| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
|---|
| Research Abstract |
In this study, we analyzed the mechanisms regulating histone modifications in the function and differentiation in CD8 T cells. We compared histone modifications and gene expressions by the genome-wide analyses in activated CD8 T cells. Both H3K4me3 and H3K9ac were positively correlated with gene expressions. The change in histone modifications in effector molecules after stimulation were associated with the effector function in CD8 T cells. Some histone methyltransferases and histone demethylases were upregluated and others were downregulated inCD8 T cells after stimulation. They were suggested to be associated with the change inhistone methylation in activated CD8 T cells. Together, the dynamic changes in histone methylation were supposed to regulate gene expressions in the function and differentiation in CD8 T cells.
|
