Development of an animal model for the developmental disorders, especially autism spectrum disorder, by the postnatal stressand its pharmacotherapeutic intervention
Project/Area Number |
23790593
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Applied pharmacology
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Research Institution | Nagasaki International University |
Principal Investigator |
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | ストレス / 発達障害 / 自閉症 / モデル動物 / 社会的行動 / 幼児・児童虐待前臨床評価法 / 薬物治療 / 幼児・児童虐待 / 前臨床評価法 |
Research Abstract |
This study aimed at elucidating the pathophysiological mechanisms and establishing its preclinical drug evaluation for pharmacotherapy in the autism spectrum disorder, by investigating the validity as an animal model of the autism in rats experienced with postnatal stress. The findings in this study suggest that early postnatal stress might produce the social deficits in adolescent and postadolescent rats, indicating long-lasting changes of emotional susceptibilities possibly implicated in dysfunction of the GABAergic neuronal systems in the raphe nuclei. Furthermore, I established the new social interaction test in a single rat using a 3-compartment apparatus as new system to evaluate the rat social behaviors.
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Report
(3 results)
Research Products
(59 results)
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[Journal Article] Serotonin1A receptor- madiated synaptic responses in the ratmedial prefrontal cortex is altered byearly life stress2011
Author(s)
Kimura S, Togashi H, Matsumoto M, Shiozawa T, Ishida J, Kano S, Ohashi A,Ishikawa S, Yamaguchi T, Yoshioka M,Shimamura K.
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Journal Title
In vivo and in vitro electrophysiological studies., Jpn JNeuropsychopharmacol.
Volume: 31
Pages: 9-15
URL
Related Report
Peer Reviewed
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[Journal Article] Serotonin1A receptor-madiated synaptic responses in the rat medial prefrontal cortex is altered by early life stress: In vivo and in vitro electrophysiological studies.2011
Author(s)
Kimura S, Togashi H, Matsumoto M, Shiozawa T, Ishida J, Kano S, Ohashi A, Ishikawa S, Yamaguchi T, Yoshioka M, Shimamura K.
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Journal Title
Jpn J Neuropsychopharmacol.
Volume: 31
Pages: 9-15
Related Report
Peer Reviewed
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[Presentation] Anxiolytic effects of Yokukansan, a traditional Japanese medicine, via serotonin 5-HT1A receptors on anxiety-related behaviors in rats experienced with aversive stress.2012
Author(s)
Yamaguchi T., Tsujimatsu A, Kumamoto H, Izumi T, Ohmura Y, Yoshida T, Yamamoto T. and Yoshioka M
Organizer
The 29th Collegium Internationale Neuro-psychopharmacologicum (CINP) World Congress, Brussels, Belgium, Int. J. Neuropsychopharmacol., 15 (Suppl. I),95-96, (
Place of Presentation
Stockholm, Sweden
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