Analysis of the mechanisms of mTORC1-mediated IL-10 regulation in antigen presenting cells and the role of mTORC1 in colitis
| Project/Area Number |
23790546
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | Kansai Medical University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | mTORC1 / 樹状細胞 / IL-10 / 腸炎 / mTOR |
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| Research Abstract |
mTOR complex 1 (mTORC1) affects broad aspects of cellular functions such as growth and proliferation. We have previously demonstrated that mTORC1 positively regulates IL-10 production in dendritic cells (DC). Because it has been known that IL-10 is critical for onset of colitis, we assessed the role of mTORC1 in DC in colitis using DC-specific mTORC1 function-deleted (mTORC1^DC-/-) mice. In mTORC1^DC-/-mice, IL-10 expression in intestinal DC was decreased compared with control mice. In addition, mTORC1^DC-/- mice developed more severe experimental colitis. These results indicate that mTORC1 in DC influences the onset of colitis through IL-10-mediated regulation of innate immune response in vivo.
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Report
(3 results)
Research Products
(27 results)
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[Journal Article] mTORC1 in intestinal CD11c+CD11b+ dendritic cells regulates intestinal homeostasis by promoting IL-10 production.2012
Author(s)
Ohtani, M., Hoshii, T., Fujii, H., Koyasu, S., Hirao, A., Matsuda, S.
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Journal Title
The journal of immunology
Volume: in press
Related Report
Peer Reviewed
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[Presentation] mTOR complex 1 is critical for B cell development2012
Author(s)
Ohatni, M., Fujii, H., Sakai, K., Hoshii, T., Watanabe, T., Koyasu, S., Hirao, A., and Matsuda, S.
Organizer
第35回日本分子生物学会年会
Place of Presentation
福岡
Related Report
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[Presentation] Role of the mTORC1 signaling pathway in acquired immunity2012
Author(s)
Matsuda, S., Nagai, S., Hoshii, T., Koyasu, S., Hirao, A., and Ohtani, M.
Organizer
第35回日本分子生物学会年会(ワークショップ)
Place of Presentation
福岡
Related Report
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[Presentation] PI3K-Akt-mTORC1-S6K axis controls Th17 differentiation2012
Author(s)
Nagai, S., Kurebayashi, Y., Ikejiri, A., Ohtani, M., Baba, Y., Hoshii, T., Hirao, A., Matsuda, S., and Koyasu, S.
Organizer
第35回日本分子生物学会年会
Place of Presentation
福岡
Related Report
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