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Cost-effectiveness of screening and treatment for sleep-disordered breathing

Research Project

Project/Area Number 23790567
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Medical sociology
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

TAKEGAMI Misa  独立行政法人国立循環器病研究センター, 研究開発基盤センター, 研究員 (50456860)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords医療経済学 / 費用対効果 / スクリーニング / 睡眠呼吸障害 / 睡眠時無呼吸症候群
Research Abstract

Sleep-disordered breathing (SDB), including obstructive sleep apnea increase the risk of cardiovascular disease. Moreover, because it may lead to mo¬tor vehicle and public transportation accidents. SDB is therefore consid¬ered a problem requiring attention from both clinical and public health perspectives. However, there is controversy regarding the value of treatment for SDB patients free of symptoms. Using a Markov model, we examined the cost-effectiveness of screening for SDB in Japan. SDB screening was found to be cost-effective in the simulations, if society is willing to pay between 20,000 pound sterling and 30,000 pound sterling per 1 Quality-adjusted life year (QALY), which is the threshold used by the National Institute for Health and Clinical Excellence (NICE).

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (16 results)

All 2014 2013 2012 Other

All Journal Article (14 results) (of which Peer Reviewed: 14 results) Presentation (2 results)

  • [Journal Article] Work Performance Assessed by a Newly Developed Japanese Version of the Work Limitation Questionnaire in a General Japanese Adult Population.2014

    • Author(s)
      Takegami M, Yamazaki S, Greenhill A, Chang H, Fukuhara S.
    • Journal Title

      Journal of Occupational Health

      Volume: in press

    • NAID

      130004447645

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Predicting Coronary Heart Disease Using Risk Factor Categories for a Japanese Urban Population, and Comparison with the ramingham Risk Score: The Suita Study.2014

    • Author(s)
      Nishimura K, Okamura T, Watanabe M, Nakai M, Takegami M, Higashiyama A, Kokubo Y, Okayama A, Miyamoto Y.
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: in press

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between sleep apnea, sleep duration and serum lipid profile in an urban male working population in Japan2013

    • Author(s)
      Toyama Y, Chin K, Chihara Y, Takegami M, Takahashi K, Sumi K, Nakamura T, Nakayama-Ashida Y, Minami I, Horita S, Oka Y, Wakamura T, Fukuhara S, Mishima M, Kadotani H
    • Journal Title

      Chest

      Volume: 143(3) Pages: 720-728

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Contribution of out-of-hospital factors to a reduction in cardiac arrest mortality due to witnessed ventricular fibrillation or tachycardia2013

    • Author(s)
      Nakamura F, Hayashino Y, Nishiuchi T, Kakudate N, Takegami M, Yamamoto Y, Yamazaki S, Fukuhara S
    • Journal Title

      Rsuscitation

      Volume: 84(6) Pages: 747-751

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association between sleep apnea, sleep duration and serum lipid profile in an urban male working population in Japan2013

    • Author(s)
      Toyama Y, Chin K, Kadotani H, et al
    • Journal Title

      Chest

      Volume: 143(3) Issue: 3 Pages: 720-8

    • DOI

      10.1378/chest.12-0338

    • Related Report
      2013 Annual Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Contribution of out-of-hospital factors to a reduction in cardiac arrest mortality due to witnessed ventricular fibrillation or tachycardia.2013

    • Author(s)
      Nakamura F, Hayashino Y, Nishiuchi T, Kakudate N, Takegami M, Yamamoto Y, Yamazaki S, Fukuhara S.
    • Journal Title

      Rsuscitation

      Volume: 84 Issue: 6 Pages: 747-751

    • DOI

      10.1016/j.resuscitation.2012.11.012

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationships of Decreased Lung Function with Metabolic Syndrome and Obstructive Sleep Apnea in Japanese Males2012

    • Author(s)
      Yoshimura C, Oga T, Chin K, Takegami M, Takahashi K, Sumi K, Nakamura T, Nakayama-Ashida Y, Minami I, Horita S, Oka Y, Wakamura T, Fukuhara S, Mishima M, Kadotani H
    • Journal Title

      Internal Medicin

      Volume: 51(17) Pages: 2291-2297

    • NAID

      130002062334

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differences in relationships among sleep apnoea, glucose level, sleep duration and sleepiness between persons with and without type 2 diabetes2012

    • Author(s)
      Harada Y, Oga T, Chin K, Takegami M, Takahashi K, Sumi K, Nakamura T, Nakayama-Ashida Y, Minami I, Horita S, Oka Y, Wakamura T, Fukuhara S, Mishima M, Kadotani H
    • Journal Title

      Journal of Sleep Research

      Volume: 21(4) Pages: 410-418

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Locomotor dysfunction and risk of cardiovascular disease, quality of life, medical cost : design of the Locomotive Syndrome and Health outcome in Aizu Cohort Study (LOHAS) and baseline characteristics of the study population2012

    • Author(s)
      Otani K, Takegami M, Fukumori N, Sekiguchi M, Onishi Y, Yamazaki S, Ono R, Otoshi K, Hayashino Y, Fukuhara S, Kikuchi S, Konno S, the LOHAS Research Group.
    • Journal Title

      Journal of Orthopaedic Science

      Volume: 17(3) Pages: 261-271

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationships of Decreased Lung Function with Metabolic Syndrome and Obstructive Sleep Apnea in Japanese Males.2012

    • Author(s)
      Yoshimura C, Oga T, Chin K, Takegami M, Takahashi K, Sumi K, Nakamura T, Nakayama-Ashida Y, Minami I, Horita S, Oka Y, Wakamura T, Fukuhara S, Mishima M, Kadotani H.
    • Journal Title

      Internal Medicine

      Volume: 51 Pages: 2291-2297

    • NAID

      130002062334

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Differences in relationships among sleep apnoea, glucose level, sleep duration and sleepiness between persons with and without type 2 diabetes2012

    • Author(s)
      Harada Y, Oga T, Chin K, Takegami M, Takahashi K, Sumi K, Nakamura T, Nakayama-Ashida Y, Minami I, Horita S, Oka Y, Wakamura T, Fukuhara S, Mishima M, Kadotani H
    • Journal Title

      Journal of Sleep Research

      Volume: 21 Issue: 4 Pages: 538-543

    • DOI

      10.1111/j.1365-2869.2012.00997.x

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Locomotor dysfunction and risk of cardiovascular disease, quality of life, medical cost: design of the Locomotive Syndrome and Health outcome in Aizu Cohort Study (LOHAS) and baseline characteristics of the study population.2012

    • Author(s)
      Otani K†, Takegami M†, Fukumori N, Sekiguchi M, Onishi Y, Yamazaki S, Ono R, Otoshi K, Hayashino Y, Fukuhara S, Kikuchi S, Konno S, the LOHAS Research Group. (†Equal contributors.)
    • Journal Title

      Journal of Orthopaedic Science

      Volume: 17 Issue: 3 Pages: 261-271

    • DOI

      10.1007/s00776-012-0200-5

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Work Performance Assessed by a Newly Developed Japanese Version of the Work Limitation Questionnaire in a General Japanese Adult Population

    • Author(s)
      Takegami M, Yamazaki S, Greenhill A, Chang H, Fukuhara S
    • Journal Title

      Journal of Occupational Healtn

      Volume: (in press)

    • NAID

      130004447645

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Predicting Coronary Heart Disease Using Risk Factor Categories for a Japanese Urban Population, and Comparison with the ramingham Risk Score : The Suita Study

    • Author(s)
      Nishimura K, Okamura T, Watanabe M, Nakai M, Takegami M, Higashiyama A, Kokubo Y, Okayama A, Miyamoto Y
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: (in press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] LDL / HDLコレステロール比は虚血性心疾患の発症を予測するか2014

    • Author(s)
      竹上未紗,渡邉至,小林貴,中井陸運,西村邦宏,小久保喜弘,宮本恵宏
    • Organizer
      第24回日本疫学会学術総会
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] LDL / HDLコレステロール比は虚血性心疾患の発症を予測するか2014

    • Author(s)
      竹上未紗、渡邉至、小林 貴、中井陸運、西村邦宏、小久保喜弘、宮本恵宏
    • Organizer
      日本疫学会
    • Place of Presentation
      仙台
    • Related Report
      2013 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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