Function analysis of MASP-1 as a therapeutic target for lupus-pronenephritis in MRL/lpr mice
Project/Area Number |
23790542
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Immunology
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Research Institution | Fukushima Medical University |
Principal Investigator |
MACHIDA Takeshi 福島県立医科大学, 医学部・免疫学講座, 助教 (80583632)
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | アレルギー・免疫関連疾患 / 全身性エリテマトーデス / MASP-1 / ループス腎炎 / MRL/lprマウス / 補体第二経路 / MRL/lpr |
Research Abstract |
Lupus-prone MRL/lpr mice deficient for MASP-1, a serine protease essential for activation of the alternative complement pathway, were generated and analyzed for development of autoimmune lupus-prone disease. Aged MASP-1 KO MRL/lpr mice showed reduced serum C3 consumption, reduced serum anti-dsDNA levels, and no/moderate glomerulonephritis compared to age-matched wild-type littermates, indicating that suppression of MASP-1 would be an effective therapeutic strategy forhuman lupus nephritis.
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Report
(3 results)
Research Products
(18 results)
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[Journal Article] Circulating myeloid-derived suppressor cells are increased and correlate to immune suppression, inflammation and hypoproteinemia in patients with cancer.2012
Author(s)
Ohki S, Shibata M, Gonda K, Machida T, Shimura T, Nakamura I, Ohtake T, Koyama Y, Suzuki S, Ohto H, Takenoshita S.
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Journal Title
Oncology Report
Volume: 28
Issue: 2
Pages: 453-458
DOI
Related Report
Peer Reviewed
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