| Project/Area Number |
23790593
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied pharmacology
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| Research Institution | Nagasaki International University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ストレス / 発達障害 / 自閉症 / モデル動物 / 社会的行動 / 幼児・児童虐待前臨床評価法 / 薬物治療 / 幼児・児童虐待 / 前臨床評価法 |
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| Research Abstract |
This study aimed at elucidating the pathophysiological mechanisms and establishing its preclinical drug evaluation for pharmacotherapy in the autism spectrum disorder, by investigating the validity as an animal model of the autism in rats experienced with postnatal stress. The findings in this study suggest that early postnatal stress might produce the social deficits in adolescent and postadolescent rats, indicating long-lasting changes of emotional susceptibilities possibly implicated in dysfunction of the GABAergic neuronal systems in the raphe nuclei. Furthermore, I established the new social interaction test in a single rat using a 3-compartment apparatus as new system to evaluate the rat social behaviors.
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