AhR regulates innate immune responses and Th17 cell differentiation

• Project/Area Number: 23790545
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Immunology
• Research Institution: Keio University
• Principal Investigator: KIMURA Akihiro 慶應義塾大学, 医学部, 助教 (20533318)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: ダイオキシン受容体 / listeria monocytogenes / 活性酸素 / マクロファージ / AIM / リステリア / リステリオリジン O

Research Abstract

AhR plays an important role in the host defense against Listeria monocytogenes(LM) infection. While AhR suppresses LM-induced pro-inflammatory cytokine production, AhR inhibits the cell death of macrophages infectedwith LM. In addition, AhR participates i

Research Products

• [Journal Article] Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis. (2013)
  • Author(s): Sekiya T, Kashiwagi I, Yoshida R, Fukaya T, et al.
  • Journal Title: Nat Immunol. Volume: 14 Issue: 3 Pages: 230-237
  • DOI: 10.1038/ni.2520
  • Peer Reviewed
• [Journal Article] IL-23-Independent Induction of IL-17 from γδT Cells and Innate Lymphoid Cells Promotes Experimental Intraocular Neovascularization (2013)
  • Author(s): Hasegawa E
  • Journal Title: J Immunol Volume: 190 Issue: 4 Pages: 1778-1787
  • DOI: 10.4049/jimmunol.1202495
  • Peer Reviewed
• [Journal Article] Forced expression of stabilized c-Fos in dendritic cells reduces cytokine production and immune responses in vivo. (2012)
  • Author(s): Yoshida R
  • Journal Title: Biochem Biophys Res Commun. Volume: 423 Issue: 2 Pages: 247-252
  • DOI: 10.1016/j.bbrc.2012.05.097
  • Peer Reviewed
• [Journal Article] Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain (2012)
  • Author(s): Shichita T
  • Journal Title: Nature Medicine Volume: 18 Issue: 6 Pages: 911-917
  • DOI: 10.1038/nm.2749
  • Peer Reviewed
• [Journal Article] Smad2 and Smad3 are redundantly essential for the suppression of iNOS synthesis in macrophages by regulating IRF3 and STAT1 pathways (2012)
  • Author(s): Sugiyama Yuki, 他
  • Journal Title: International Immunology Volume: 24 Issue: 4 Pages: 253-256
  • DOI: 10.1093/intimm/dxr126
  • Peer Reviewed
• [Journal Article] Low dose CP-690,550 (tofacitinib), a pan-JAK inhibitor, accelerates the onset of experimental autoimmune encephalomyelitis by potentiating Th17 differentiation. (2012)
  • Author(s): Yoshida H, Kimura A, Fukaya T, Sekiya T, Morita R, Shichita T, Inoue H, Yoshimura A
  • Journal Title: Biochem Biophys Res Commun Volume: 418 Pages: 234-240
  • Peer Reviewed
• [Journal Article] Low dose CP-690,550 (tofacitinib), a pan-JAK inhibitor, accelerates the onset of experimental autoimmune encephalomyelitis by potentiating Th17 differentiation (2012)
  • Author(s): Yoshida H, Kimura A, Fukaya T, Sekiya T, Morita R, Shichita T, Inoue H, Yoshimura A
  • Journal Title: Biochem Biophys Res Commun Volume: 418 Pages: 234-240
  • Peer Reviewed
• [Journal Article] SOCS1 is essential for regulatory T cell functions by preventing loss of Foxp3 expression as well as IFN-{gamma} and IL-17A production. (2011)
  • Author(s): Takahashi R, Nishimoto S, Muto G, Sekiya T, Tamiya T, Kimura A, Morita R, Asakawa M, Chinen T, Yoshimura A.
  • Journal Title: J Exp Med. Volume: 208 Issue: 10 Pages: 2055-2067
  • DOI: 10.1084/jem.20110428
  • Peer Reviewed
• [Journal Article] Aryl hydrocarbon receptor negatively regulates LPS-induced IL-6 production through suppression of histamine production in macrophages (2011)
  • Author(s): Masuda K, Kimura A, Hanieh H, Nguyen NT, Nakahama T, Chinen I, Otoyo Y, Murotani T, Yamatodani A, Kishimoto T.
  • Journal Title: Int Immunol Volume: 23 Issue: 10 Pages: 637-645
  • DOI: 10.1093/intimm/dxr072
  • Peer Reviewed
• [Journal Article] Aryl hydrocarbon receptor deficiency in T cells suppresses the development of collagen-induced arthritis (2011)
  • Author(s): Nakahama T, Kimura A, Nguyen NT, Chinen I, Hanieh H, Nohara K, Fujii-Kuriyama Y, Kishimoto T.
  • Journal Title: Proc Natl Acad Sci USA Volume: 108 Issue: 34 Pages: 14222-14227
  • DOI: 10.1073/pnas.1111786108
  • Peer Reviewed
• [Journal Article] Transcription Factor Smad-Independent T Helper 17 Cell Induction by Transforming-Growth Factor-ss Is Mediated by Suppression of Eomesodermin (2011)
  • Author(s): Kenji Ichiyama, 他
  • Journal Title: Immunity Volume: 34 Issue: 5 Pages: 741-754
  • DOI: 10.1016/j.immuni.2011.02.021
  • Peer Reviewed
• [Journal Article] The Influence of Excessive IL-6 Production In Vivo on the Development and Function of Foxp3+ Regulatory T Cells (2011)
  • Author(s): Fujimoto M, Nakano M, Terabe F, Kawahata H, Ohkawara T, Han Y, Ripley B, Serada S, Nishikawa T, Kimura A, Nomura S, Kishimoto T, Naka T
  • Journal Title: J Immunol Volume: 186 Pages: 32-40
  • Peer Reviewed
• [Journal Article] SOCS1 regulates type I/type II NKT cell balance by regulating IFNgamma signaling (2011)
  • Author(s): Hashimoto M, Hiwatashi K, Ichiyama K, Morita R, Sekiya T, Kimura A, Sugiyama Y, Sibata T, Kuroda K, Takahashi R, Yoshimura A
  • Journal Title: Int Immunol Volume: 23 Pages: 165-176
  • Peer Reviewed
• [Journal Article] Transcription Factor Smad-Independent T Helper 17 Cell Induction by Transforming-Growth Factor-β Is Mediated by Suppression of Eomesodermin. (2011)
  • Author(s): Ichiyama K, Sekiya T, Inoue N, Tamiya T, Kashiwagi I, Kimura A, Morita R, Muto G, Shichita T, Takahashi R, Yoshimura A
  • Journal Title: Immunity Volume: 34 Pages: 741-754
  • Peer Reviewed
• [Journal Article] Suppression of SOCS3 in macrophages prevents cancer metastasis by modifying macrophage phase and MCP2/CCL8 induction (2011)
  • Author(s): Hiwatashi K, Tamiya T, Hasegawa E, Fukaya T, Hashimoto M, Kakoi K, Kashiwagi I, Kimura A, Inoue N, Morita R, Yasukawa H, Yoshimura A
  • Journal Title: Cancer Lett Volume: 308 Pages: 172-180
  • Peer Reviewed
• [Journal Article] Histone 3 lysine 9 (H3K9) methyltransferase recruitment to the interleukin-2 (IL-2) promoter is a mechanism of suppression of IL-2 transcription by the transforming growth factor-β-Smad pathway (2011)
  • Author(s): Wakabayashi Y, Tamiya T, Takada I, Fukaya T, Sugiyama Y, Inoue N, Kimura A, Morita R, Kashiwagi I, Takimoto T, Nomura M, Yoshimura A
  • Journal Title: J Biol Chem Volume: 286 Pages: 35456-35465
  • Peer Reviewed
• [Presentation] Aryl hydrocarbon receptor is important for macrophage survival and protection against Listeria monocytogenesinfection (2012)
  • Author(s): 木村彰宏、吉村昭彦
  • Organizer: 第41回日本免疫学会総会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2012-12-06
• [Presentation] Aryl hydrocarbon receptor is important for macrophage survival and protection against Listeria monocytogenes infection (2012)
  • Author(s): 木村彰宏
  • Organizer: 第４１回日本免疫学会総会
  • Place of Presentation: 神戸国際会議場
• [Presentation] Aryl hydrocarbon receptor regulates innateimmune responses to Listeria monocytogenes. (2011)
  • Author(s): 木村彰宏、吉村昭彦
  • Organizer: 第40回日本免疫学会総会
  • Place of Presentation: 幕張メッセ
  • Year and Date: 2011-12-03
• [Presentation] Aryl hydrocarbon receptor regulates innate immune responses to Listeria monocytogenes (2011)
  • Author(s): Akihiro Kimura, Akihiko Yoshimura
  • Organizer: 9th Joint Meeting of the ICS/ISICR Firenze
  • Place of Presentation: Italy
  • Year and Date: 2011-10-10
• [Presentation] ダイオキシン-ダイオキシン受容体によるT細胞分化制御機構の解明 (2011)
  • Author(s): 木村彰宏、吉村昭彦
  • Organizer: 第6回日本ケミカルバイオロジー学会
  • Place of Presentation: 東京工業大学大岡山キャンパス
  • Year and Date: 2011-05-24
• [Presentation] Aryl hydrocarbon receptor regulates innate immune responses to Listeria monocytogenes (2011)
  • Author(s): Akihiro Kimura, Akihiko Yoshimura
  • Organizer: 9th Joint Meeting of the ICS/ISICR
  • Place of Presentation: Firenze, Italy
• [Book] Th17細胞の分化とIL-6の役割. 臨床免疫・アレルギー科、59 (2013)
  • Author(s): 木村彰宏
  • Publisher: 科学評論社
• [Book] Aryl hydrocarbon receptor/IDO産生樹状細胞によるレギュラトリーT細胞の誘導. 臨床免疫・アレルギー科、57 (2012)
  • Author(s): 木村彰宏
  • Publisher: 科学評論社
• [Remarks] 科学評論社
  • URL: http://new.immunoreg.jp/