AhR regulates innate immune responses and Th17 cell differentiation
Project/Area Number |
23790545
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Immunology
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Research Institution | Keio University |
Principal Investigator |
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | ダイオキシン受容体 / listeria monocytogenes / 活性酸素 / マクロファージ / AIM / リステリア / リステリオリジン O |
Research Abstract |
AhR plays an important role in the host defense against Listeria monocytogenes(LM) infection. While AhR suppresses LM-induced pro-inflammatory cytokine production, AhR inhibits the cell death of macrophages infectedwith LM. In addition, AhR participates i
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Report
(3 results)
Research Products
(25 results)
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[Journal Article] Low dose CP-690,550 (tofacitinib), a pan-JAK inhibitor, accelerates the onset of experimental autoimmune encephalomyelitis by potentiating Th17 differentiation.2012
Author(s)
Yoshida H, Kimura A, Fukaya T, Sekiya T, Morita R, Shichita T, Inoue H, Yoshimura A
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Journal Title
Biochem Biophys Res Commun
Volume: 418
Pages: 234-240
Related Report
Peer Reviewed
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[Journal Article] Low dose CP-690,550 (tofacitinib), a pan-JAK inhibitor, accelerates the onset of experimental autoimmune encephalomyelitis by potentiating Th17 differentiation2012
Author(s)
Yoshida H, Kimura A, Fukaya T, Sekiya T, Morita R, Shichita T, Inoue H, Yoshimura A
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Journal Title
Biochem Biophys Res Commun
Volume: 418
Pages: 234-240
Related Report
Peer Reviewed
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[Journal Article] The Influence of Excessive IL-6 Production In Vivo on the Development and Function of Foxp3+ Regulatory T Cells2011
Author(s)
Fujimoto M, Nakano M, Terabe F, Kawahata H, Ohkawara T, Han Y, Ripley B, Serada S, Nishikawa T, Kimura A, Nomura S, Kishimoto T, Naka T
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Journal Title
J Immunol
Volume: 186
Pages: 32-40
Related Report
Peer Reviewed
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[Journal Article] SOCS1 regulates type I/type II NKT cell balance by regulating IFNgamma signaling2011
Author(s)
Hashimoto M, Hiwatashi K, Ichiyama K, Morita R, Sekiya T, Kimura A, Sugiyama Y, Sibata T, Kuroda K, Takahashi R, Yoshimura A
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Journal Title
Int Immunol
Volume: 23
Pages: 165-176
Related Report
Peer Reviewed
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[Journal Article] Transcription Factor Smad-Independent T Helper 17 Cell Induction by Transforming-Growth Factor-β Is Mediated by Suppression of Eomesodermin.2011
Author(s)
Ichiyama K, Sekiya T, Inoue N, Tamiya T, Kashiwagi I, Kimura A, Morita R, Muto G, Shichita T, Takahashi R, Yoshimura A
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Journal Title
Immunity
Volume: 34
Pages: 741-754
Related Report
Peer Reviewed
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[Journal Article] Suppression of SOCS3 in macrophages prevents cancer metastasis by modifying macrophage phase and MCP2/CCL8 induction2011
Author(s)
Hiwatashi K, Tamiya T, Hasegawa E, Fukaya T, Hashimoto M, Kakoi K, Kashiwagi I, Kimura A, Inoue N, Morita R, Yasukawa H, Yoshimura A
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Journal Title
Cancer Lett
Volume: 308
Pages: 172-180
Related Report
Peer Reviewed
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[Journal Article] Histone 3 lysine 9 (H3K9) methyltransferase recruitment to the interleukin-2 (IL-2) promoter is a mechanism of suppression of IL-2 transcription by the transforming growth factor-β-Smad pathway2011
Author(s)
Wakabayashi Y, Tamiya T, Takada I, Fukaya T, Sugiyama Y, Inoue N, Kimura A, Morita R, Kashiwagi I, Takimoto T, Nomura M, Yoshimura A
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Journal Title
J Biol Chem
Volume: 286
Pages: 35456-35465
Related Report
Peer Reviewed
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