The role for Rap1 signaling in the trafficking of germinal centerB cells

• Project/Area Number: 23790547
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Immunology
• Research Institution: Kansai Medical University
• Principal Investigator: UEDA Yoshihiro 関西医科大学, 医学部, 講師 (90533208)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 獲得免疫 / 胚中心 / 動態 / Rap1 / インテグリン / B細胞

Research Abstract

We found that secondary antibody responses were enhanced in Rap1-effector RAPL and Mst1-/- mice. The fact that LFA-1-/- B cells showed normal germinal center and memory B cell generation suggests LFA-independent regulation of B cell response in enhanced antibody production of RAPL and Mst1-/- mice.

Research Products

• [Journal Article] Mst1 regulates integrin-dependent thymocyte trafficking and antigen-recognition in the thymus. (2012)
  • Author(s): Ueda Y., Katagiri K., Tomiyama T., Yasuda K., Habiro K., Katakai T., Ikehara S., Matsumoto M, Kinashi T.
  • Journal Title: Nat. Commun. Volume: 3 Issue: 1 Pages: 1098-1098
  • DOI: 10.1038/ncomms2105
  • Peer Reviewed
• [Presentation] Crucial roles of LFA-1 regulation in thymocyte trafficking and antigen recognitionby Mst1 (2012)
  • Author(s): Ueda Yoshihiro
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸国際会議場
• [Presentation] Regulation of thymocyte trafficking and antigen recognition within thymic tissues through integrins and Rap1 effector Mst1 (2012)
  • Author(s): Yoshihiro Ueda, Koko Katagiri, Takashi Tomiyama, Kaneki Yasuda, Katsuyoshi Habiro, Tomoya Katakai, Susumu Ikehara and Tatsuo Kinashi
  • Organizer: 40th keystone symposia
  • Place of Presentation: Breckenridge, USA
• [Presentation] Crucial roles of LFA-1 regulation in thymocyte trafficking and antigen recognition by Mst1. (2012)
  • Author(s): UEDA Yoshihiro
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸・神戸国際会議場
• [Presentation] Mst1 regulates thymocyte trafficking and antigen recognition within thymictissues (2011)
  • Author(s): Ueda Yoshihiro, Katagiri Koko, Tomiyama Takashi, Yasuda Kaneki, Habiro Katsuyoshi, Katakai Tomoya, Ikehara Susumu, Kinashi Tatsuo
  • Organizer: 2011 The Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Chiba Japan
• [Presentation] Mst1 regulates thymocyte trafficking and antigen recognition within thymic tissues. (2011)
  • Author(s): Ueda Yoshihiro, Katagiri Koko, Tomiyama Takashi, Yasuda Kaneki, Habiro Katsuyoshi, Katakai Tomoya, Ikehara Susumu, Kinashi Tatsuo
  • Organizer: 2011 The Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Makuhari Messe Chiba Japan