| Project/Area Number |
23790546
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
|
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| Research Institution | Kansai Medical University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
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| Keywords | mTORC1 / 樹状細胞 / IL-10 / 腸炎 / mTOR |
|---|
| Research Abstract |
mTOR complex 1 (mTORC1) affects broad aspects of cellular functions such as growth and proliferation. We have previously demonstrated that mTORC1 positively regulates IL-10 production in dendritic cells (DC). Because it has been known that IL-10 is critical for onset of colitis, we assessed the role of mTORC1 in DC in colitis using DC-specific mTORC1 function-deleted (mTORC1^DC-/-) mice. In mTORC1^DC-/-mice, IL-10 expression in intestinal DC was decreased compared with control mice. In addition, mTORC1^DC-/- mice developed more severe experimental colitis. These results indicate that mTORC1 in DC influences the onset of colitis through IL-10-mediated regulation of innate immune response in vivo.
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