Related Report
      2012 Annual Research Report
  • [Presentation] Lack of interferon regulatory factor-1 accelerates development of interstitial nephritis, renal vasculitis, and pulmonary granulomas with predominant Th2 polarity in MRL/lpr mice2012

    • Author(s)
      Takeshi Machida
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸国際会議場, 兵庫
    • Related Report
      2012 Annual Research Report
  • [Presentation] IRF-1 deficient lupus-prone MRL/lpr mice show reduced glomerulonephritis but develop severe interstitial nephritis, renal vasculitis and pulmonary granulomas with propensity for Th2 polarity2012

    • Author(s)
      Hideharu Sekine
    • Organizer
      2012-Annual Scientific Meeting of the American College of Rheumatology
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] IRF-4 deficient lupus-prone MRL/lprmice develop granulomatous lesions in multiple organs with strong propensity for Th1 polarity2011

    • Author(s)
      Machida T, Honma K, Matsuyama T, YuiK, Ruiz P, Fujita T, Gilkeson GS, Sekine H
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ
    • Year and Date
      2011-11-27
    • Related Report
      2012 Final Research Report
  • [Presentation] Interferon regulatory factor-4 deficient lupus-prone MRL/lpr mice show strong propensity for Th1 polarity and develop granulomatous lesions in multiple organs2011

    • Author(s)
      Sekine H, Machida T, Suzuki E, KinserTTH, Avila EM, Ruiz P, Reilly CM, Gilkeson GS
    • Organizer
      2011-Annual Scientific Meeting of the American College of Rheumatology
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2011-11-06
    • Related Report
      2012 Final Research Report
  • [Presentation] IRF-4 deficient lupus-prone MRL/lpr mice develop granulomatous lesions in multiple organs with strong propensity for Th1 polarity.2011

    • Author(s)
      町田豪
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Related Report
      2011 Research-status Report
  • [Presentation] Interferon regulatory factor -4 deficient lupus-prone MRL/lpr mice show strong propensity for Th1 polarity and develop granulomatous lesions in multiple organs.2011

    • Author(s)
      関根英治
    • Organizer
      2011-Annual Scientific Meeting of the American College of Rheumatology
    • Place of Presentation
      シカゴ(米国)
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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