Development of novel therapy for Parkinson's disease targeted toV-1 regulatory system of dopamine biosynthesis
Project/Area Number |
23790594
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Applied pharmacology
|
Research Institution | Tohoku University |
Principal Investigator |
KAWAHATA Ichiro 東北大学, 大学院・薬学研究科, 助教 (30579743)
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | V-1 / tyrosine hydroxylase / dopa decarboxylase / dopamine / cofilin / MAL/SRF / RhoA / actin / SRF / チロシン水酸化酵素 / ドパミン / 血清応答因子 / MAL/MKL / アクチン重合 / 初代培養系 |
Research Abstract |
The applicant discovered an unknown expression system of dopamine (DA) biosynthesizing enzymes for development of novel therapy of Parkinson's disease (PD). This regulatory system was found to be operated by V-1 through MAL/SRF-mediated pathway coupled with activation of RhoA and acceleration of actin polymerization in vitro and in vivo. The basis of V-1 gene therapy for PD was successfully established in this work.
|
Report
(3 results)
Research Products
(11 results)